105 research outputs found
Risk of severe dengue is higher in patients with sickle cell disease: a scoping review.
- Author
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 24/01/2019
- Field of study
CFTR founder mutation causes protein trafficking defects in Chinese patients with cystic fibrosis
- Author
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2017
- Field of study
published_or_final_versio
Genetic adult lactase persistence is associated with risk of Crohn's Disease in a New Zealand population
- Author
- Alan G Fraser
- Angharad R Morgan
- C Büning
- Deborah J Nolan
- Dug Yeo Han
- I Abubakar
- I Shrier
- IR Grant
- IR Grant
- JE Lennard-Jones
- JE Wigginton
- Linda C Tapsell
- Lynnette R Ferguson
- M Kerber
- N Phavichitr
- NS Enattah
- P Munkholm
- P Ridefelt
- PD Sasieni
- R Shoda
- RA Juste
- RA Juste
- RB Gearry
- RH Lewinsky
- RJ Greenstein
- RW Bentley
- RW Sweeney
- RWL Leong
- SA Naser
- SA Tishkoff
- T Sahi
- TH Vesa
- TJ Bull
- W Chamberlin
- Wen Jiun Lam
- WY Ayele
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
Background: Mycobacterium avium subspecies paratuberculosis (MAP) is an infective agent found in ruminants and milk products, which has been suggested to increase the risk of gastrointestinal inflammation in genetically susceptible hosts. It is hypothesized that lactase persistence facilitates exposure to such milk products increasing the likelihood of adverse outcomes. Individuals either homozygous or heterozygous for the T allele of DNA variant, rs4988235, located 14kb upstream from the LCT locus, are associated with having lactase persistence. The aim of this study was to determine whether lactase persistence as evident by the T allele of rs4988235 is associated with Crohn's Disease (CD) in a New Zealand population. Findings: Individuals homozygous for the T allele (T/T genotype) showed a significantly increased risk of having CD as compared with those homozygous for the C allele (OR = 1.61, 95% CI = 1.03-2.51). Additionally, a significant increase in the frequency of the T allele was observed in CD patients (OR = 1.30, 95% CI = 1.05-1.61, p = 0.013), indicating that the T allele encoding lactase persistence was associated with an increased risk of CD. Conclusions: Our findings indicate that lactase persistence as evident by the presence of the T allele of rs4988235 is associated with risk of CD in this New Zealand Caucasian population
Is Breast Cancer the Same Disease in Asian and Western Countries?
- Author
- A Jemal
- A Mathew
- AM Ugnat
- Anna Derossis
- AY El-Bastawissi
- BO Anderson
- C Nagata
- CI Neutel
- CK Gajalakshmi
- CM Perou
- CodyHS Laughlin
- D Berry
- DW Parkin
- E Giuliano
- E Ward
- F Bray
- G Agarwal
- G Agarwal
- G Agarwal
- G Ursin
- GA Porter
- Gaurav Agarwal
- GF Schwartz
- GM Leung
- GN Hortobagyi
- H Senn
- Hiram Cody
- I Mittra
- J Clemmesen
- J Sariego
- JemalA SR
- JS Lawson
- K Shibuya
- KA Dinshaw
- KC Chu
- Kerstin Sandelin
- L Bergkvist
- L Bergkvist
- LA Gaudette
- LM Anderson
- M Green
- M Halmin
- M McCracken
- M Tewari
- MC Pike
- MG del Carmen
- N Shen
- Nam-Sun Paik
- National Cancer Registry Program Indian Council of Medical Research
- National Cancer Registry Program Indian Council of Medical Research
- NS Murthy
- P Porter
- PL Porter
- R Chopra
- RK Matsuno
- S Kuraparthy
- SB Edge
- SH Ahn
- Stanley P. L. Leong
- T Tajima
- The Korean Breast Cancer Society
- The Korean Breast Cancer Society
- The Korean Breast Cancer Society
- TJ Liu
- TJ Liu
- Tomoo Tajima
- Tse-Jia Liu
- V Aggarwal
- V Raina
- VW Setiawan
- WF Anderson
- WF Anderson
- William D. Foulkes
- WY Chen
- X Sim
- Y Yasui
- Zhen-Zhou Shen
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2010
- Field of study
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.
