4-Bromo-2-meth­oxy-6-(1-phenyl-1H-benzimidazol-2-yl)phenol

The title compound, C20H15BrN2O2, crystallized with three independent molecules in the asymmetric unit. Intramolecular O—H⋯N hydrogen bonds induce coplanarity of the substituted benzene ring and the benzimidazole ring, with mean deviations from the planes of 0.0931 (10), 0.0448 (10) and 0.0083 (11) Å in the three mol­ecules

The First Example of Tb-3-Containing Metallopolymer-Type Hybrid Materials with Efficient and High Color-Purity Green Luminescence

In the series of homo-leptic trinuclear complexes {[Ln(3)(L)(4)Cl-4(MeOH)(H2O)]center dot Cl} (Ln = La, 1; Ln = Eu, 2; Ln = Tb, 3 or Ln = Gd, 4) self-assembled from the allyl-modified benzimidazole-type ligand HL (4-allyl-2-(1H-benzo[d]imidazol-2-yl)-6-methoxyphenol) and LnCl(3)center dot 6H(2)O, a suitable energy level match endows efficient green luminescence (Phi(overall) = 72%) of Tb-3-arrayed complex 3. The copolymerization between each of these complex monomers 1-4 and C=C-containing MMA (methyl methacrylate) or NBE (norbornene) shows that degradative chain transfer of the terminal four flexible allyl groups within restrains their radical polymerization with MMA while it does not hinder their effective ring-opening metathesis polymerization (ROMP) with NBE. Thus, two kinds of PMMA-supported doping hybrid materials 1@PMMA, 2@PMMA, 3@PMMA and 4@PMMA and PNBE-supported metallopolymer-type hybrid materials Poly( NBE-1), Poly(NBE-2), Poly(NBE-3) and Poly(NBE-4) are obtained, respectively. Especially for both 3@PMMA and Poly(NBE-3) with high color-purity characteristic green emission of Tb3+ ions, improved physical properties including significantly enhanced luminescence (Phi(overall) = 76% or 83%) are observed, and covalent-bonding endows a higher-concentration self-quenching as compared to physical doping.National Natural Science Foundation 21373160, 91222201, 21173165Program for New Century Excellent Talents in University from the Ministry of Education of China NCET-10-0936Doctoral Program of Higher Education 20116101110003Science and Technology and Innovation Project of Shaanxi Province 2012KTCQ01-37Graduate Innovation and Creativity Fund (Visiting Learner) of Northwest University in P. R. ChinaChemistr

Research progress on rheumatoid arthritis-associated depression

Depression is an independent mood disorder and one of the most common comorbidities of rheumatoid arthritis (RA). Growing evidence suggests that there is two-way regulation between RA and depression, resulting in a vicious cycle of RA, depression, poor outcomes, and disease burden. The rising prevalence of RA-associated depression warrants a re-examination of the relationships between them. Here we provide an overview of the etiology and pathological mechanisms of RA-associated depression, and recent advances in treatment with biologics, which will facilitate the development of new and effective prevention and treatment strategies

Drug-coated balloon angioplasty with provisional stenting versus primary stenting for the treatment of de novo coronary artery lesions: REC-CAGEFREE I trial rationale and design

Background: Percutaneous coronary intervention (PCI) with primary stenting, which stands for stent implantation regardless of obtaining satisfactory results with balloon angioplasty, has superseded conventional plain old balloon angioplasty with provisional stenting. With drug-coated balloon (DCB), primary DCB angioplasty with provisional stenting has shown non-inferiority to primary stenting for de novo coronary small vessel disease. However, the long-term efficacy and safety of such a strategy to the primary stenting on clinical endpoints in de novo lesions without vessel diameter restrictions remain uncertain. Study design: The REC-CAGEFREE I is an investigator-initiated, multicenter, randomized, open-label trial aimed to enroll 2270 patients with acute or chronic coronary syndrome from 43 interventional cardiology centers in China to evaluate the non-inferiority of primary paclitaxel-coated balloons angioplasty to primary stenting for the treatment of de novo, non-complex lesions without vessel diameter restrictions. Patients who fulfill all the inclusion and exclusion criteria and have achieved a successful lesion pre-dilatation will be randomly assigned to the two arms in a 1:1 ratio. Protocol-guided DCB angioplasty and bailout stenting after unsatisfactory angioplasty are mandatory in the primary DCB angioplasty group. The second-generation sirolimus-eluting stent will be used as a bailout stent in the primary DCB angioplasty group and the treatment device in the primary stenting group. The primary endpoint is the incidence of Device-oriented Composite Endpoint (DoCE) within 24 months after randomization, including cardiac death, target vessel myocardial infarction, and clinically and physiologically indicated target lesion revascularization. Discussion: The ongoing REC-CAGEFREE I trial is the first randomized trial with a clinical endpoint to assess the efficacy and safety of primary DCB angioplasty for the treatment of de novo, non-complex lesions without vessel diameter restrictions. If non-inferiority is shown, PCI with primary DCB angioplasty could be an alternative treatment option to primary stenting. Trial registration: Registered on clinicaltrial.gov (NCT04561739)

