Spectrophotometric color measurements (L*, a*, b*, WI and YI) in control teeth and those heated at 100, 200, or 400°C for 60 minutes.

<p>Histograms represent means ± SEM (n = 10). ANOVA: **^/***<i>p</i><0.01/0.001 vs. control group, ^##/###<i>p</i><0.01/0.001 vs. 100°C, ^{$$ $}<i>p</i><0.001 vs. 200°C.</p

Correlation between spectrophotometric color parameters (<i>L</i>*, <i>a</i>*, <i>b</i>*, WI and YI) and DNA concentration in control teeth and teeth heated at 100, 200 or 400°C for 60 minutes.

<p>DNA concentration was represented on a logarithm scale (base 10).</p

Spectrophotometric color values and DNA concentrations at different temperatures.

<p>Spectrophotometric color values and DNA concentrations at different temperatures.</p

Morphologic and color changes in teeth after exposure at different temperatures (in°C).

<p>Longitudinal and transversal fissures are indicated by black arrows and longitudinal and transversal fractures by white arrows. An example of the separation between enamel and dentin is depicted in the last right photograph.</p

DNA concentration in control teeth and teeth heated at 100, 200, and 400°C for 60 minutes.

<p>Histograms represent means ± SEM (n = 10). ANOVA: ***<i>p</i><0.001 vs.100, 200 and 400°C, ^##<i>p</i><0.01 vs. 200 and 400°C, ^$<i>p</i><0.05 vs. 400°C.</p

Supplemental Material, DS1_IJT_10.1177_1091581818777998 - Development of a Phototoxicity Testing Strategy for Accurate Photosafety Evaluation of Pharmaceuticals Based on the Assessment of Possible Melanin-Binding Effects

<p>Supplemental Material, DS1_IJT_10.1177_1091581818777998 for Development of a Phototoxicity Testing Strategy for Accurate Photosafety Evaluation of Pharmaceuticals Based on the Assessment of Possible Melanin-Binding Effects by Jelle Reinen, Pieter van Sas, Ton van Huygevoort, Leticia Rubio, Kevin Scase, and Mira Wenker in International Journal of Toxicology</p