371 research outputs found
Response of Piping Tees to Propagating Detonations
This paper reports the results of experiments and finite element simulations on the structural response of piping systems to internal detonation loading. Specifically, the work described in this paper focuses on the forces that are produced at tee-junctions that lead to axial and bending structural responses of the piping system.
Detonation experiments were conducted in a 2-in. (50 mm) diameter schedule 40 piping system that was fabricated using 304 stainless steel and welded to ASME B31.3 standards. The 4.1 m (162-in.) long piping system included one tee and was supported using custom brackets and cantilever beams fastened to steel plates that were bolted to the laboratory walls. Nearly-ideal detonations were used in a 30/70 H2-N2O mixture at 1 atm initial pressure and 300 K. Pressure and hoop, axial, and support strains were measured using a high-speed (1 MHz) digital data acquisition system and calibrated signal conditioners.
It was concluded that detonations propagate through the run of a 90° tee with relatively little disturbance in either direction. The detonation load increases by approximately a factor of 2 when the detonation enters through the branch. The deflections of the cantilever beam supports and the hoop and axial pipe strains could be adequately predicted by finite element simulations. The support loads are adequately predicted as long as the supports are constrained to the piping.
This paper shows that with relatively simple models, quantitative predictions of tee forces can be made for the purposes of design or safety analysis of piping systems subject to internal detonations
Olig2-Regulated Lineage-Restricted Pathway Controls Replication Competence in Neural Stem Cells and Malignant Glioma
Recent studies have identified stem cells in brain cancer. However, their relationship to normal CNS progenitors, including dependence on common lineage-restricted pathways, is unclear. We observe expression of the CNS-restricted transcription factor, OLIG2, in human glioma stem and progenitor cells reminiscent of type C transit-amplifying cells in germinal zones of the adult brain. Olig2 function is required for proliferation of neural progenitors and for glioma formation in a genetically relevant murine model. Moreover, we show p21^(WAF1/CIP1), a tumor suppressor and inhibitor of stem cell proliferation, is directly repressed by OLIG2 in neural progenitors and gliomas. Our findings identify an Olig2-regulated lineage-restricted pathway critical for proliferation of normal and tumorigenic CNS stem cells
A New High Contrast Imaging Program at Palomar Observatory
We describe a new instrument that forms the core of a long-term high contrast
imaging program at the 200-inch Hale Telescope at Palomar Observatory. The
primary scientific thrust is to obtain images and low-resolution spectroscopy
of brown dwarfs and young Jovian mass exoplanets in the vicinity of stars
within 50 parsecs of the Sun. The instrument is a microlens-based integral
field spectrograph integrated with a diffraction limited, apodized-pupil Lyot
coronagraph, mounted behind the Palomar adaptive optics system. The
spectrograph obtains imaging in 23 channels across the J and H bands (1.06 -
1.78 microns). In addition to obtaining spectra, this wavelength resolution
allows suppression of the chromatically dependent speckle noise, which we
describe. We have recently installed a novel internal wave front calibration
system that will provide continuous updates to the AO system every 0.5 - 1.0
minutes by sensing the wave front within the coronagraph. The Palomar AO system
is undergoing an upgrade to a much higher-order AO system ("PALM-3000"): a
3388-actuator tweeter deformable mirror working together with the existing
241-actuator mirror. This system will allow correction with subapertures as
small as 8cm at the telescope pupil using natural guide stars. The coronagraph
alone has achieved an initial dynamic range in the H-band of 2 X 10^-4 at 1
arcsecond, without speckle noise suppression. We demonstrate that spectral
speckle suppression is providing a factor of 10-20 improvement over this
bringing our current contrast at an arcsecond to ~2 X 10^-5. This system is the
first of a new generation of apodized pupil coronagraphs combined with
high-order adaptive optics and integral field spectrographs (e.g. GPI, SPHERE,
HiCIAO), and we anticipate this instrument will make a lasting contribution to
high contrast imaging in the Northern Hemisphere for years.Comment: Accepted to PASP: 12 pages, 12 figure
Recommended from our members
Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas
Classifying adult gliomas remains largely a histologic diagnosis based on morphology; however astrocytic, oligodendroglial and mixed lineage tumors can display overlapping histologic features. We used multiplexed exome sequencing (OncoPanel) on 108 primary or recurrent adult gliomas, comprising 65 oligodendrogliomas, 28 astrocytomas and 15 mixed oligoastrocytomas to identify lesions that could enhance lineage classification. Mutations in TP53 (20/28, 71%) and ATRX (15/28, 54%) were enriched in astrocytic tumors compared to oligodendroglial tumors of which 4/65 (6%) had mutations in TP53 and 2/65 (3%) had ATRX mutations. We found that oligoastrocytomas harbored mutations in TP53 (80%, 12/15) and ATRX (60%, 9/15) at frequencies similar to pure astrocytic tumors, suggesting that oligoastrocytomas and astrocytomas may represent a single genetic or biological entity. p53 protein expression correlated with mutation status and showed significant increases in astrocytomas and oligoastrocytomas compared to oligodendrogliomas, a finding that also may facilitate accurate classification. Furthermore our OncoPanel analysis revealed that 15% of IDH1/2 mutant gliomas would not be detected by traditional IDH1 (p.R132H) antibody testing, supporting the use of genomic technologies in providing clinically relevant data. In all, our results demonstrate that multiplexed exome sequencing can support evaluation and classification of adult low-grade gliomas with a single clinical test
Electric Field Conjugation with the Project 1640 coronagraph
The Project 1640 instrument on the 200-inch Hale telescope at Palomar
Observatory is a coronagraphic instrument with an integral field spectrograph
at the back end, designed to find young, self-luminous planets around nearby
stars. To reach the necessary contrast for this, the PALM-3000 adaptive optics
system corrects for fast atmospheric speckles, while CAL, a phase-shifting
interferometer in a Mach-Zehnder configuration, measures the quasistatic
components of the complex electric field in the pupil plane following the
coronagraphic stop. Two additional sensors measure and control low-order modes.