- Author
- Adair LS
- Adeyemo A
- Aguilar-Salinas CA
- Ahlqvist E
- Ahluwalia TS
- Ahsan H
- An P
- Anand SS
- Arruda AL
- Becker DM
- Below JE
- Bertoni A
- Bharadwaj D
- Bielak LF
- Bocher O
- Boehnke M
- Bonnefond A
- Bork-Jensen J
- Bowden DW
- Bragg F
- Brandslund I
- Broadaway KA
- Brody JA
- Buchanan TA
- Burant CF
- Butterworth AS
- Cade BE
- Canouil M
- Chai J-F
- Chambers JC
- Chan JCN
- Chandak GR
- Chang K-M
- Chang L-C
- Chee M-L
- Chen C-H
- Chen G
- Chen J
- Chen S-H
- Chen W-M
- Chen Y-DI
- Chen Y-T
- Chen Z
- Cheng C-Y
- Cho YS
- Choi HS
- Chuang L-M
- Collins FS
- Cook JP
- Cruz M
- Cui J
- Cushman M
- Danesh J
- Das SK
- de Silva HJ
- Dedoussis G
- Denny JC
- Dimitrov L
- Doumatey AP
- Du S
- Duan Q
- Dupuis J
- Eckardt K-U
- Emery LS
- Engert JC
- Evans DS
- Evans MK
- Finer S
- Fischer K
- Florez JC
- Floyd JS
- Ford I
- Fornage M
- Franco OH
- Frayling TM
- Freedman BI
- Froguel P
- Genter P
- Gerstein HC
- Ghanbari M
- Giedraitis V
- Gieger C
- González-Villalpando C
- González-Villalpando ME
- Goodarzi MO
- Gordon-Larsen P
- Graff M
- Grallert H
- Grarup N
- Gross M
- Guare LA
- Guo X
- Hackinger S
- Hai Y
- Haiman CA
- Hakaste L
- Han S
- Hanis CL
- Hansen T
- Hattersley AT
- Hatzikotoulas K
- Hayes MG
- Herder C
- Horikoshi M
- Howard A-G
- Hsueh W
- Huang M
- Huang W
- Huerta-Chagoya A
- Hung Y-J
- Hwang MY
- Hwu C-M
- Ichihara S
- Igase M
- Ikram MA
- Ingelsson E
- Ingelsson M
- Ipp E
- Islam MT
- Isono M
- Jang H-M
- Jasmine F
- Jiang G
- Jonas JB
- Joo YY
- Jukema JW
- Jørgensen T
- Kabagambe E
- Kadowaki T
- Kals M
- Kamali Z
- Kamanu FK
- Kandeel FR
- Kanoni S
- Kardia SLR
- Kasturiratne A
- Kato N
- Katsuya T
- Kaur V
- Kawaguchi T
- Keaton JM
- Kho AN
- Khor C-C
- Kibriya MG
- Kim B-J
- Kim D-H
- Kim YJ
- Koh W-P
- Kooner JS
- Kooperberg C
- Kronenberg F
- Kuusisto J
- Kwak S-H
- Köttgen A
- Laakso M
- Lamri A
- Lange LA
- Langenberg C
- Lee J
- Lee J-J
- Lee KM
- Lee M-S
- Lee NR
- Lee SSK
- Leong A
- Li L
- Li Y
- Li-Gao R
- Ligthart S
- Lim VJY
- Lin K
- Lind L
- Lindgren CM
- Linneberg A
- Liu C-T
- Liu J
- Liu S
- Liu Y
- Locke AE
- Long J
- Loos RJF
- Lorenz KM
- Louie T
- Luan J
- Luk AO
- Luo X
- Lv J
- Lynch JA
- Lyssenko V
- Läll K
- Ma RCW
- Maeda S
- Mahajan A
- Mamakou V
- Mandla R
- Mansuri SR
- Marston NA
- Matsuda F
- Matsuda K
- McCarthy MI
- McKean-Cowdin R
- Meigs JB
- Meitinger T
- Melander O
- Melloni GEM
- Mercader JM
- Metspalu A
- Millwood IY
- Mo H
- Mohlke KL
- Mook-Kanamori DO
- Moon S
- Morris AD
- Morris AP
- Motala AA
- Moura FA
- Mägi R
- Nadler JL
- Nakatochi M
- Nalls MA
- Namba S
- Nano J
- Nayak U
- Ng MCY
- Nicolas A
- Nongmaithem SS
- Noordam R
- North KE
- Nousome D
- Ntalla I
- Okada Y
- Orozco L
- Palmer CNA
- Pan I
- Pankow JS
- Park K-S
- Parra EJ
- Paré G
- Patel SR
- Patil S
- Pedersen O
- Pei P
- Pereira MA
- Peters A
