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A generalisation of the method of regression calibration and comparison with Bayesian and frequentist model averaging methods

For many cancer sites low-dose risks are not known and must be extrapolated from those observed in groups exposed at much higher levels of dose. Measurement error can substantially alter the dose-response shape and hence the extrapolated risk. Recently, there has been considerable attention paid to methods of dealing with shared errors, which are particularly important in occupational and environmental settings. In this paper we test Bayesian model averaging (BMA) and frequentist model averaging (FMA) methods, the first of these similar to the so-called Bayesian two-dimensional Monte Carlo (2DMC) method, and both fairly recently proposed, against a very newly proposed modification of the regression calibration method, the extended regression calibration (ERC) method. The quasi-2DMC+BMA method performs well when a linear model is assumed, but poorly when a linear-quadratic model is assumed. FMA performs as well as quasi-2DMC+BMA when a linear model is assumed, and generally much better with a linear-quadratic model, although the coverage probability for the quadratic coefficient is uniformly too high. ERC yields coverage probabilities that are too low when shared and unshared Berkson errors are both large (50%), although otherwise it performs well, and coverage is generally better than the quasi-2DMC+BMA or FMA methods, particularly for the linear-quadratic model. The bias of predicted relative risk at a variety of doses is generally smallest for ERC, and largest for quasi-2DMC+BMA and FMA, with standard regression calibration and Monte Carlo maximum likelihood exhibiting bias in predicted relative risk generally somewhat intermediate between ERC and the other two methods. In general ERC performs best in the scenarios presented, and should be the method of choice in situations where there may be substantial shared error, or suspected curvature in the dose response.Comment: 5 Tables. Fortran code supplied externall

A Test of the Particle Paradigm in N-Body Simulations

We present results of tests of the evolution of small ``fluid elements'' in cosmological N--body simulations, to examine the validity of their treatment as particles. We find that even very small elements typically collapse along one axis while expanding along another, often to twice or more their initial comoving diameter. This represents a possible problem for high--resolution uses of such simulations.Comment: Uses aasms4.sty; accepted for publication in ApJ Letters. Files available also at ftp://kusmos.phsx.ukans.edu/preprints/ates

Propfan Test Assessment (PTA)

The objectives of the Propfan Test Assessment (PTA) Program were to validate in flight the structural integrity of large-scale propfan blades and to measure noise characteristics of the propfan in both near and far fields. All program objectives were met or exceeded, on schedule and under budget. A Gulfstream Aerospace Corporation GII aircraft was modified to provide a testbed for the 2.74m (9 ft) diameter Hamilton Standard SR-7 propfan which was driven by a 4475 kw (600 shp) turboshaft engine mounted on the left-hand wing of the aircraft. Flight research tests were performed for 20 combinations of speed and altitude within a flight envelope that extended to Mach numbers of 0.85 and altitudes of 12,192m (40,000 ft). Propfan blade stress, near-field noise on aircraft surfaces, and cabin noise were recorded. Primary variables were propfan power and tip speed, and the nacelle tilt angle. Extensive low altitude far-field noise tests were made to measure flyover and sideline noise and the lateral attenuation of noise. In coopertion with the FAA, tests were also made of flyover noise for the aircraft at 6100m (20,000 ft) and 10,668m (35,000 ft). A final series of tests were flown to evaluate an advanced cabin wall noise treatment that was produced under a separate program by NASA-Langley Research Center

Propfan Test Assessment (PTA): Flight test report

The Propfan Test Assessment (PTA) aircraft was flown to obtain glade stress and noise data for a 2.74m (9 ft.) diameter single rotation propfan. Tests were performed at Mach numbers to 0.85 and altitudes to 12,192m (40,000 ft.). The propfan was well-behaved structurally over the entire flight envelope, demonstrating that the blade design technology was completely adequate. Noise data were characterized by strong signals at blade passage frequency and up to 10 harmonics. Cabin noise was not so high as to preclude attainment of comfortable levels with suitable wall treatment. Community noise was not excessive

Dynamic Singularities in Cooperative Exclusion

We investigate cooperative exclusion, in which the particle velocity can be an increasing function of the density. Within a hydrodynamic theory, an initial density upsteps and downsteps can evolve into: (a) shock waves, (b) continuous compression or rarefaction waves, or (c) a mixture of shocks and continuous waves. These unusual phenomena arise because of an inflection point in the current versus density relation. This anomaly leads to a group velocity that can either be an increasing or a decreasing function of the density on either side of these wave singularities.Comment: 4 pages, 4 figures, 2 column revtex 4-1 format; version 2: substantially rewritten and put in IOP format, mail results unchanged; version 3: minor changes, final version for publication in JSTA

7-Li(p,n) Nuclear Data Library for Incident Proton Energies to 150 MeV

We describe evaluation methods that make use of experimental data, and nuclear model calculations, to develop an ENDF-formatted data library for the reaction p + Li7 for incident protons with energies up to 150 MeV. The important 7-Li(p,n_0) and 7-Li(p,n_1) reactions are evaluated from the experimental data, with their angular distributions represented using Lengendre polynomial expansions. The decay of the remaining reaction flux is estimated from GNASH nuclear model calculations. The evaluated ENDF-data are described in detail, and illustrated in numerous figures. We also illustrate the use of these data in a representative application by a radiation transport simulation with the code MCNPX.Comment: 11 pages, 8 figures, LaTeX, submitted to Proc. 2000 ANS/ENS International Meeting, Nuclear Applications of Accelerator Technology (AccApp00), November 12-16, Washington, DC, US