Determination of complex optical constants and photovoltaic device design of all-inorganic CsPbBr₃ perovskite thin films

All-inorganic perovskites exhibit interesting properties and unprecedented stability compared to organic-inorganic hybrid lead halide perovskites. This work focuses on depositing and characterizing cesium lead bromide (CsPbBr3) thin films and determining their complex optical constants, which is a key requirement for photovoltaic device design. CsPbBr3 thin films are synthesized via the solution method followed by a hot-embossing step to reduce surface roughness. Variable angle spectroscopic ellipsometry measurements are then conducted at three angles (45°, 55°, and 65°) to obtain the ellipsometric parameters psi (Ψ) and delta (Δ). For the present model, bulk planar CsPbBr3 layer is described by a one-dimensional graded index model combined with the mixture of one Tauc-Lorentz oscillator and two Gaussian oscillators, while an effective medium approximation with 50% air void is adopted to describe surface roughness layer. The experimental complex optical constants are finally determined in the wavelength range of 300 to 1100 nm. Furthermore, as a design example demonstration, the simulations of single-junction CsPbBr3 solar cells are conducted via the finite-difference time-domain method to investigate the properties of light absorption and photocurrent density

Identification and Characterization of Key Chemical Constituents in Processed Gastrodia elata Using UHPLC-MS/MS and Chemometric Methods

© The Author(s) 2019. Background. Obesity is a major medical issue nationally, with rates continually increasing. In obese patients, minimal data exist for appropriate dosing of acyclovir to decrease the rates of nephrotoxicity. The purpose of this study was to determine the prevalence of and risk factors associated with acyclovir-induced nephrotoxicity. Methods. A retrospective case-control of patients who received intravenous acyclovir for \u3e48 hours at University of Mississippi Medical Center over a 4-year period were evaluated to elucidate the prevalence of acyclovir-induced nephrotoxicity. Additionally, risk factors for the development of nephrotoxicity, including the effect of obesity and dosing strategy, were assessed. Results. One hundred fifteen patients were included in the study. A total of 24 (21%) patients developed nephrotoxicity after acyclovir exposure and were in the Risk (9.6%), Injury (4.3%), and Failure (7%) categories, defined by the RIFLE criteria. Neither acyclovir dosage, fluid status, nor baseline characteristics, other than obesity, varied between those who developed nephrotoxicity vs those who did not. Independent predictors of nephrotoxicity were obesity (odds ratio [OR], 3.2; 95% confidence interval [CI], 1.19-8.67) and receipt of vancomycin (OR, 4.73; 95% CI, 1.57-14.25). No differences in vancomycin dosing or concentrations were observed between the patients who developed nephrotoxicity and those who did not. Conclusions. In this study, nephrotoxicity occurred in 21% of patients receiving acyclovir. Concomitant vancomycin receipt and obesity led to higher rates of toxicity. Efforts should be made to target obese patients on acyclovir plus vancomycin and discontinue therapy in patients not warranting antiviral coverage to minimize chances of toxicity

Crif1 Promotes Osteoporosis in Mice after Radiation

Abstract Radiation induces rapid bone loss and enhances bone resorption and RANKL expression. RANKL provides the crucial signal to induce osteoclast differentiation and plays an important role in bone resorption. However, the mechanisms of radiation-induced osteoporosis are not fully understood. Here, we show that Crif1 expression increases in bone marrow cells after radiation. Conditional Crif1 deletion in bone marrow cells causes decreases in RANKL expression and the RANKL/OPG ratio, and relieves bone loss after radiation in mice. We further demonstrated in vitro that Crif1 promotes RANKL secretion via the cAMP/PKA pathway. Moreover, protein-protein docking screening identified five compounds as Crif1 inhibitors; these compounds dramatically suppressed RANKL secretion and CREB phosphorylation when cells were exposed to forskolin. This study enriches current knowledge of the pathogenesis of osteoporosis and provides insights into potential therapeutic strategies for osteoporosis treatment

Pre-eruption deformation caused by dike intrusion beneath Kizimen volcano, Kamchatka, Russia, observed by InSAR

Abstract Interferometric synthetic aperture radar (InSAR) images reveal a pre-eruption deformation signal at Kizimen volcano, Kamchatka, Russia, where an ongoing eruption began in mid-November, 2010. The previous eruption of this basaltic andesite-to-dacite stratovolcano occurred in 1927–1928. InSAR images from both ascending and descending orbital passes of Envisat and ALOS PALSAR satellites show as much as 6 cm of line-of-sight shortening from September 2008 to September 2010 in a broad area centered at Kizimen. About 20 cm of opening of a nearly vertical dike provides an adequate fit to the surface deformation pattern. The model dike is approximately 14 km long, 10 km high, centered 13 km beneath Kizimen, and strikes NE–SW. Time-series analysis of multi-temporal interferograms indicates that (1) intrusion started sometime between late 2008 and July 2009, (2) continued at a nearly constant rate, and (3) resulted in a volume expansion of 3.2 × 107 m3 by September 2010, i.e., about two months before the onset of the 2010 eruption. Earthquakes located above the tip of the dike accompanied the intrusion. Eventually, magma pressure in the dike exceeded the confining strength of the host rock, triggering the 2010 eruption. Our results provide insight into the intrusion process that preceded an explosive eruption at a Pacific Rim stratovolcano following nearly a century of quiescence, and therefore have implications for monitoring and hazards assessment at similar volcanoes elsewhere

The impact of local government investment on the carbon emissions reduction effect: An empirical analysis of panel data from 30 provinces and municipalities in China.

