2 research outputs found
Enantioselective Formation of CF<sub>3</sub>‑Bearing All-Carbon Quaternary Stereocenters via C–H Functionalization of Methanol: Iridium Catalyzed Allene Hydrohydroxymethylation
Using an iridium
catalyst modified by PhanePhos, CF<sub>3</sub>-allenes react with
methanol to form branched products of hydrohydroxymethylation
as single regioisomers with excellent levels of enantiomeric enrichment.
This hydrogen autotransfer process enables catalytic enantioselective
formation of acyclic CF<sub>3</sub>-bearing all-carbon quaternary
stereocenters in the absence of stoichiometric metals or byproducts
Enantioselective Formation of CF<sub>3</sub>‑Bearing All-Carbon Quaternary Stereocenters via C–H Functionalization of Methanol: Iridium Catalyzed Allene Hydrohydroxymethylation
Using an iridium
catalyst modified by PhanePhos, CF<sub>3</sub>-allenes react with
methanol to form branched products of hydrohydroxymethylation
as single regioisomers with excellent levels of enantiomeric enrichment.
This hydrogen autotransfer process enables catalytic enantioselective
formation of acyclic CF<sub>3</sub>-bearing all-carbon quaternary
stereocenters in the absence of stoichiometric metals or byproducts