207 research outputs found

    Digestible lysine effects on gene expression by Japanese quails in the pre-laying phase

    Get PDF
    This study aimed to determine the effects of digestible lysine levels in the diets of Japanese quail (Coturnix coturnix japonica) on performance, blood parameters and the expression of insulin-like growth factor I, and growth hormone receptor (GHR), apolipoprotein A-I (APOA-I), acetyl-CoA-carboxylase (ACC), and fatty acid synthase (FAS) genes. A total of 288 seven-day-old female Japanese quails were randomly assigned to one of three diets that contained 0.8%, 1.10%, or 1.40% digestible lysine. The birds were slaughtered at 42 days old, and relative gene expression was evaluated in the liver by qRT-PCR using the 2-ΔCT method. Lysine supplementation had no effect on weight gain and feed conversion. Abdominal fat was lower in birds supplemented with 0.8% digestible lysine than those supplemented with 1.10% and 1.40%. Increased total cholesterol and triglycerides were elevated in quails that received supplementation of 1.10% digestible lysine compared with the other diets. High density lipoproteins were decreased in birds that received 0.8% digestible lysine. Quails fed with 1.40% digestible lysine had greater expression of GHR and APOA-I than quails fed diets with 0.8 and 1.10% (P <0.05). The greatest expressions of ACC and FAS were observed in the liver of quails fed with 0.8% digestible lysine. The current results suggest that lysine supplementation in the pre-laying phase allows birds to deposit muscle mass to reach the optimal conformation and body fatness that provides an energetic reserve for the productive phase by modulating the expression of genes related to growth and lipid metabolism. Keywords: Coturnix coturnix japonica, growth, growth hormone, lipid synthesis, lipid metabolis

    The validity and reliability of the Portuguese versions of three tools used to diagnose delirium in critically ill patients

    Get PDF
    OBJECTIVES: The objectives of this study are to compare the sensitivity and specificity of three diagnostic tools for delirium (the Intensive Care Delirium Screening Checklist, the Confusion Assessment Method for Intensive Care Units and the Confusion Assessment Method for Intensive Care Units Flowsheet) in a mixed population of critically ill patients, and to validate the Brazilian Portuguese Confusion Assessment Method for Intensive Care Units. METHODS: The study was conducted in four intensive care units in Brazil. Patients were screened for delirium by a psychiatrist or neurologist using the Diagnostic and Statistical Manual of Mental Disorders. Patients were subsequently screened by an intensivist using Portuguese translations of the three tools. RESULTS: One hundred and nineteen patients were evaluated and 38.6% were diagnosed with delirium by the reference rater. The Confusion Assessment Method for Intensive Care Units had a sensitivity of 72.5% and a specificity of 96.2%; the Confusion Assessment Method for Intensive Care Units Flowsheet had a sensitivity of 72.5% and a specificity of 96.2%; the Intensive Care Delirium Screening Checklist had a sensitivity of 96.0% and a specificity of 72.4%. There was strong agreement between the Confusion Assessment Method for Intensive Care Units and the Confusion Assessment Method for Intensive Care Units Flowsheet (kappa coefficient = 0.96) CONCLUSION: All three instruments are effective diagnostic tools in critically ill intensive care unit patients. In addition, the Brazilian Portuguese version of the Confusion Assessment Method for Intensive Care Units is a valid and reliable instrument for the assessment of delirium among critically ill patients

    The CO2NSTRUCT European project: Modelling the role of Circular Economy in construction value chains for a carbon-neutral Europe