- Petty LE
- Peyser PA
- Pirie FJ
- Polikowsky HG
- Porneala B
- Prasad G
- Preuss MH
- Prins BP
- Province MA
- Psaty BM
- Rader DJ
- Raffel LJ
- Raffield LM
- Rasmussen-Torvik LJ
- Rayner NW
- Redline S
- Reiner AP
- Rich SS
- Ritchie MD
- Roden M
- Rohde R
- Roll K
- Rotimi CN
- Rotter JI
- Ruff CT
- Sabanayagam C
- Sale MM
- Saleheen D
- Sandow K
- Sankareswaran A
- Sarnowski C
- Sattar N
- Schroeder P
- Schönherr S
- Scott RA
- Shahriar M
- Shen B
- Sheu WHH
- Shi J
- Shin DM
- Shojima N
- Shu X-O
- Sim X
- Smith JA
- So WY
- Sofer T
- Sonehara K
- Southam L
- Spracklen CN
- Stančáková A
- Stefansson K
- Steinthorsdottir V
- Stilp AM
- Strauch K
- Sun M
- Suzuki K
- Tabara Y
- Tai E-S
- Takeuchi F
- Taliun D
- Tam CHT
- Tan J
- Taylor HJ
- Taylor KD
- Thangam M
- Thorand B
- Thorleifsson G
- Thorsteinsdottir U
- Tomlinson B
- Tong L
- Tran TC
- Trompet S
- Tsai F-J
- Tsao PS
- Tuomi T
- Tuomilehto J
- Tusie-Luna T
- Udler MS
- VA Million Veteran Program
- Valladares-Salgado A
- van Dam RM
- van Dijk KW
- van Heel DA
- van Klinken JB
- Vanderwerff B
- Varma R
- Voight BF
- Vujkovic M
- Wacher-Rodarte N
- Walters RG
- Wang Y-X
- Wareham NJ
- Wheeler E
- Wickremasinghe AR
- Williamson A
- Wilson JG
- Witte DR
- Wong T-Y
- Wu J-Y
- Wuttke M
- Xiang AH
- Yajnik CS
- Yamamoto K
- Yamamoto K
- Yamauchi T
- Yanek LR
- Yao J
- Yin X
- Yokota M
- Yoon K
- Yu C
- Yuan J-M
- Yusuf S
- Zawistowski M
- Zeggini E
- Zhang L
- Zhang W
- Zheng W
- Zonderman AB
- Zöllner S
- Publication venue
- Nature Research
- Publication date
- 19/02/2024
- Field of study
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P < 5 × 10-8) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores5 in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care
ICAR: endoscopic skull‐base surgery
- Author
- Aaron G
- Aaron GP
- Abergel A
- Abouaf L
- Abrishamkar S
- Acioly MA
- Acioly MA
- Acuna RT
- Adams AS
- Adappa ND
- Aferzon M
- Agaimy A
- Agarwal A
- Aggarwal A
- Agrawal D
- Ahmed OH
- Aihara M
- Akagami R
- Alahmadi H
- Albu S
- Albu S
- Albu S
- Alexander A
- Alimohamadi M
- Almefty R
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almond MC
- Alobaid A
- Alobid I
- Alobid I
- Alos L
- AlQahtani A
- Altay T
- Alvarez FL
- Alves MV
- Al‐Mamgani A
- Al‐Mefty O
- Al‐Sheibani S
- Amano K
- Amdur RJ
- Amelot A
- American Academy of Pediatrics Steering Committee on Quality Improvement and Management
- Amichetti M
- Amin SM
- Amit M
- Amit M
- Amit M
- Ammirati M
- Anari S
- Anderson D
- Anderson RL
- Andrade NA
- Andrews JC
- Anik I
- Ansa B
- Ansari M
- Antonelli AR
- Arafah BM
- Arafah BM
- Arafah BM.
- Arai A
- Arat YO
- Arbolay OL
- Ardehali MM
- Armengot M
- Arnautovic KI
- Arrer E
- Arslan HH
- Aryan HE
- Asano S
- Askoxylakis V
- Astrup J
- Awad AJ
- Awad M
- Azad TD
- Aziz KM
- Babin E
- Bachmann G
- Back L
- Backlund EO.
