Proteomics in Pancreatic Cancer Research

Pancreatic cancer is a highly aggressive malignancy with a poor prognosis and deeply affects the life of people. Therefore, the earlier diagnosis and better treatments are urgently needed. In recent years, the proteomic technologies are well established and growing rapidly and have been widely applied in clinical applications, especially in pancreatic cancer research. In this paper, we attempt to discuss the development of current proteomic technologies and the application of proteomics to the field of pancreatic cancer research. This will explore the potential perspective in revealing pathogenesis, making the diagnosis earlier and treatment

Neural Wavelet-domain Diffusion for 3D Shape Generation

This paper presents a new approach for 3D shape generation, enabling direct generative modeling on a continuous implicit representation in wavelet domain. Specifically, we propose a compact wavelet representation with a pair of coarse and detail coefficient volumes to implicitly represent 3D shapes via truncated signed distance functions and multi-scale biorthogonal wavelets, and formulate a pair of neural networks: a generator based on the diffusion model to produce diverse shapes in the form of coarse coefficient volumes; and a detail predictor to further produce compatible detail coefficient volumes for enriching the generated shapes with fine structures and details. Both quantitative and qualitative experimental results manifest the superiority of our approach in generating diverse and high-quality shapes with complex topology and structures, clean surfaces, and fine details, exceeding the 3D generation capabilities of the state-of-the-art models

ISS++: Image as Stepping Stone for Text-Guided 3D Shape Generation

In this paper, we present a new text-guided 3D shape generation approach (ISS++) that uses images as a stepping stone to bridge the gap between text and shape modalities for generating 3D shapes without requiring paired text and 3D data. The core of our approach is a two-stage feature-space alignment strategy that leverages a pre-trained single-view reconstruction (SVR) model to map CLIP features to shapes: to begin with, map the CLIP image feature to the detail-rich 3D shape space of the SVR model, then map the CLIP text feature to the 3D shape space through encouraging the CLIP-consistency between rendered images and the input text. Besides, to extend beyond the generative capability of the SVR model, we design a text-guided 3D shape stylization module that can enhance the output shapes with novel structures and textures. Further, we exploit pre-trained text-to-image diffusion models to enhance the generative diversity, fidelity, and stylization capability. Our approach is generic, flexible, and scalable, and it can be easily integrated with various SVR models to expand the generative space and improve the generative fidelity. Extensive experimental results demonstrate that our approach outperforms the state-of-the-art methods in terms of generative quality and consistency with the input text. Codes and models are released at https://github.com/liuzhengzhe/ISS-Image-as-Stepping-Stone-for-Text-Guided-3D-Shape-Generation.Comment: Under review of TPAM

ISS: Image as Stepping Stone for Text-Guided 3D Shape Generation

Text-guided 3D shape generation remains challenging due to the absence of large paired text-shape data, the substantial semantic gap between these two modalities, and the structural complexity of 3D shapes. This paper presents a new framework called Image as Stepping Stone (ISS) for the task by introducing 2D image as a stepping stone to connect the two modalities and to eliminate the need for paired text-shape data. Our key contribution is a two-stage feature-space-alignment approach that maps CLIP features to shapes by harnessing a pre-trained single-view reconstruction (SVR) model with multi-view supervisions: first map the CLIP image feature to the detail-rich shape space in the SVR model, then map the CLIP text feature to the shape space and optimize the mapping by encouraging CLIP consistency between the input text and the rendered images. Further, we formulate a text-guided shape stylization module to dress up the output shapes with novel textures. Beyond existing works on 3D shape generation from text, our new approach is general for creating shapes in a broad range of categories, without requiring paired text-shape data. Experimental results manifest that our approach outperforms the state-of-the-arts and our baselines in terms of fidelity and consistency with text. Further, our approach can stylize the generated shapes with both realistic and fantasy structures and textures

Improving Multi-turn Emotional Support Dialogue Generation with Lookahead Strategy Planning

Providing Emotional Support (ES) to soothe people in emotional distress is an essential capability in social interactions. Most existing researches on building ES conversation systems only considered single-turn interactions with users, which was over-simplified. In comparison, multi-turn ES conversation systems can provide ES more effectively, but face several new technical challenges, including: (1) how to adopt appropriate support strategies to achieve the long-term dialogue goal of comforting the user's emotion; (2) how to dynamically model the user's state. In this paper, we propose a novel system MultiESC to address these issues. For strategy planning, drawing inspiration from the A* search algorithm, we propose lookahead heuristics to estimate the future user feedback after using particular strategies, which helps to select strategies that can lead to the best long-term effects. For user state modeling, MultiESC focuses on capturing users' subtle emotional expressions and understanding their emotion causes. Extensive experiments show that MultiESC significantly outperforms competitive baselines in both dialogue generation and strategy planning. Our codes are available at https://github.com/lwgkzl/MultiESC.Comment: Accepted by the main conference of EMNLP 202