    Get PDF
    Linear climate mitigation models look into aggregated economic sectors and model greenhouse gas (GHG) emissions disregarding downstream value chains, making particular sectors accountable for downstream (or upstream) GHG emissions. Hence, the present climate mitigation models inconsistently account for indirect GHG emissions; underrepresent upstream and downstream value chains; do not address Circular Economy (CE) practices; do not cover resource consumption, thus not considering materials' circularity. To provide curated policy support for decision-making for carbon neutrality and other Sustainable Development Goals (SDGs), models need to shift from linear to circular. To achieve this, a link between energy-climate mitigation modelling and cradle-to-cradle assessment CE analytical tools must be established. This is the core issue covered in the CO2NSTRUCT Horizon project (2022-2026). CO2NSTRUCT proposes a framework to supplement the well-established JRC-EU-TIMES model, using a highly comprehensive technological representation with CE measures. The framework will apply CE measures to the value chain of six carbon-intensive construction materials (i.e., cement, steel, brick, glass, wood, and insulation materials) and will provide new components to the JRC-EU-TIMES model, including citizen behaviour; societal impacts; rebound effects; supply and value chains. The results will be used for policy approaches integrating CE into climate change mitigation actions

    Statistical Properties of the Linear Sigma Model

    Get PDF
    The statistical equilibrium properties of the linear sigma model are studied, with a view towards characterizing the field configurations employed as initial conditions for numerical simulations of the formation of disoriented chiral condensates in high-energy nuclear collisions. The field is decomposed into its spatial average (the order parameter) and the fluctuations (the quasi- particles) and enclosed in a rectangular box with periodic boundary conditions. The quantized quasi-particle modes are described approximately by Klein-Gordon dispersion relations containing an effective mass that depends on both the temperature and the magnitude of the order parameter. The thermal fluctuations are instrumental in shaping the effective potential governing the order parameter, and the evolution of its statistical distribution with temperature is discussed, as is the behavior of the associated effective masses. As the system is cooled the field fluctuations subside, causing a smooth change from the high-temperature phase in which chiral symmetry is approximately restored towards the normal phase. Of practical interest is the fact that the equilibrium field configurations can be sampled in a simple manner, thus providing a convenient means for specifying the initial conditions in dynamical simulations of the non-equilibrium relaxation of the chiral field. The corresponding correlation function is briefly considered and used to calculate the spectral strength of radiated pions. Finally, by propagating samples of initial configurations by the exact equation of motion, it has been ascertained that the treatment is sufficiently accurate to be of practical utility.Comment: 42 pages total, incl 18 figs using pstricks ([email protected]

    Evidence of Color Coherence Effects in W+jets Events from ppbar Collisions at sqrt(s) = 1.8 TeV

    Full text link
    We report the results of a study of color coherence effects in ppbar collisions based on data collected by the D0 detector during the 1994-1995 run of the Fermilab Tevatron Collider, at a center of mass energy sqrt(s) = 1.8 TeV. Initial-to-final state color interference effects are studied by examining particle distribution patterns in events with a W boson and at least one jet. The data are compared to Monte Carlo simulations with different color coherence implementations and to an analytic modified-leading-logarithm perturbative calculation based on the local parton-hadron duality hypothesis.Comment: 13 pages, 6 figures. Submitted to Physics Letters

    The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity

    Get PDF
    Background: Although previous studies evaluated the association of maternal health parameters with neonatal adiposity, little is known regarding the complexity of the relationships among different maternal health parameters throughout pregnancy and its impact on neonatal adiposity. Objectives: To evaluate the direct and indirect associations between maternal insulin resistance during pregnancy, in women with obesity, and neonatal adiposity. In addition, associations between maternal fasting glucose, triglycerides (TG), non-esterified fatty acids (NEFA), and neonatal adiposity were also assessed. Methods: This is a longitudinal, secondary analysis of the DALI study, an international project conducted in nine European countries with pregnant women with obesity. Maternal insulin resistance (HOMA-IR), fasting glucose, TG, and NEFA were measured three times during pregnancy (<20, 24-28, and 35-37 weeks of gestation). Offspring neonatal adiposity was estimated by the sum of four skinfolds. Structural equation modelling was conducted to evaluate the direct and indirect relationships among the variables of interest. Results: Data on 657 mother-infant pairs (50.7% boys) were analysed. Neonatal boys exhibited lower m
    corecore