Among studies of the factors that influence carbon emissions and related regulations, economic aggregates, industrial structures, energy structures, population levels, and energy prices have been extensively explored, whereas studies from the perspective of fiscal leverage, particularly of local government investment (LGI), are rare. Of the limited number of studies on the effect of LGI on carbon emissions, most focus on its direct effect. Few studies consider regulatory effects, and there is a lack of emphasis on local areas. Using a cointegration test, a panel data model and clustering analysis based on Chinese data between 2000 and 2013, this study measures the direct role of LGI in carbon dioxide (CO2) emissions reduction. First, overall, within the sample time period, a 1% increase in LGI inhibits carbon emissions by 0.8906% and 0.5851% through its influence on the industrial structure and energy efficiency, respectively, with the industrial structure path playing a greater role than the efficiency path. Second, carbon emissions to some extent exhibit inertia. The previous year's carbon emissions impact the following year's carbon emissions by 0.5375%. Thus, if a reduction in carbon emissions in the previous year has a positive effect, then the carbon emissions reduction effect generated by LGI in the following year will be magnified. Third, LGI can effectively reduce carbon emissions, but there are significant regional differences in its impact. For example, in some provinces, such as Sichuan and Anhui, economic growth has not been decoupled from carbon emissions. Fourth, the carbon emissions reduction effect in the 30 provinces and municipalities sampled in this study can be classified into five categories-strong, relatively strong, medium, relatively weak and weak-based on the degree of local governments' regulation of carbon emissions. The carbon emissions reduction effect of LGI is significant in the western and central regions of China but not in the eastern and northeast regions. This study helps overcome the limitations of previous studies on the regulatory effects of LGI on carbon emissions, and the constructed model may more closely reflect actual economic conditions. Moreover, the current study can benefit countries similar to China that aim to objectively identify the impacts of their LGI on carbon emissions, and such countries can use it as a reference in the formulation of investment policies based on their economic and industrial characteristics

Spatial and Temporal Variabilities of PM2.5 Concentrations in China Using Functional Data Analysis

As air pollution characterized by fine particulate matter has become one of the most serious environmental issues in China, a critical understanding of the behavior of major pollutant is increasingly becoming very important for air pollution prevention and control. The main concern of this study is, within the framework of functional data analysis, to compare the fluctuation patterns of PM2.5 concentration between provinces from 1998 to 2016 in China, both spatially and temporally. By converting these discrete PM2.5 concentration values into a smoothing curve with a roughness penalty, the continuous process of PM2.5 concentration for each province was presented. The variance decomposition via functional principal component analysis indicates that the highest mean and largest variability of PM2.5 concentration occurred during the period from 2003 to 2012, during which national environmental protection policies were intensively issued. However, the beginning and end stages indicate equal variability, which was far less than that of the middle stage. Since the PM2.5 concentration curves showed different fluctuation patterns in each province, the adaptive clustering analysis combined with functional analysis of variance were adopted to explore the categories of PM2.5 concentration curves. The classification result shows that: (1) there existed eight patterns of PM2.5 concentration among 34 provinces, and the difference among different patterns was significant whether from a static perspective or multiple dynamic perspectives; (2) air pollution in China presents a characteristic of high-emission “club” agglomeration. Comparative analysis of PM2.5 profiles showed that the heavy pollution areas could rapidly adjust their emission levels according to the environmental protection policies, whereas low pollution areas characterized by the tourism industry would rationally support the opportunity of developing the economy at the expense of environment and resources. This study not only introduces an advanced technique to extract additional information implied in the functions of PM2.5 concentration, but also provides empirical suggestions for government policies directed to reduce or eliminate the haze pollution fundamentally

A CROSS-PLATFORM .NET CUSTOMCONTROL ARCHITECTURE FOR HUMANMACHINE INTERFACE RUNTIME APPLICATION

The Human Machine Interface (HMI) is where interaction between humans and machines occurs. It is widely used in industry such as automatic control field. Controls such as button, text box and so on are fundamental and commonly used in the HMI. Controls typically contain the User Interface (UI) rendering and the business logic. The UI is the graphic display for users, and business logic is logic unit used to handle events of controls in UI. A typical HMI platform usually provides standard controls for users, but users may also want to use .NET custom controls such as self-defined controls and thirdparty controls. The feature of supporting .NET custom controls is what the thesis isconcern on. Siemens is developing a new HMI platform in which the HMI runtime software has no prior knowledge of a .NET custom control until it is loaded during runtime. However, the business logic of the .NET custom controls will ideally reside in the HMI runtime software, where the full runtime functionalities are available. The key of this concept is to separate the UI rendering of a control and the business logic of a control. Hosting business logic in the runtime will allow sharing the stable and UI-independent business logic across multiple platforms. In this thesis, a research of existing solutions for the cross-platform custom control concept is carried out, and the concept of .NET custom controls, possible architecture of the cross-process communication model for the thesis topic are defined. The solution of a cross-platform .NET custom control architecture for Siemens HMI runtime software is proposed and the prototype of the solution is implemented under both the Microsoft Windows 32-bit (Win32) and the Microsoft Windows Embedded CE 6.0 (WinCE 6.0) operating system environment. The prototype fulfills the functionality well under both the Win32 and the WinCE 6.0 environment. Furthermore, the prototype efficiency is measured by testing time overhead for method calling crossing process boundaries in the prototype. At last, a conclusion is made and future work is discussed