- Baijal V
- Balaker AE
- Ballah D
- Balzer JR
- Banks CA
- Banu MA
- Banu MA
- Banuchi VE
- Barnes L
- Baser B
- Baskin DS
- Battaglia P
- Battaglia P
- Becker AM
- Beckhardt RN
- Bedi AD
- Bedrosian JC
- Bedrosian JC
- Beer‐Furlan A
- Beer‐Furlan A
- Beham A
- Bejjani GK
- Bell D
- Bell RB
- Bell RB
- Berdahl JP
- Berhouma M
- Berker M
- Berker M
- Berkmann S
- Berkmann S
- Berkmann S
- Bernal‐Sprekelsen M
- Bernal‐Sprekelsen M
- Bernat AL
- Bertrand B
- Bhasker S
- Bhatti SN
- Bidot S
- Bills DC
- Bishop JA
- Biswas D
- Black PM
- Bleier BS
- Bleier BS
- Bleier BS
- Bleier BS
- Bleier BS
- Bloch C
- Bloch O
- Bly RA
- Boghani Z
- Bohman LE
- Bohman LE
- Bokhari AR
- Boling CC
- Bolzoni Villaret A
- Borg A
- Borghei P
- Boukheris H
- Brackmann DE
- Bradley PJ
- Branston NM
- Brastianos PK
- Bremer JW
- Bresson D
- Briet C
- Briggs RJ
- Brodie HA.
- Brown SM
- Bruchhage KL
- Brucker‐Davis F
- Brunworth J
- Buchmann L
- Buerke B
- Bujawansa S
- Bumm K
- Bunin GR
- Burman P
- Butler S
- Butros SR
- But‐Hadzic J
- Caballero N
- Caicedo‐Granados E
- Caldarelli M
- Campbell E
- Campbell PG
- Campbell RG
- Capatina C
- Cappabianca P
- Cappabianca P
- Cappabianca P
- Cappabianca P
- Cappabianca P
- Cappabianca P
- Carlson ML
- Carmel P
- Carrau RL
- Carrillo JF
- Carter KB
- Carvalho P
- Cassano M
- Castelnuovo P
- Castelnuovo P
- Castelnuovo P
- Catapano G
- Cathelinaud O
- Cavalheiro S
- Cavallo LM
- Cavallo LM
- Cavallo LM
- Cavallo LM
- Cavallo LM
- Cavallo LM
- Cavallo LM
- Cavallo LM
- Cavallo LM
- Cebula H
- Ceylan S
- Ceylan S
- Ceylan S
- Chaaban MR
- Chaaban MR
- Chaaban MR
- Chaaban MR
- Chabot JD
- Chabot JD
- Chan JY
- Chan KH
- Chandler JR
- Chandra RK
- Chanson P
- Chapman PR
- Chapurlat RD
- Charlett SD
- Chauvet D
- Chegini S
- Chen AM
- Chen C
- Chen J
- Chen JC
- Chen L
- Chen LF
- Chen MK
- Chen MK
- Chen MY
- Chen MY
- Chen ZY
- Cheng Y
- Chhabra N
- Chhabra N
- Chi F
- Chibbaro S
- Chibbaro S
- Chin CJ
- Chin OY
- Chiou SM
- Chiu AG
- Cho DY
- Cho JM
- Cho YH
- Choby GW
- Choi D
- Choi M
- Chowdhury FH
- Christopherson K
- Chung TK
- Chung WY
- Ciporen JN
- Ciric I
- Ciric I
- Clark AJ
- Clark AJ
- Clavenna MJ
- Clemenza JW
- Clifford‐Jones RE
- Cloutier T
- Cobb MI
- Coburger J
- Cohen AR
- Cohen S
- Colli BO
- Combs SE
- Combs SE
- Commins DJ
- Comtois R
- Conger BT
- Costantino PD
- Cote DJ
- Crockard HA
- Cummings BJ
- Cushing H.
- Cushing H.
- Cutler AR
- D'Anza B
- Dagi TF
- Dai CX
- Dalgic A
- Dallan I
- Danesi G
- Daniels AB
- Daraei P
- Daudia A
- Davies BM
- Deconde AS
- Dedmon M
- Deep NL
- Dehdashti AR
- Dehdashti AR
- Dehdashti AR
- Dehdashti AR
- DeKlotz TR
- DeKlotz TR
- Del Monte P
- DelGaudio JM.
- Demarco RC
- Demetriades D
- Demiroz C
- der Laan TP
- der Laan TP
- Derome PJ
- Derrey S
- Dhaliwal SS
- Dhanasekar G
- Dhandapani S
- Di Maio S
- Di Rocco C
- DiNardo LJ
- Divitiis E
- Divitiis E
- Divitiis E
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- Dlouhy BJ
- Dolati P
- Dolci RLL
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- Drange MR
- Dubey SP
- Dulguerov P
- Durgam A
- Dusick JR
- Dusick JR
- Earwaker J
- Eboli P
- Effenterre R
- Eftekhar B
- Efune G
- Ejaz A
- El Morsy SM
- El Sharkawy AA.