These field measurements may then be combined with a system model and data
taken separately using a white-light source internal to the AO system to
correct for both phase and amplitude aberrations. Here, we discuss and
demonstrate the procedure to maintain a half-plane dark hole in the image plane
while the spectrograph is taking data, including initial on-sky performance.Comment: 9 pages, 7 figures, in Proceedings of SPIE, 8864-19 (2013
Spectral Typing of Late Type Stellar Companions to Young Stars from Low Dispersion Near-Infrared Integral Field Unit Data
We used the Project 1640 near-infrared coronagraph and integral field
spectrograph to observe 19 young solar type stars. Five of these stars are
known binary stars and we detected the late-type secondaries and were able to
measure their JH spectra with a resolution of R\sim30. The reduced, extracted,
and calibrated spectra were compared to template spectra from the IRTF spectral
library. With this comparison we test the accuracy and consistency of spectral
type determination with the low-resolution near-infrared spectra from P1640.
Additionally, we determine effective temperature and surface gravity of the
companions by fitting synthetic spectra calculated with the PHOENIX model
atmosphere code. We also present several new epochs of astrometry of each of
the systems. Together these data increase our knowledge and understanding of
the stellar make up of these systems. In addition to the astronomical results,
the analysis presented helps validate the Project 1640 data reduction and
spectral extraction processes and the utility of low-resolution, near-infrared
spectra for characterizing late-type companions in multiple systems.Comment: Accepted to Astronomical Journal, 25 pages, 8 figure
Rope trauma, sedation, disentanglement, and monitoring-tag associated lesions in a terminally entangled North Atlantic right whale (Eubalaena glacialis)
Author Posting. © Society for Marine Mammalogy, 2012. Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://wileyonlinelibrary.com/onlineopen#OnlineOpen_Terms. The definitive version was published in Marine Mammal Science 29 (2013): E98–E113, doi:10.1111/j.1748-7692.2012.00591.x.A chronically entangled North Atlantic right whale, with consequent emaciation was sedated, disentangled to the extent possible, administered antibiotics, and satellite tag tracked for six subsequent days. It was found dead 11 d after the tag ceased transmission. Chronic constrictive deep rope lacerations and emaciation were found to be the proximate cause of death, which may have ultimately involved shark predation. A broadhead cutter and a spring-loaded knife used for disentanglement were found to induce moderate wounds to the skin and blubber. The telemetry tag, with two barbed shafts partially penetrating the blubber was shed, leaving barbs embedded with localized histological reaction. One of four darts administered shed the barrel, but the needle was found postmortem in the whale with an 80º bend at the blubber-muscle interface. This bend occurred due to epaxial muscle movement relative to the overlying blubber, with resultant necrosis and cavitation of underlying muscle. This suggests that rigid, implanted devices that span the cetacean blubber muscle interface, where the muscle moves relative to the blubber, could have secondary health impacts. Thus we encourage efforts to develop new tag telemetry systems that do not penetrate the subdermal sheath, but still remain attached for many months.Funding from NOAA Cooperative Agreement NA09OAR4320129, PO
EA133F09SE4792, M. S. Worthington Foundation, North Pond Foundation, Sloan and
Hardwick Simmons, and Woods Hole Oceanographic Institution Marine Mammal
Center
HUMMR, a hypoxia- and HIF-1α–inducible protein, alters mitochondrial distribution and transport
Mitochondrial transport is critical for maintenance of normal neuronal function. Here, we identify a novel mitochondria protein, hypoxia up-regulated mitochondrial movement regulator (HUMMR), which is expressed in neurons and is markedly induced by hypoxia-inducible factor 1 α (HIF-1α). Interestingly, HUMMR interacts with Miro-1 and Miro-2, mitochondrial proteins that are critical for mediating mitochondrial transport. Interestingly, knockdown of HUMMR or HIF-1 function in neurons exposed to hypoxia markedly reduces mitochondrial content in axons. Because mitochondrial transport and distribution are inextricably linked, the impact of reduced HUMMR function on the direction of mitochondrial transport was also explored. Loss of HUMMR function in hypoxia diminished the percentage of motile mitochondria moving in the anterograde direction and enhanced the percentage moving in the retrograde direction. Thus, HUMMR, a novel mitochondrial protein induced by HIF-1 and hypoxia, biases mitochondria transport in the anterograde direction. These findings have broad implications for maintenance of neuronal viability and function during physiological and pathological states
- …