On the Mode in which External Applications Act on Internal Parts

From a dissertation by Joseph ListerLister joined the Royal Medical Society in 1854 and delivered this dissertation to the Society on 21st December 1855. In this dissertation he propounds the idea that there is "sympathy" between external and internal parts such that treatment of internal disease can be adequately treated by applications to the skin such as leeching, cautery and blistering. He illustrates conditions which may be treated by external applications, and attempts to describe the physiological basis of the treatment

Parent population of flat-spectrum radio-loud narrow-line Seyfert 1 galaxies

Flat-spectrum radio-loud Narrow-Line Seyfert 1 galaxies (NLS1s) are a recently discovered class of $\gamma$-ray emitting Active Galactic Nuclei (AGN), that exhibit some blazar-like properties which are explained with the presence of a relativistic jet viewed at small angles. When blazars are observed at larger angles they appear as radio-galaxies, and we expect to observe an analogue parent population for beamed NLS1s. However, the number of known NLS1s with the jet viewed at large angles is not enough. Therefore, we tried to understand the origin of this deficit. Current hypotheses about the nature of parent sources are steep-spectrum radio-loud NLS1s, radio-quiet NLS1s and disk-hosted radio-galaxies. To test these hypotheses we built three samples of candidate sources plus a control sample, and calculated their black hole mass and Eddington ratio using their optical spectra. We then performed a Kolmogorov-Smirnov statistical test to investigate the compatibility of our different samples with a beamed population. Our results indicate that, when the inclination angle increases, a beamed source appears as a steep-spectrum radio-loud NLS1, or possibly even as a disk-hosted radio-galaxy with low black hole mass and high Eddington ratio. Further investigations, involving larger complete samples and observations at radio frequency, are needed to understand the incidence of disk-hosted radio-galaxies in the parent population, and to assess whether radio-quiet NLS1s can play a role, as well.Comment: 12 pages, 6 figures, accepted for publication by Astronomy and Astrophysic

Muon-Spin Rotation Measurements of an Unusual Vortex-Glass Phase in the Layered Superconductor Bi2.15Sr1.85CaCu2O8+δ

Muon-spin rotation measurements, performed on the mixed state of the classic anisotropic superconductor Bi2.15Sr1.85CaCu2O8+δ, obtain quantities directly related to two- and three-body correlations of vortices in space. A novel phase diagram emerges from such local probe measurements of the bulk, revealing an unusual glassy state at intermediate fields which appears to freeze continuously from the equilibrium vortex liquid but differs both from the lattice and the conventional high-field vortex glass state in its structure.Publisher PDFPeer reviewe

An Exceptional Radio Flare in Markarian 421

In September 2012, the high-synchrotron-peaked (HSP) blazar Markarian 421 underwent a rapid wideband radio flare, reaching nearly twice the brightest level observed in the centimeter band in over three decades of monitoring. In response to this event we carried out a five epoch centimeter- to millimeter-band multifrequency Very Long Baseline Array (VLBA) campaign to investigate the aftermath of this emission event. Rapid radio variations are unprecedented in this object and are surprising in an HSP BL Lac object. In this flare, the 15 GHz flux density increased with an exponential doubling time of about 9 days, then faded to its prior level at a similar rate. This is comparable with the fastest large-amplitude centimeter-band radio variability observed in any blazar. Similar flux density increases were detected up to millimeter bands. This radio flare followed about two months after a similarly unprecedented GeV gamma-ray flare (reaching a daily E>100 MeV flux of (1.2 +/- 0.7)x10^(-6) ph cm^(-2) s^(-1)) reported by the Fermi Large Area Telescope (LAT) collaboration, with a simultaneous tentative TeV detection by ARGO-YBJ. A cross-correlation analysis of long-term 15 GHz and LAT gamma-ray light curves finds a statistically significant correlation with the radio lagging ~40 days behind, suggesting that the gamma-ray emission originates upstream of the radio emission. Preliminary results from our VLBA observations show brightening in the unresolved core region and no evidence for apparent superluminal motions or substantial flux variations downstream.Comment: 5 pages, 8 figures. Contributed talk at the meeting "The Innermost Regions of Relativistic Jets and Their Magnetic Fields", Granada, Spain. Updated to correct author list and reference

Splitting of Long-Period Comet C/2018 F4 (PANSTARRS)