- El Shazly AA
- Elangovan C
- Eljamel MS
- Eljamel MS.
- Eljamel MS.
- Ellegala DB
- Eller R
- Ellington CL
- Elliott RE
- Eloy JA
- Eloy JA
- Eloy JA
- Eloy JA
- Eloy JA
- Eloy JA
- Eloy JA
- Eloy P
- Elsasser Imboden PN
- Elshazly K
- el‐Guindy A
- El‐Sayed IH
- Emanuelli E
- Emanuelli E
- Erdem E
- Eseonu CI
- Esposito F
- Eytan DF
- Fahlbusch R
- Famularo G
- Fan J
- Fandino M
- Faria MA
- Fatemi N
- Fatemi N
- Fathalla H
- Fathalla H
- Felippu A
- Felix‐Ravelo M
- Feng L
- Fernandes Cabral DT
- Fernandez‐Miranda JC
- Fernandez‐Miranda JC
- Ferrante E
- Fields JN
- Firooznia H
- Fisch U
- Fischbein NJ
- Fischer EG
- Fishpool SJ
- Fiss I
- Fitzek MM
- Flannery TJ
- Fleischman GM
- Fleseriu M
- Fleseriu M
- Folbe AJ
- Fomichev D
- Fonseca AS
- Fortes FS
- Franchi A
- Frank G
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- Frank G
- Frank G
- Fraser JF
- Fraser JF
- Fraser S
- Fraser S
- Frassanito P
- Frazee RC
- Fried D
- Friedman DI
- Friedman JA
- Friedman JA
- Frierson HF
- Fu TS
- Fu TS
- Fujii K
- Fujita Y
- Fukuda M
- Fyrmpas G
- Gadgil N
- Gagliardi F
- Gallagher KK
- Gallagher MJ
- Gandhoke GS
- Ganseman A
- Garcia T
- Garcia‐Navarro V
- Gardner PA
- Gardner PA
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- Gardner PA
- Gardner PA
- Gardner PA
- Garofalo P
- Garzaro M
- Gay E
- Gaynor BG
- Gazzeri R
- Gazzeri R
- Gelbard A
- Georgalas C
- Georgalas C
- Gerganov V
- Gerlach R
- Germani RM
- Ghosh A
- Giannoni CM
- Gil Z
- Gil Z
- Gilat H
- Giustina A
- Glicksman JT
- Godoy MD
- Goel A
- Goepfert H
- Golding‐Wood PH
- Golinelli G
- Gompel JJ
- Gondim JA
- Gondim JA
- Gondim JA
- Gonzalez Briceno L
- Gorelick J
- Gorner M
- Gosal JS
- Gossman DG
- Goudakos JK
- Gousias K
- Graffeo CS
- Gray ST
- Grayson JW
- Greig SR
- Griffith AJ
- Gruss CL
- Guadagno E
- Guiot G.
- Gupta AK
- Gurcay AG
- Hackman T
- Hackman TG.
- Hadad G
- Hadad G
- Haerle SK
- Haidar H
- Hajiabadi M
- Halderman A
- Hall ED.
- Halvorsen H
- Hama S
- Hameed AS
- Hammami B
- Han ZL
- Hanna E
- Hanson M
- Hardy J
- Hardy J
- Harper CM
- Harvey RJ
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- Harvey RJ
- Harvey RJ
- Harvey RJ
- Harvey RJ
- Hasegawa H
- Hasegawa T
- Hasegawa T
- Havenbergh T
- Hayhurst C
- Hazarika P
- Healy DY
- Hegazy HM
- Heo KW
- Heredero S
- Hetelekidis S
- Hide T
- Higgins TS
- Higham CE
- Hill CA
- Hines JP
- Hirsch O.
