Chiral Rings, Vacua and Gaugino Condensation of Supersymmetric Gauge Theories

We find the complete chiral ring relations of the supersymmetric U(N) gauge theories with matter in adjoint representation. We demonstrate exact correspondence between the solutions of the chiral ring and the supersymmetric vacua of the gauge theory. The chiral ring determines the expectation values of chiral operators and the low energy gauge group. All the vacua have nonzero gaugino condensation. We study the chiral ring relations obeyed by the gaugino condensate. These relations are generalizations of the formula $S^N=\Lambda^{3N}$ of the pure ${\cal N} =1$ gauge theory.Comment: 38 page

Curacazgo Jalca : demografía y recursos de los Chachapoya prehispánicos

La investigación enfoca la presión demográfica prehispánica dentro de un medioambiente frágil y de extrema variedad antes y después de la presencia del estado Inca.Alemania. Financiado por el Servicio Alemán de Intercambio Académico (Deutscher Akademischer Austauschdienst - DAAD).Tesi

Inconsistent reporting of surrogate outcomes in randomised clinical trials: cohort study

Objective To assess if authors of randomised clinical trials convey the fact that they have used surrogate outcomes and discussed their validity

Planung, Konzeption und Umsetzung eines Web-Verzeichnisses für Foto- und Bildressourcen im World Wide Web

Gegenstand der hier vorgestellten Arbeit ist die Planung, Konzeption und Umsetzung eines Web-Verzeichnisses für Foto- und Bildressourcen im World Wide Web. Unter www.bildfilter.com wird dieses Verzeichnis erreicht und bietet derzeit (Stand 04.08.04) über 120 rezensierte Links zu Foto- und Bildressourcen, die auf Basis der CSSprogramierten Struktur ständig aktualisiert und künftig erweitert werden. Ferner wird in dieser Arbeit der Bildermarkt allgemein, sowie anhand von zwei kommerziellen und zwei nicht-kommerziellen Internetauftritten bekannter Bildanbieter besprochen

Oral intake of bucillamine, carvedilol, metformin, or phenformin does not protect against UVR-induced squamous cell carcinomas in hairless mice

Squamous cell carcinoma represents the second most common type of keratinocyte carcinoma with ultraviolet radiation (UVR) making up the primary risk factor. Oral photoprotection aims to reduce incidence rates through oral intake of photoprotective compounds. Recently, drug repurposing has gained traction as an interesting source of chemoprevention. Because of their reported photoprotective properties, we investigated the potential of bucillamine, carvedilol, metformin, and phenformin as photoprotective compounds following oral intake in UVR-exposed hairless mice. Tumour development was observed in all groups in response to UVR, with only the positive control (Nicotinamide) demonstrating a reduction in tumour incidence (23.8%). No change in tumour development was observed in the four repurposed drug groups compared to the UV control group, whereas nicotinamide significantly reduced carcinogenesis (P = 0.00012). Metformin treatment significantly reduced UVR-induced erythema (P = 0.012), bucillamine and phenformin increased dorsal pigmentation (P = 0.0013, and P = 0.0005), but no other photoprotective effect was observed across the repurposed groups. This study demonstrates that oral supplementation with bucillamine, carvedilol, metformin, or phenformin does not affect UVR-induced carcinogenesis in hairless mice.</p

Immune Modulating Topical S100A8/A9 Inhibits Growth of Pseudomonas aeruginosa and Mitigates Biofilm Infection in Chronic Wounds

Pseudomonas aeruginosa biofilm maintains and perturbs local host defense, hindering timely wound healing. Previously, we showed that P. aeruginosa suppressed S100A8/A9 of the murine innate host defense. We assessed the potential antimicrobial effect of S100A8/A9 on biofilm-infected wounds in a murine model and P. aeruginosa growth in vitro. Seventy-six mice, inflicted with a full-thickness burn wound were challenged subcutaneously (s.c.) by 106 colony-forming units (CFUs) of P. aeruginosa biofilm. Mice were subsequently randomized into two treatment groups, one group receiving recombinant murine S100A8/A9 and a group of vehicle controls (phosphate-buffered saline, PBS) all treated with s.c. injections daily for up to five days. Wounds were analyzed for quantitative bacteriology and contents of key inflammatory markers. Count of blood polymorphonuclear leukocytes was included. S100A8/A9-treatment ameliorated wound infection, as evaluated by quantitative bacteriology (p ≤ 0.05). In vitro, growth of P. aeruginosa was inhibited dose-dependently by S100A8/A9 in concentrations from 5 to 40 μg/mL, as determined by optical density-measurement (OD-measurement) and quantitative bacteriology. Treatment slightly augmented key inflammatory cytokine Tumor Necrosis Factor-α (TNF-α), but dampened interferon-γ (IFN-γ) levels and blood polymorphonuclear count. In conclusion, topical S100A8/A9 displays remarkable novel immune stimulatory and anti-infective properties in vivo and in vitro. Importantly, treatment by S100A8/A9 provides local infection control. Implications for a role as adjunctive treatment in healing of chronic biofilm-infected wounds are discussed

Keratinocyte Carcinoma and Photoprevention:The Protective Actions of Repurposed Pharmaceuticals, Phytochemicals and Vitamins

SIMPLE SUMMARY: Keratinocyte carcinoma is the most common type of cancer. Sun exposure and ultraviolet radiation are significant contributors to the development of carcinogenesis, mediated by DNA damage, increased oxidative stress, inflammation, immunosuppression and dysregulated signal transduction. Photoprevention involves using different compounds to delay or prevent ultraviolet radiation-induced skin cancer. In this review, we look at new avenues for systemic photoprevention that are based on pharmaceuticals, plant-derived phytochemicals and vitamins. We also investigate the mechanisms underlying these strategies for preventing the onset of carcinogenesis. ABSTRACT: Ultraviolet radiation (UVR) arising from sun exposure represents a major risk factor in the development of keratinocyte carcinomas (KCs). UVR exposure induces dysregulated signal transduction, oxidative stress, inflammation, immunosuppression and DNA damage, all of which promote the induction and development of photocarcinogenesis. Because the incidence of KCs is increasing, better prevention strategies are necessary. In the concept of photoprevention, protective compounds are administered either topically or systemically to prevent the effects of UVR and the development of skin cancer. In this review, we provide descriptions of the pathways underlying photocarcinogenesis and an overview of selected photoprotective compounds, such as repurposed pharmaceuticals, plant-derived phytochemicals and vitamins. We discuss the protective potential of these compounds and their effects in pre-clinical and human trials, summarising the mechanisms of action involved in preventing photocarcinogenesis