Explore Physics Beyond the Standard Model with GLAST

We give an overview of the possibility of GLAST to explore theories beyond the Standard Model of particle physics. Among the wide taxonomy we will focus in particular on low scale supersymmetry and theories with extra space-time dimensions. These theories give a suitable dark matter candidate whose interactions and composition can be studied using a gamma ray probe. We show the possibility of GLAST to disentangle such exotic signals from a standard production background.Comment: 4 pages, 3 figure

Supersymmetry Breaking in a Minimal Anomalous Extension of the MSSM

We study a supersymmetry breaking mechanism in the context of a minimal anomalous extension of the MSSM. The anomaly cancellation mechanism is achieved through suitable counterterms in the effective action, i.e. Green-Schwarz terms. We assume that the standard MSSM superpotential is perturbatively realized, i.e. all terms allowed by gauge symmetries, except for the $\mu$-term which has a non-perturbative origin. The presence of this term is expected in many intersecting D-brane models which can be considered as the ultraviolet completion of our model. We show how soft supersymmetry breaking terms arise in this framework and we study the effect of some phenomenological constraints on this scenario.Comment: 31 pages, 13 figures, pdflatex, revised final versio

Dynamical Supersymmetry Breaking in Intersecting Brane Models

In this paper we study dynamical supersymmetry breaking in absence of gravity with the matter content of the minimal supersymmetric standard model. The hidden sector of the theory is a strongly coupled gauge theory, realized in terms of microscopic variables which condensate to form mesons. The supersymmetry breaking scalar potential combines F, D terms with instanton generated interactions in the Higgs-mesons sector. We show that for a large region in parameter space the vacuum breaks in addition to supersymmetry also electroweak gauge symmetry. We furthermore present local D-brane configurations that realize these supersymmetry breaking patterns.Comment: 30 pages, 4 figures, pdflate

Ultrasonic dynamic mechanical analysis (UDMA) for polymer characterization

Ultrasonic wave propagation has been used for the high frequency dynamic mechanical analysis of polymers with the aim to monitor the changes of viscoelastic properties in polymers associated with glass transition, crystallization, physical or chemical gelation, crosslinking, and curing reaction

5-Fluorouracil degradation rate as a predictive biomarker of toxicity in breast cancer patients treated with capecitabine

Capecitabine is an oral prodrug of 5-fluorouracil with a relevant role in the treatment of breast cancer. Severe and unexpected toxicities related to capecitabine are not rare, and the identification of biomarkers is challenging. We evaluate the relationship between dihydropyrimidine dehydrogenase, thymidylate synthase enhancer region and methylenetetrahydrofolate reductase polymorphisms, 5-fluorouracil degradation rate and the onset of G3–4 toxicities in breast cancer patients. Genetic polymorphisms and the 5-fluorouracil degradation rate of breast cancer patients treated with capecitabine were retrospectively studied. Genetic markers and the 5-fluorouracil degradation rate were correlated with the reported toxicities. Thirty-seven patients with a median age of 58 years old treated with capecitabine for stages II–IV breast cancer were included in this study. Overall, 34 (91.9%) patients suffered from at least an episode of any grade toxicity while nine patients had G3–4 toxicity. Homozygous methylenetetrahydrofolate reductase 677TT was found to be significantly related to haematological toxicity (OR = 6.5 [95% IC 1.1–37.5], P = 0.04). Three patients had a degradation rate less than 0.86 ng/mL/106 cells/min and three patients greater than 2.1 ng/mL/106 cells/min. At a univariate logistic regression analysis, an altered value of 5-fluorouracil degradation rate (values < 0.86 or >2.10 ng/mL/106 cells/min) increased the risk of G3–4 adverse events (OR = 10.40 [95% IC: 1.48–7.99], P = 0.02). A multivariate logistic regression analysis, adjusted for age, comorbidity and CAPE-regimen, confirmed the role of 5-fluorouracil degradation rate as a predictor of G3–4 toxicity occurrence (OR = 10.9 [95% IC 1.2–96.2], P = 0.03). The pre-treatment evaluation of 5-fluorouracil degradation rate allows to identify breast cancer patients at high risk for severe 5-FU toxicity

Out-Of-Plane permeability evaluation of carbon fiber preforms by ultrasonic wave propagation

Out-of-plane permeability of reinforcement preforms is of crucial importance in the infusion of large and thick composite panels, but so far, there are no standard experimental methods for its determination. In this work, an experimental set-up for the measurement of unsaturated through thickness permeability based on the ultrasonic wave propagation in pulse echo mode is presented. A single ultrasonic transducer, working both as emitter and receiver of ultrasonic waves, was used to monitor the through thickness flow front during a vacuum assisted resin infusion experiment. The set-up was tested on three thick carbon fiber preforms, obtained by stacking thermal bonding of balanced or unidirectional plies either by automated fiber placement either by hand lay-up of unidirectional plies. The ultrasonic data were used to calculate unsaturated out-of-plane permeability using Darcy's law. The permeability results were compared with saturated out-of-plane permeability, determined by a traditional gravimetric method, and validated by some analytical models. The results demonstrated the feasibility and potential of the proposed set-up for permeability measurements thanks to its noninvasive character and the one-side access

An Overview of the Measurement of Permeability of Composite Reinforcements

Liquid composite molding (LCM) is a class of fast and cheap processes suitable for the fabrication of large parts with good geometrical and mechanical properties. One of the main steps in an LCM process is represented by the filling stage, during which a reinforcing fiber preform is impregnated with a low-viscosity resin. Darcy’s permeability is the key property for the filling stage, not usually available and depending on several factors. Permeability is also essential in computational modeling to reduce costly trial-and-error procedures during composite manufacturing. This review aims to present the most used and recent methods for permeability measurement. Several solutions, introduced to monitor resin flow within the preform and to calculate the in-plane and out-of-plane permeability, will be presented. Finally, the new trends toward reliable methods based mainly on non-invasive and possibly integrated sensors will be described