- Hlavica M
- Ho AS
- Hoffman HJ
- Hofmann BM
- Hofmann BM
- Hofmann T
- Hofstetter CP
- Holsken A
- Holzmann D
- Honegger J
- Hong CK
- Hong Jiang W
- Hong SD
- Hong SD
- Hong SD
- Horiguchi K
- Horiguchi K
- Horridge M
- Hosemann W
- Hosokawa S
- Hota A
- Howard DJ
- Howard DJ
- Hsu CY
- Hsu NI
- Hu F
- Huang Y
- Hudgins PA
- Hughes JD
- Hukin J
- Hunter JB
- Hunter JB
- Huntley C
- Husain Q
- Husain Q
- Hussain I
- Hwang DJ
- Hwang PH
- Hwang PY
- Hyun DW
- Iacoangeli M
- Iannalfi A
- Iannelli A
- Ibrahim AA
- Ikeda K
- Ikeda K
- Illing E
- Illing EA
- Iloreta AM
- Imre A
- Inamasu J
- Isaacson B
- Isenberg SF
- Issing PR
- Ito E
- Ivan ME
- Jaberoo MC
- Jackson AS
- Jacob AK
- Jacob M
- Jacquesson T
- Jacquesson T
- Jagannathan J
- Jahangiri A
- Jahangiri A
- Jahangiri A
- Jakimovski D
- Jalessi M
- Jalessi M
- Janakiram N
- Janakiram TN
- Jane JA
- Jane JA
- Jane JA
- Jang JH
- Jang TY
- Jang WY
- Jeng YM
- Jeon C
- Jeon C
- Jeswani S
- Jethwa PR
- Jho HD
- Jho HD
- Jho HD
- Jiang RS
- Jiang W
- Jones PS
- Jones V
- Jorissen M
- Jouanneau E
- Julow J
- Julow J
- Jung CS
- Jung TY
- Juraschka K
- Kadish S
- Kahilogullari G
- Kalani MY
- Kalinin PL
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- Publication venue
- Publication date
- 01/07/2019
- Field of study
n/
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
- A Aydin
- A Balcerczyk
- A Besarab
- A Brzezinski
- A Campbell
- A Carrillo-Vico
- A Cavalli
- A Chattopadhyay
- A Chattopadhyay
- A Cherubini
- A Dey
- A Doms
- A Donovan
- A Donovan
- A Dávalos
- A Gaeta
- A Garny
- A Gnjec
- A Gomes
- A Gopalakrishnan
- A Hald
- A Henney
- A Hirayama
- A Hoffmann
- A Huber
- A Hugman
- A Iannetti
- A Ide-Ektessabi
- A Jacobs
- A Jeyabalan
- A Kahvejian
- A Karrar
- A Kasztler
- A Kibel
- A Kocyigit
- A Kotha
- A Kumral
- A Lass
- A Lecube
- A Lewén
- A Lotery
- A Maggio
- A Malek
- A Malik
- A Mantovani
- A Matsuzawa
- A Mitra
- A Monge
- A Murakami
- A Murakami
- A Murakami
- A Murakami
- A Mutti
- A Nijnik
- A Nunomura
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- A Patt
- A Persson
- A Pietrangelo
- A Piga
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- A Scalbert
- A Scalbert
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- A Stintzi
- A Szewczyk
- A Taguchi
- A Tedgui
- A Terman
- A Terman
- A Terman
- A Undas
- A Virdis
- A Wagner
- A Wagner
- A Wagner
- A Wagner
- A Wojas-Pelc
- A Wong
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- A Yoritaka
- A Yoshimura
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- Ad hoc committee on systemic lupus erythematosus response criteria for fatigue
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- B Chakravarti
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- T Amit
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- TG Kazi
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- The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
- TJ Gibson
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- TK Kvien
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- TO Scholl
- TO Scholl
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- TT Lao
- TT Lao
- TW Jung
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- U Alon
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- U Buescher
- U Cha'on
- U Eckstein-Ludwig
- U Heinz
- U Laufs
- U Schönbeck
- UN Das
- V Adam-Vizi
- V Adam-Vizi
- V Atanasiu
- V Braun
- V Braun
- V Calabrese
- V Campuzano
- V Campuzano
- V Curcin
- V Emilsson
- V Fellman
- V Gabutti
- V Gordeuk
- V Hower
- V Hvidberg
- V Irazusta
