Management of a Type I Hypersensitivity Reaction to IV Etoposide in a Woman with a Yolk Sac Tumor: A Case Report

Type I hypersensitivity reactions to intravenous administration of etoposide are extremely rare. Etoposide is an essential component of several chemotherapy regimens used in gynecologic oncology, and discontinuation of this drug during a course of treatment should only be due to severe patient intolerance. We report the successful use of intravenous etoposide phosphate as a substitute drug in a patient with a yolk sac tumor who manifested a Type I hypersensitivity to intravenous etoposide. The patient ultimately completed all 4 cycles of bleomycin, etoposide, cisplatin (BEP) using etoposide phosphate as a substitute drug

NASA's Human Lunar Landing Strategy

In response to the 2018 White House Space Policy Directive-1 to lead an innovative and sustainable lunar exploration, and to the Vice Presidents March 2019 direction to do so by 2024, NASA is working to establish humanity's presence on and around the Moon by: 1) sending payloads to its surface, 2) assembling the Gateway outpost in orbit, and 3) conducting the first human lunar landings since 1972. NASAs Artemis program is implementing a multi-faceted and coordinated agency-wide approach with a focus on the lunar South Pole. The Artemis missions will demonstrate new technologies, capabilities and business approaches needed for future exploration, including Mars. Assessing options to accelerate development of systems, NASA is utilizing public-private engagements to develop and demonstrate capabilities that meet the agencys human space exploration objectives while stimulating the commercial space industry. Utilizing efforts across mission directorates, the Artemis effort will benefit from programs such as the Science Mission Directorates Commercial Lunar Payloads Services program and the Space Technology Mission Directorates Tipping Point partnerships for Moon and Mars technologies. This paper will discuss the strategic landscape for NASA's exploration campaign, the agency's approach to accessing the lunar surface with an affordable human-rated landing system, current status and role of U.S. industry, and future plans

NASA's Human Lunar Landing Strategy

No abstract availabl