Long-period comet C/2018 F4 (PANSTARRS) was observed to show duplicity of its inner region in 2020 September, suggestive of a splitting event. We here present analyses of our observations of the comet taken from the LOOK project and the University of Hawaii 2.2 m telescope after the discovery of the splitting. The two fragments Components A and B, estimated to be $\sim\!60$ m to 4 km in radius, remained highly similar to each other in terms of brightness, colour, and dust morphology throughout our observing campaign from 2020 September to 2021 December. Our fragmentation model yielded that the two components split at a relative speed of $3.00 \pm 0.18$ m s$^{-1}$ in 2020 late April, implying a specific energy change of $\left(5.3 \pm 2.8 \right) \times 10^3$ J kg$^{-1}$, and that Component B was subjected to a stronger nongravitational acceleration than Component A in both the radial and normal directions of the orbit. The obtained splitting time is broadly consistent with the result from the dust morphology analysis, which further suggested that the dominant dust grains were millimeter-sized and ejected at speed $\sim\!2$ m s$^{-1}$. We postulate that the pre-split nucleus of the comet consisted of two lobes resembling the one of 67P, or that the comet used to be a binary system like main-belt comet 288P. Regardless, we highlight the possibility of using observations of split comets as a feasible manner to study the bilobate shape or binarity fraction of cometary nuclei.Comment: Accepted to AJ for publicatio

The role of the purinergic P2X(7 )receptor in inflammation

The inflammatory process, orchestrated against a variety of injurious stimuli, is composed of three inter-related phases; initiation, propagation and resolution. Understanding the interplay between these three phases and harnessing the beneficial properties of inflammation whilst preventing its damaging effects, will undoubtedly lead to the advent of much needed therapies, particularly in chronic disease states. The P2X(7 )receptor (P2X(7)R) is increasingly recognised as an important cell surface regulator of several key inflammatory molecules including IL-1β, IL-18, TNF-α and IL-6. Moreover, as P2X(7)R-dependent cytokine production is driven by activating the inflammasome, antagonists of this receptor are likely to have therapeutic potential as novel anti-inflammatory therapies. The function of the P2X(7)R in inflammation, immunity and its potential role in disease will be reviewed and discussed

The role of the purinergic P2X(7 )receptor in inflammation

The inflammatory process, orchestrated against a variety of injurious stimuli, is composed of three inter-related phases; initiation, propagation and resolution. Understanding the interplay between these three phases and harnessing the beneficial properties of inflammation whilst preventing its damaging effects, will undoubtedly lead to the advent of much needed therapies, particularly in chronic disease states. The P2X(7 )receptor (P2X(7)R) is increasingly recognised as an important cell surface regulator of several key inflammatory molecules including IL-1β, IL-18, TNF-α and IL-6. Moreover, as P2X(7)R-dependent cytokine production is driven by activating the inflammasome, antagonists of this receptor are likely to have therapeutic potential as novel anti-inflammatory therapies. The function of the P2X(7)R in inflammation, immunity and its potential role in disease will be reviewed and discussed

Intrinsic brightness temperatures of blazar jets at 15 GHz

We have developed a new Bayesian Markov Chain Monte Carlo method to deconvolve light curves of blazars into individual flares, including proper estimation of the fit errors. We use the method to fit 15GHz light curves obtained within the OVRO 40-m blazar monitoring program where a large number of AGN have been monitored since 2008 in support of the Fermi Gamma-Ray Space Telescope mission. The time scales obtained from the fitted models are used to calculate the variability brightness temperature of the sources. Additionally, we have calculated brightness temperatures of a sample of these objects using Very Long Baseline Array data from the MOJAVE survey. Combining these two data sets enables us to study the intrinsic brightness temperature distribution in these blazars at 15 GHz. Our preliminary results indicate that the mean intrinsic brightness temperature in a sample of 14 sources is near the equipartition brightness temperature of ~ 10^(11)K

Spatial and Functional Relationships Among Pol V-Associated Loci, Pol IV-Dependent siRNAs, and Cytosine Methylation in the \u3cem\u3eArabidopsis\u3c/em\u3e Epigenome

Multisubunit RNA polymerases IV and V (Pols IV and V) mediate RNA-directed DNA methylation and transcriptional silencing of retrotransposons and heterochromatic repeats in plants. We identified genomic sites of Pol V occupancy in parallel with siRNA deep sequencing and methylcytosine mapping, comparing wild-type plants with mutants defective for Pol IV, Pol V, or both Pols IV and V. Approximately 60% of Pol V-associated regions encompass regions of 24-nucleotide (nt) siRNA complementarity and cytosine methylation, consistent with cytosine methylation being guided by base-pairing of Pol IV-dependent siRNAs with Pol V transcripts. However, 27% of Pol V peaks do not overlap sites of 24-nt siRNA biogenesis or cytosine methylation, indicating that Pol V alone does not specify sites of cytosine methylation. Surprisingly, the number of methylated CHH motifs, a hallmark of RNA-directed de novo methylation, is similar in wild-type plants and Pol IV or Pol V mutants. In the mutants, methylation is lost at 50%–60% of the CHH sites that are methylated in the wild type but is gained at new CHH positions, primarily in pericentromeric regions. These results indicate that Pol IV and Pol V are not required for cytosine methyltransferase activity but shape the epigenome by guiding CHH methylation to specific genomic sites