- V Irazusta
- V Kaushal
- V Lahera
- V Prinz
- V Shulaev
- V Siffrin
- V Srinivasan
- VA Kostyuk
- VB O'Donnell
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- VL Kinnula
- VL Kinnula
- VM Campese
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- VR Gordeuk
- VR Gordeuk
- VR Taqueti
- W Aerbajinai
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- W Hu
- W Kalt
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- W Ma
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- WA Cass
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- WJ Jo
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- WS Jeong
- WS Yang
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- WW Wong
- WY Ong
- X Chen
- X Chen
- X He
- X Huang
- X Huang
- X Huang
- X Li
- X Zhang
- X Zhu
- X Zhu
- XD Huang
- XJ Li
- XM Yuan
- XM Yuan
- XP Huang
- Y Almog
- Y Avramovich-Tirosh
- Y Bao
- Y Bdolah
- Y Chen
- Y Christen
- Y Curin
- Y Deugnier
- Y Deugnier
- Y Engin-Üstün
- Y Ge
- Y Gilgun-Sherki
- Y Haruna
- Y Honda
- Y Hua
- Y Ikeda
- Y Jiao
- Y Jung
- Y Ke
- Y Ke
- Y Kohgo
- Y Kohgo
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- Y Li
- Y Okatani
- Y Okatani
- Y Sai
- Y Sai
- Y Sun
- Y Takada
- Y Wang
- Y Wang
- Y Wei
- Y Wei
- Y Wu
- Y Wu
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhao
- Y Zheng
- YE Henrotin
- YF Chu
- YH Lee
- YH Suh
- YH Wei
- YJ Surh
- YJ Surh
- YJ Surh
- YK Wu
- YM Kim
- YS Keum
- YS Sohn
- YX Ma
- YZ Fang
- Z Cai
- Z Cai
- Z Cheng
- Z Pei
- Z Serdar
- Z Tong
- Z Tong
- Z Yu
- Z Zhang
- ZD Liu
- ZD Liu
- ZE Karanjawala
- ZE Suntres
- ZI Cabantchik
- ZZ Chong
- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Infectious diseases in allogeneic haematopoietic stem cell transplantation: prevention and prophylaxis strategy guidelines 2016
- Author
- A Barra
- A Berglund
- A Gafter-Gvili
- A Glasmacher
- A Glasmacher
- A Hata
- A Josephson
- A Knoll
- A Knoll
- A Locasciulli
- A Locasciulli
- A Meerbach
- A Meerveld-Eggink
- A Nagler
- A Oza
- A Sauerbrei
- A Sauerbrei
- A Stern
- A Tamori
- A Tomonari
- A Zirakzadeh
- AA Eijk van der
- AB Narvios
- AB Narvios
- AC Norlin
- AJ Ullmann
- American Academy of Pediatrics Committee on Infectious Diseases
- Andrew J. Ullmann
- B Allegranzi
- B Gruhn
- B Hayes-Lattin
- BJ Liss
- BJ McMahon
- C Chan
- C Colby
- C Cordonnier
- C Cordonnier
- C Cordonnier
- C Cordonnier
- C Cordonnier
- C Cordonnier
- C Cordonnier
- C Garcia-Vidal
- C Gilbert
- C Katlama
- C Katlama
- C Leport
- C McLaren
- Centers for Disease C. and Prevention
- CL Davis
- CM Rooney
- CR Li
- CS Han
- CU Foppa
- D Bedognetti
- D Engelhard
- D Engelhard
- D Jaffe
- D Menzies
- D Neofytos
- D Podzamczer
- D Toneatto
- DH Kim
- DJ Winston
- DJ Winston
- DJ Winston
- DM Weinstock
- DP Kontoyiannis
- DS Stein
- DW Bates
- E Ayala
- E Gluckman
- E Vance
- E Whimbey
- EC Guinan
- EC McWilliam Leitch
- EJ Ariza-Heredia
- ER Dubberke
- FM Marty
- FM Marty
- G Avetisyan
- G Bucaneve
- G Chamilos
- G Daeschlein
- G Hutter
- G Hutter
- G Hutter
- Georg Maschmeyer
- Gerda Silling
- GF Behre
- GJ Mertz
- GK Lau
- GS Taylor
- H Bertz
- H Einsele
- H Einsele
- H Einsele
- H Einsele
- H Fricker-Hidalgo
- H Green
- H Humphreys
- H Inaba
- H Kalies
- H Lavallade de
- H Link
- H Mitsui
- H Olkinuora
- Hartmut Bertz
- HC Rumke
- Hermann Einsele
- HN Kim
- I Hilgendorf
- I Oren
- IA Tabbara
- IZ Tuan
- J Beran
- J Leong
- J Piret
- J Ruskin
- J Shang
- J Sinko
- J Tung
- J Versluis
- J Yan
- JA Burik van
- JA Maertens
- JA Stewart
- JA Zaia
- JA Zaia
- JB Pinson
- JC Wade
- JC Wade