Tert-butylhydroquinone alleviates early brain injury and cognitive dysfunction after experimental subarachnoid hemorrhage: role of Keap1/Nrf2/ARE pathway.

Tert-butylhydroquinone (tBHQ), an Nrf2 activator, has demonstrated neuroprotection against brain trauma and ischemic stroke in vivo. However, little work has been done with respect to its effect on early brain injury (EBI) after subarachnoid hemorrhage (SAH). At the same time, as an oral medication, it may have extensive clinical applications for the treatment of SAH-induced cognitive dysfunction. This study was undertaken to evaluate the influence of tBHQ on EBI, secondary deficits of learning and memory, and the Keap1/Nrf2/ARE pathway in a rat SAH model. SD rats were divided into four groups: (1) Control group (n=40); (2) SAH group (n=40); (3) SAH+vehicle group (n=40); and (4) SAH+tBHQ group (n=40). All SAH animals were subjected to injection of autologous blood into the prechiasmatic cistern once in 20 s. In SAH+tBHQ group, tBHQ was administered via oral gavage at a dose of 12.5 mg/kg at 2 h, 12 h, 24 h, and 36 h after SAH. In the first set of experiments, brain samples were extracted and evaluated 48 h after SAH. In the second set of experiments, changes in cognition and memory were investigated in a Morris water maze. Results shows that administration of tBHQ after SAH significantly ameliorated EBI-related problems, such as brain edema, blood-brain barrier (BBB) impairment, clinical behavior deficits, cortical apoptosis, and neurodegeneration. Learning deficits induced by SAH was markedly alleviated after tBHQ therapy. Treatment with tBHQ markedly up-regulated the expression of Keap1, Nrf2, HO-1, NQO1, and GSTα1 after SAH. In conclusion, the administration of tBHQ abated the development of EBI and cognitive dysfunction in this SAH model. Its action was probably mediated by activation of the Keap1/Nrf2/ARE pathway

Analysis of prognostic factors for survival in patients with primary spinal chordoma using the SEER Registry from 1973 to 2014

Abstract Background Spinal chordomas are rare primary osseous tumors that arise from the remnants of the notochord. They are commonly considered slow-growing, locally invasive neoplasms with little tendency to metastasize, but the high recurrent rate of spinal chordomas may seriously affect the survival rate and quality of life of patients. The aim of the study is to describe the epidemiological data and determine the prognostic factors for decreased survival in patients with primary spinal chordoma. Methods The Surveillance, Epidemiology, and End Results (SEER) Registry database, a US population-based cancer registry database, was used to identify all patients diagnosed with primary spinal chordoma from 1973 to 2014. We utilized Kaplan–Meier method and Cox proportional hazards regression analysis to evaluate the association between patients overall survival and relevant characteristics, including age, gender, race, disease stage, treatment methods, primary tumor site, marital status, and urban county background. Results In the data set between 1973 and 2014, a total of 808 patients were identified with primary spinal chordoma. The overall rate of distant metastatic cases in our cohort was only 7.7%. Spinal chordoma was more common occurred in men (62.6%) than women (37.3%). Majority of neoplasms were found in the White (87.9%), while the incidence of the Black is relatively infrequent (3.3%). Three hundred fifty-seven spinal chordomas (44.2%) were located in the vertebral column, while 451 patients’ tumor (55.8%) was located in the sacrum or pelvis. Age ≥ 60 years (HR = 2.72; 95%CI, 1.71 to 2.89), distant metastasis (HR = 2.16; 95%CI, 1.54 to 3.02), and non-surgical therapy (HR = 2.14; 95%CI, 1.72 to 2.69) were independent risk factors for survival reduction in analysis. Survival did not significantly differ as a factor of tumor site (vertebrae vs sacrum/pelvis) for primary spinal chordoma (HR = 0.93, P = 0.16). Race (P = 0.52), gender (P = 0.11), marital status (P = 0.94), and urban background (P = 0.72) were not main factors which affected overall survival rate. Conclusion There was no significant difference in overall survival rate between chordomas located in the sacrum and vertebral column. Spinal chordoma patients with an elderly age (age ≥ 60), performing non-surgical therapy, and distant metastasis were associated with worse overall survival. Performing surgery was an effective and reliable treatment method for patients with spinal chordoma, and public health efforts should pay more attention to the elderly patients with spinal chordoma prior to distant metastasis