Effects of small-scale turbulence at the air-water interface on microcystis surface scum formation

Cyanobacterial surface scum (here defined as visible Cyanobacteria colonies accumulating at the lake surface) is a harmful phenomenon that negatively affects water quality, human and animal health. Colony-forming Microcystis is one of the most important and ubiquitous genera that can suddenly accumulate at water surfaces. Turbulent water motion, e.g., generated by wind, can vertically disperse this scum layer, which later can re-establish by upward migration of Microcystis colonies. However, the role of wind-generated turbulence in scum formation and development is still poorly understood. Here we present results from a laboratory mesocosm study where we analysed the processes of scum formation and its response to wind-generated turbulence at low wind speed (&lt;= 3.6 m s(-1)). Microcystis colony size and flow velocity at the water surface and in the bulk water were measured using a microscope camera and particle tracking velocimetry. The surface scum formed by aggregation of colonies at the water surface, where they formed loose clusters of increasing size. The presence of large colony aggregations or of a surface film determined the stability of the scum layer. For the largest applied wind speed, most of the aggregations were broken down to sizes &lt;2 mm, which were dispersed to the bulk water. The surface scum recovered quickly from such disturbances after the wind speed decreased. We further observed reduced momentum transfer from wind to water with the growing scum layer. The presence of the scum increased the threshold wind speed for the onset of flow and reduced the flow velocities that were generated above that threshold. This effect was likely caused by the presence of a film of surface-active material at the water surface (surface microlayer), which is related to the presence of Microcystis. Both the small-scale turbulence and surface microlayer might play an important, yet largely unexplored role in Microcystis surface scum development in aquatic ecosystems. Improved understanding of the interplay of both processes will be instrumental for improving current mechanistic models for predicting surface bloom dynamics. (C) 2019 Elsevier Ltd. All rights reserved.</p

A Case of Congenital Syringocystadenoma Papilliferum

ABSTRACT: Syringocystadenoma papilliferum (SCAP) is a rare benign skin tumor that develops from the apocrine or eccrine glands. Here, we report the case of a 2-year-old girl who presented with an asymptomatic, slowly growing lesion on her scalp. On physical examination, a 2 cm × 1 cm red papillary plaque with a crusted surface was noted on her scalp. Histopathological examination revealed papillomatous expansion of the epidermis and cystic invaginations extending from the epidermis down to the deep dermis. The cystic structures were lined by papillae with two layers of columnar epithelium, which showed decapitation secretion. Based on the above clinicopathological findings, a diagnosis of congenital scalp SCAP was made

{2,2&amp;#8242;-[Cyclohexane-1,2-diylbis(nitrilomethanylylidene)]diphenolato}copper(II)

The title compound, [Cu(C20H20N2O2)], crystallizes with two independent molecules in the asymmetric unit. In each molecule, the CuII atom occupies the tetradentate N2O2 cavity of the salen-type Schiff base ligand, adopting a distorted square-planar geometry with r.m.s. deviations of the coordinating atoms of 0.0522&amp;#8197;(2) and 0.1128&amp;#8197;(4)&amp;#8197;&amp;#197;. No hydrogen bonds or &amp;#960;&amp;#8211;&amp;#960; stacking interaction are observed