13 research outputs found
Percepci贸n de los estudiantes de los cursos de programaci贸n multimedia de la carrera de comunicaciones y signos y s铆mbolos de la carrera de dise帽o gr谩fico de la Universidad de Ciencias y Artes de Am茅rica Latina (UCAL) respecto de la aplicaci贸n de una estrategia de ense帽anza gamificada destinada al incremento de la motivaci贸n y participaci贸n en el aula
Esta investigaci贸n explora el alcance del dise帽o de una estrategia de ense帽anza elaborada empleando elementos de la gamificaci贸n con la finalidad de observar la percepci贸n que tienen los estudiantes de carreras creativas en este tipo de estrategia. Para ello se han elaborado dos estrategias de ense帽anza-aprendizaje para ser aplicadas en dos cursos de las carreras de Dise帽o Gr谩fico y Comunicaciones de la Universidad de Ciencias y Artes de Am茅rica Latina (UCAL), que tienen la particularidad de ser comunes en varias carreras. A trav茅s de esta aplicaci贸n se pudo observar en una muestra delimitada, la percepci贸n de estudiantes de Arquitectura, Arquitectura de Interiores, Dise帽o Gr谩fico Publicitario y Comunicaciones. El objetivo general es determinar cu谩l es la percepci贸n hacia la estrategia gamificada que tienen los estudiantes de los dos cursos de la Universidad de Ciencias y Artes de Am茅rica Latina que fueron seleccionados como muestra: Programaci贸n Multimedia, de la carrera de Comunicaciones y Signos y S铆mbolos de la carrera de Dise帽o Gr谩fico Publicitario. La investigaci贸n se realiz贸 dise帽ando una estrategia gamificada empleando el proceso del marco de referencia LEGA y conectando la teor铆a del Octalysis para potenciar los diferentes objetivos de los dos cursos, enfatizando: participaci贸n, motivaci贸n e interacci贸n social. Estos marcos de referencia luego dieron paso a determinar los elementos de juego que se iban a incorporar a la sesi贸n de ense帽anza aprendizaje para posteriormente elaborar el material educativo que permit铆an las condiciones de ambos cursos. Todo esto apoyado en la teor铆a del aprendizaje social de Bandura, principios de dise帽o instruccional de Lepper en motivaci贸n intr铆nseca, teor铆a del andamiaje de Bruner y la teor铆a del fluir de Mihaly Csikszentmihalyi.Trabajo de investigaci贸nCampus Lima Centr
Multiexon deletion alleles of ATF6 linked to achromatopsia
Achromatopsia (ACHM) is an autosomal recessive disease that results in severe visual loss. Symptoms of ACHM include impaired visual acuity, nystagmus, and photoaversion starting from infancy; furthermore, ACHM is associated with bilateral foveal hypoplasia and absent or severely reduced cone photoreceptor function on electroretinography. Here, we performed genetic sequencing in 3 patients from 2 families with ACHM, identifying and functionally characterizing 2 mutations in the activating transcription factor 6 (ATF6) gene. We identified a homozygous deletion covering exons 8-14 of the ATF6 gene from 2 siblings from the same family. In another patient from a different family, we identified a heterozygous deletion covering exons 2 and 3 of the ATF6 gene found in trans with a previously identified ATF6 c.970C>T (p.Arg324Cys) ACHM disease allele. Recombinant ATF6 proteins bearing these exon deletions showed markedly impaired transcriptional activity by qPCR and RNA-Seq analysis compared with WT-ATF6. Finally, RNAscope revealed that ATF6 and the related ATF6B transcripts were expressed in cones as well as in all retinal layers in normal human retina. Overall, our data identify loss-of-function ATF6 disease alleles that cause human foveal disease
Recognizing daily living activity using embedded sensors in smartphones:A data-driven approach
Smartphones are widely available commercial devices and using them as a basis to creates the possibility of future widespread usage and potential applications. This paper utilizes the embedded sensors in a smartphone to recognise a number of common human actions and postures. We group the range of all possible human actions into five basic action classes, namely walking, standing, sitting, crouching and lying. We also consider the postures pertaining to three of the above actions, including standing postures (backward, straight, forward and bend), sitting postures (lean, upright, slouch and rest) and lying postures (back, side and stomach). Training data was collected through a number of people performing a sequence of these actions and postures with a smartphone in their shirt pockets. We analysed and compared three classification algorithms, namely k Nearest Neighbour (kNN), Decision Tree Learning (DTL) and Linear Discriminant Analysis (LDA) in terms of classification accuracy and efficiency (training time as well as classification time). kNN performed the best overall compared to the other two and is believed to be the most appropriate classification algorithm to use for this task. The developed system is in the form of an Android app. Our system can real-time accesses the motion data from the three sensors and on-line classifies a particular action or posture using the kNN algorithm. It successfully recognizes the specified actions and postures with very high precision and recall values of generally above 96%
