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Platinum-Catalyzed Double Acylation of 2‑(Aryloxy)pyridines via Direct C–H Activation
A unique, platinum-catalyzed,
direct C–H acylation of 2-(aryloxy)Âpyridines
with acyl chlorides is discovered. The reaction requires neither an
oxidant nor other additives. When both <i>ortho</i> positions
of the aryl group are accessible, the double acylation occurs readily
to produce the diacylated products. Aliphatic, aromatic, and α,β-unsaturated
acyl groups can all be introduced. The acylation reaction may proceed
through an analogous aromatic electrophilic substitution triggered
by the nucleophilic attack of the platinum at the acyl chloride