- JD Meyers
- JD Meyers
- JH Lee
- JL Goodman
- JM Costa
- JP Kerr
- JP Souza
- JR Wingard
- JS Cervia
- JS Koskinas
- JT Poolman
- JW Hiemenz
- Jörg Janne Vehreschild
- K Cortez
- K Fahlgren
- K Kawamura
- K Matsue
- K Micklethwaite
- K Wessel van
- KA Marr
- KA Marr
- KJ Thomson
- KM Edwards
- KM Sullivan
- KM Williams
- L Leibovici
- L Ochs
- L Ostrosky-Zeichner
- LC Lambert
- LF Verdonck
- LJ Burns
- M Boeckh
- M Boeckh
- M Boeckh
- M Boeckh
- M Cornet
- M Cruciani
- M Cullen
- M Hamadani
- M Mikulska
- M Mikulska
- M Onozawa
- M Pao
- M Pompili
- M Roghmann
- M Schmidt-Hieber
- M Schmidt-Hieber
- M Schmidt-Hieber
- M Thouverez
- M Vusirikala
- MA Kharfan-Dabaja
- MA Slavin
- Martin Schmidt-Hieber
- MB Mahler
- MC Dignani
- MC Sneller
- Michael Kiehl
- MJ Post
- MJ Ruping
- MJ Vasconcelles
- MM Schneider
- N Castro De
- N Dhedin
- N Kekre
- N Kroger
- N Lehners
- NC Issa
- NI Paphitou
- NM Boyle
- O Lyytikainen
- O Penack
- OA Cornely
- OA Cornely
- OA Cornely
- Olaf Penack
- P Coutre le
- P Fabritiis de
- P Frere
- P Ljungman
- P Ljungman
- P Ljungman
- P Ljungman
- P Ljungman
- P Ljungman
- P Ljungman
- P Mahale
- P Raanani
- P Raanani
- P Reusser
- P Robinson
- P Zhang
- P Zikos
- PC Begue
- Q Liu
- R Idilman
- R Liang
- R Liang
- R Loomba
- R Martino
- R Peffault de Latour
- R Peffault de Latour
- R Saral
- R Seggewiss
- RA Bowden
- RA Bowden
- RA Eisenberg
- RD Harrington
- RE Curtis
- RE Lewis
- RF Chemaly
- RF Duarte
- RM Locksley
- RP Wenzel
- S Blot
- S Bretagne
- S Gueller
- S Gupta
- S Jacobsson
- S Kimura
- S Kulkarni
- S Li Volti
- S Li Volti
- S McCann
- S Mousset
- S Nader
- S O’Brien
- S Vokurka
- Sabine Mousset
- SC Kussmaul
- SE Moses
- SH Oertel
- Silke Neumann
- SK Tyring
- SM Kelsey
- SM King
- SM Moon
- SM Raboni
- SP Hammond
- SP Hammond
- SR Burrows
- SR Patel
- Stefan Neuburger
- T Aoki
- T Chiba
- T Eckmanns
- T Parkkali
- T Parkkali
- T Parkkali
- T Parkkali
- T Parkkali
- T Ruutu
- T Thiele
- T Witte De
- TJ Dengler
- TJ Henrich
- TJ Liang
- TK Marras
- TT Chang
- U Gerdemann
- V Balloy
- V Erard
- V Erard
- V Roy
- V Spoulou
- W Hughes
- W Yeo
- Werner J. Heinz
- WH Kruger
- William Krüger
- WJ Miller
- WM El-Sadr
- WT Hughes
- WT Hughes
- WY Au
- Y Asano-Mori
- Y Kanda
- Y Koc
- Y Shono
- Y Taur
- Y Taur
- YM Lee
- ZY Zhou
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Low-order estimation scheme for large-scale systems with interconnection delays
- Publication venue
- 'Institute of Electrical and Electronics Engineers (IEEE)'
- Publication date
- 01/01/2014
- Field of study
This paper deals with the practical aspects of reduced-order distributed functional state observers design for interconnected linear systems subject to time delays in the interconnections. Contrary to some estimation strategies which only take the ideal instantaneous output information into account, the proposed scheme incorporates output information that is inevitably encountered with time delays in the course of its transmission from the distanced subsystems. It is proved that such estimator possesses less restrictive existence conditions with the acceptance of measurement data from other interrelated subsystems. Upon the satisfaction of the established existence conditions, it will be demonstrated through a simple design procedure and simulation results that a feasible observer can be realized for a given numerical system
The current status of prophylactic femoral intramedullary nailing for metastatic cancer
- Publication venue
- 'Ecancer Global Foundation'
- Publication date
- Field of study
- …