Percepci贸n de los estudiantes de los cursos de programaci贸n multimedia de la carrera de comunicaciones y signos y s铆mbolos de la carrera de dise帽o gr谩fico de la Universidad de Ciencias y Artes de Am茅rica Latina (UCAL) respecto de la aplicaci贸n de una estrategia de ense帽anza gamificada destinada al incremento de la motivaci贸n y participaci贸n en el aula
Trabado de investigacionEsta investigaci贸n explora el alcance del dise帽o de una estrategia de ense帽anza elaborada empleando elementos de la gamificaci贸n con la finalidad de observar la percepci贸n que tienen los estudiantes de carreras creativas en este tipo de estrategia. Para ello se han elaborado dos estrategias de ense帽anza-aprendizaje para ser aplicadas en dos cursos de las carreras de Dise帽o Gr谩fico y Comunicaciones de la Universidad de Ciencias y Artes de Am茅rica Latina (UCAL), que tienen la particularidad de ser comunes en varias carreras. A trav茅s de esta aplicaci贸n se pudo observar en una muestra delimitada, la percepci贸n de estudiantes de Arquitectura, Arquitectura de Interiores, Dise帽o Gr谩fico Publicitario y Comunicaciones. El objetivo general es determinar cu谩l es la percepci贸n hacia la estrategia gamificada que tienen los estudiantes de los dos cursos de la Universidad de Ciencias y Artes de Am茅rica Latina que fueron seleccionados como muestra: Programaci贸n Multimedia, de la carrera de Comunicaciones y Signos y S铆mbolos de la carrera de Dise帽o Gr谩fico Publicitario. La investigaci贸n se realiz贸 dise帽ando una estrategia gamificada empleando el proceso del marco de referencia LEGA y conectando la teor铆a del Octalysis para potenciar los diferentes objetivos de los dos cursos, enfatizando: participaci贸n, motivaci贸n e interacci贸n social. Estos marcos de referencia luego dieron paso a determinar los elementos de juego que se iban a incorporar a la sesi贸n de ense帽anza aprendizaje para posteriormente elaborar el material educativo que permit铆an las condiciones de ambos cursos. Todo esto apoyado en la teor铆a del aprendizaje social de Bandura, principios de dise帽o instruccional de Lepper en motivaci贸n intr铆nseca, teor铆a del andamiaje de Bruner y la teor铆a del fluir de Mihaly Csikszentmihalyi
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PERK-mediated induction of microRNA-483 disrupts cellular ATP homeostasis during the unfolded protein response
Endoplasmic reticulum (ER) stress activates the unfolded protein response (UPR), which reduces levels of misfolded proteins. However, if ER homeostasis is not restored and the UPR remains chronically activated, cells undergo apoptosis. The UPR regulator, PKR-like endoplasmic reticulum kinase (PERK), plays an important role in promoting cell death when persistently activated; however, the underlying mechanisms are poorly understood. Here, we profiled the microRNA (miRNA) transcriptome in human cells exposed to ER stress and identified miRNAs that are selectively induced by PERK signaling. We found that expression of a PERK-induced miRNA, miR-483, promotes apoptosis in human cells. miR-483 induction was mediated by a transcription factor downstream of PERK, activating transcription factor 4 (ATF4), but not by the CHOP transcription factor. We identified the creatine kinase brain-type (CKB) gene, encoding an enzyme that maintains cellular ATP reserves through phosphocreatine production, as being repressed during the UPR and targeted by miR-483. We found that ER stress, selective PERK activation, and CKB knockdown all decrease cellular ATP levels, leading to increased vulnerability to ER stress-induced cell death. Our findings identify miR-483 as a downstream target of the PERK branch of the UPR. We propose that disruption of cellular ATP homeostasis through miR-483-mediated CKB silencing promotes ER stress-induced apoptosis
Neurodegeneration risk factor, EIF2AK3 (PERK), influences tau protein aggregation
Tauopathies are neurodegenerative diseases caused by pathologic misfolded tau protein aggregation in the nervous system. Population studies implicate EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3), better known as PERK (protein kinase R-like endoplasmic reticulum kinase), as a genetic risk factor in several tauopathies. PERK is a key regulator of intracellular proteostatic mechanisms-unfolded protein response and integrated stress response. Previous studies found that tauopathy-associated PERK variants encoded functional hypomorphs with reduced signaling in vitro. But, it remained unclear how altered PERK activity led to tauopathy. Here, we chemically or genetically modulated PERK signaling in cell culture models of tau aggregation and found that PERK pathway activation prevented tau aggregation, whereas inhibition exacerbated tau aggregation. In primary tauopathy patient brain tissues, we found that reduced PERK signaling correlated with increased tau neuropathology. We found that tauopathy-associated PERK variants targeted the endoplasmic reticulum luminal domain; and two of these variants damaged hydrogen bond formation. Our studies support that PERK activity protects against tau aggregation and pathology. This may explain why people carrying hypomorphic PERK variants have increased risk for developing tauopathies. Finally, our studies identify small-molecule augmentation of PERK signaling as an attractive therapeutic strategy to treat tauopathies by preventing tau pathology