ALICE Diffractive Detector Control System for RUN-II in the ALICE Experiment

This paper describes general characteristics of the deployment and commissioned of the Detector Control System (DCS) AD0 for the second phase of the Large Hadron Collider (LHC). The AD0 detector is installed in the ALICE experiment to provide a better selection of diffractive events.Comment: 4 pages, 5 figures, To be published in Journal of Physics Conference Series (IOP). Joint Proceedings of the XV Mexican Workshop on Particles and Fields & the XXX Annual Meeting of the Division of Particles and Fields of the Mexican Physical Societ

Calidad de atención y satisfacción del usuario del Servicio de Referencias y Contrarreferencias de un hospital, Lima, 2023

Un servicio eficiente, bien coordinado y centrado en la comunicación y el cuidado del paciente contribuye no solo a la satisfacción inmediata, sino también a la confianza continua en el sistema de salud y a una experiencia positiva en el cuidado médico. El propósito de este estudio fue examinar la correlación entre la calidad de atención y la satisfacción de los usuarios del servicio de referencias y contrarreferencias de un hospital en Lima en 2023. Se aplicó un enfoque cuantitativo y se llevó a cabo una investigación aplicada utilizando un diseño no experimental y correlacional. La muestra consistió en 120 usuarios, obtenidos mediante la fórmula para poblaciones conocidas, y se utilizó la encuesta como método de recolección. El instrumento fue por medio del cuestionario, uno con 19 ítems y otro con 22 ítems. Los resultados, analizados a través de la prueba estadística Rho Spearman, indicaron una relación significativa entre la calidad de atención y la satisfacción (p=0.000; rho=0.507). En resumen, se concluyó que existe una relación directa y moderada entre la calidad de atención y la satisfacción de los usuarios del servicio de referencias y contrarreferencias de un hospital en Lima en 2023

Mistranslation Drives Alterations in Protein Levels and the Effects of a Synonymous Variant at the Fibroblast Growth Factor 21 Locus

Fibroblast growth factor 21 (FGF21) is a liver-derived hormone with pleiotropic beneficial effects on metabolism. Paradoxically, FGF21 levels are elevated in metabolic diseases. Interventions that restore metabolic homeostasis reduce FGF21. Whether abnormalities in FGF21 secretion or resistance in peripheral tissues is the initiating factor in altering FGF21 levels and function in humans is unknown. A genetic approach is used to help resolve this paradox. The authors demonstrate that the primary event in dysmetabolic phenotypes is the elevation of FGF21 secretion. The latter is regulated by translational reprogramming in a genotype- and context-dependent manner. To relate the findings to tissues outcomes, the minor (A) allele of rs838133 is shown to be associated with increased hepatic inflammation in patients with metabolic associated fatty liver disease. The results here highlight a dominant role for translation of the FGF21 protein to explain variations in blood levels that is at least partially inherited. These results provide a framework for translational reprogramming of FGF21 to treat metabolic diseases.Peer reviewe

Inclusion Body Myositis: Laser Microdissection Reveals Differential Up-Regulation of IFN-γ Signaling Cascade in Attacked versus Nonattacked Myofibers

Sporadic inclusion body myositis (IBM) is a muscle disease with two separate pathogenic components, degeneration and inflammation. Typically, nonnecrotic myofibers are focally surrounded and invaded by CD8+ T cells and macrophages. Both attacked and nonattacked myofibers express high levels of human leukocyte antigen class I (HLA-I) molecules, a prerequisite for antigen presentation to CD8+ T cells. However, only a subgroup of HLA-I+ myofibers is attacked by immune cells. By using IHC, we classified myofibers from five patients with sporadic IBM as attacked (AIBM) or nonattacked (NIBM) and isolated the intracellular contents of myofibers separately by laser microdissection. For comparison, we isolated myofibers from control persons (HCTRL). The samples were analyzed by microarray hybridization and quantitative PCR. HLA-I up-regulation was observed in AIBM and NIBM, whereas HCTRL were negative for HLA-I. In contrast, the inducible chain of the interferon (IFN) γ receptor (IFNGR2) and several IFN-γ–induced genes were up-regulated in AIBM compared with NIBM and HCTRL fibers. Confocal microscopy confirmed segmental IFNGR2 up-regulation on the membranes of AIBM, which positively correlated with the number of adjacent CD8+ T cells. Thus, the differential up-regulation of the IFN-γ signaling cascade observed in the attacked fibers is related to local inflammation, whereas the ubiquitous HLA-I expression on IBM muscle fibers does not require IFNGR expression

Effective Rheology of Bubbles Moving in a Capillary Tube

We calculate the average volumetric flux versus pressure drop of bubbles moving in a single capillary tube with varying diameter, finding a square-root relation from mapping the flow equations onto that of a driven overdamped pendulum. The calculation is based on a derivation of the equation of motion of a bubble train from considering the capillary forces and the entropy production associated with the viscous flow. We also calculate the configurational probability of the positions of the bubbles.Comment: 4 pages, 1 figur