Melodia : A Comprehensive Course in Sight-Singing (Solfeggio)

Melodia is a 1904 book designed to teach sight-singing. The educational plan is by Samuel W. Cole; the exercises were written and selected by Leo R. Lewis. Melodia is presented here as a complete edition and has also been divided into its four separate books.https://scholarworks.sjsu.edu/oer/1000/thumbnail.jp

Role of Temperature, Dissolved Oxygen, and Backwaters in the Winter Survival of Freshwater Drum (\u3ci\u3eAplodinotus grunniens\u3c/i\u3e) in the Mississippi River

Annual winter impingement of large numbers of freshwater drum (Aplodinotus grunniens) on screens of a power station intake on the Mississippi River led to an investigation of the cause of impingement. Impingement occurred most abundantly in winter and early spring and primarily involved juvenile fish. Pronounced drift of moribund and dead fish was found in the main channel above and below the power station in late winter. Laboratory studies indicated that juvenile freshwater drum became disoriented, incapacitated, and suffered increased mortality as water temperature dropped to 1 °C and below. In winter and early spring, temperatures were 0 °C in the main and side channels of the river, but pockets of water above 1 °C existed in some backwaters. Dissolved oxygen concentrations declined through the winter, becoming very low in some backwaters. An aggregation of fishes including freshwater drum was observed in the warmer backwaters. Variations in river flow and dissolved oxygen depletion in some backwaters were postulated to cause periodic disruption of the thermal refuges and an associated appearance of incapacitated and dead juvenile freshwater drum in the drift. If man-induced changes to the river eliminate backwater winter refuges, the ichthyofauna of the river could ultimately be altered

The Violin My Great Grand-Daddy Made / music by Ernie Erdman; words by Roger Lewis

Cover: a drawing of a man playing Violin; a photo inset of Shale and Cole; Publisher: Leo Feist Inc. (New York)https://egrove.olemiss.edu/sharris_c/1077/thumbnail.jp

Cinema as mnemotechnics

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Adjuvant Statin Therapy for Esophageal Adenocarcinoma: a cost-effectiveness analysis

Background: Emerging preclinical evidence indicates statins, medications commonly used in the prevention of cardiovascular disease, inhibit proliferation, promote apoptosis and limit invasiveness of esophageal adenocarcinoma (EAC). Population-based observational data demonstrates statin treatment after diagnosis of EAC is associated with significant reductions in all-cause and cancer-specific mortality. A feasibility study of adjuvant statin therapy following potentially curative resection for EAC has completed, with planned progression to a full phase III randomised controlled trial Aim: To estimate the cost-utility of statin therapy following surgical resection for EAC from an NHS perspective. Methods: A Markov model was developed to estimate the costs and outcomes (quality adjusted life years, QALYs) for hypothetical cohorts of patients with EAC exposed or not exposed to statins following potentially curative surgical resection. Model parameters were based on estimates from published observational and trial data. Costs, utilities and transition probabilities were modelled to reflect clinical practice from a payer’s perspective. Probabilistic and one-way sensitivity analyses were performed to account for uncertainty in key parameters. Results: Overall, a cost-saving of £6,781 per patient was realised with statin treatment compared to no statins. In probabilistic sensitivity analysis, 99% of all iterations were cost-saving and 99% of all iterations were less than £20,000 per QALY gained. These results were robust to changes in the price and effectiveness of statins. Conclusions: The cohort exposed to statins had lower costs and better QALY outcomes than the no statin cohort. Assuming a causal relationship between statin exposure and outcomes suggests that statins following resection of EAC is a cost-saving treatment