Additional file 1: Figure S1. of vIL-10-overexpressing human MSCs modulate naĂŻve and activated T lymphocytes following induction of collagenase-induced osteoarthritis

Timeline illustrating the induction of OA in mice followed by injection of five different treatment conditions at day 7. Six weeks after treatment animals were euthanised and the joints harvested for histological scoring. Lymph nodes and blood were taken for flow cytometric and multiplex ELISA analyses respectively. (PDF 9 kb

Additional file 2: Figure S2. of vIL-10-overexpressing human MSCs modulate naĂŻve and activated T lymphocytes following induction of collagenase-induced osteoarthritis

Representative safranin O-stained sections of the median scoring knee from each condition as well as an untreated contralateral knee for comparison: A Vehicle, B Ad-IL10 only, C MSCs only, D AdNull MSCs, E Ad-IL10 MSCs and F untreated contralateral knee. Erosion of the cartilage, osteophyte formation and synovial hyperplasia is visible in several of the images. Each image illustrates the medial compartment. FC femoral condyle, TC tibial condyle, S synovium, Op osteophyte. Scale bar =250 Îźm. (PDF 197 kb