2,685 research outputs found
Management of lymphoma survivor patients in Italy: an evaluation by Fondazione Italiana Linfomi
Several outpatient models for the follow-up of cancer survivors have been developed worldwide. A multidisciplinary approach is often necessary to guarantee the best monitoring of long-term toxicities. Guidelines also indicate a close education on healthy lifestyles. In this context, we have analyzed the Italian follow-up modalities of lymphoma survivors, with the aim to have a starting line to hypothesize and plan the best model for Italian hematology centers
Proteomics signature of autoimmune atrophic gastritis: towards a link with gastric cancer
Background: Autoimmune atrophic gastritis (AAG) is a chronic disease that can progress to gastric cancer (GC). To better understand AAG pathology, this proteomics study investigated gastric proteins whose expression levels are altered in this disease and also in GC.
Methods: Using two-dimensional difference gel electrophoresis (2D-DIGE), we compared protein maps of gastric corpus biopsies from AAG patients and controls. Differentially abundant spots (|fold change|≥ 1.5, P < 0.01) were selected and identified by LC-MS/MS. The spots were further assessed in gastric antrum biopsies from AAG patients (without and with Helicobacter pylori infection) and from GC patients and unaffected first-degree relatives of GC patients.
Results: 2D-DIGE identified 67 differentially abundant spots, with 28 more and 39 less abundant in AAG-corpus than controls. LC-MS/MS identified these as 53 distinct proteins. The most significant (adjusted P < 0.01) biological process associated with the less abundant proteins was "tricarboxylic acid cycle". Of the 67 spots, 57 were similarly differentially abundant in AAG-antrum biopsies irrespective of H. pylori infection status. The differential abundance was also observed in GC biopsies for 14 of 28 more abundant and 35 of 39 less abundant spots, and in normal gastric biopsies of relatives of GC patients for 6 and 25 spots, respectively. Immunoblotting confirmed the different expression levels of two more abundant proteins (PDIA3, GSTP gene products) and four less abundant proteins (ATP5F1A, PGA3, SDHB, PGC).
Conclusion: This study identified a proteomics signature of AAG. Many differential proteins were shared by GC and may be involved in the progression of AAG to GC
Performance of ALICE pixel prototypes in high energy beams
The two innermost layers of the ALICE inner tracking system are instrumented
with silicon pixel detectors. Single chip assembly prototypes of the ALICE
pixels have been tested in high energy particle beams at the CERN SPS.
Detection efficiency and spatial precision have been studied as a function of
the threshold and the track incidence angle. The experimental method, data
analysis and main results are presented.Comment: 10 pages, 9 figures, contribution to PIX2005 Workshop, Bonn
(Germany), 5-8 September 200
Production of H and H with the (K,) reaction
The production of neutron rich -hypernuclei via the
(,) reaction has been studied using data collected with the
FINUDA spectrometer at the DANE -factory (LNF). The analysis of the
inclusive momentum spectra is presented and an upper limit for the
production of H and H from Li and Li, is
assessed for the first time.Comment: 11 pages, 3 figures. Accepted for publication in PL
Beam Test Performance and Simulation of Prototypes for the ALICE Silicon Pixel Detector
The silicon pixel detector (SPD) of the ALICE experiment in preparation at
the Large Hadron Collider (LHC) at CERN is designed to provide the precise
vertex reconstruction needed for measuring heavy flavor production in heavy ion
collisions at very high energies and high multiplicity. The SPD forms the
innermost part of the Inner Tracking System (ITS) which also includes silicon
drift and silicon strip detectors. Single assembly prototypes of the ALICE SPD
have been tested at the CERN SPS using high energy proton/pion beams in 2002
and 2003. We report on the experimental determination of the spatial precision.
We also report on the first combined beam test with prototypes of the other ITS
silicon detector technologies at the CERN SPS in November 2004. The issue of
SPD simulation is briefly discussed.Comment: 4 pages, 5 figures, prepared for proceedings of 7th International
Position Sensitive Detectors Conference, Liverpool, Sept. 200
A study of the proton spectra following the capture of in Li and C with FINUDA
Momenta spectra of protons emitted following the capture of in Li
and C have been measured with 1% resolution. The C spectrum is
smooth whereas for Li a well defined peak appears at about 500 MeV/. The
first observation of a structure in this region was identified as a strange
tribaryon or, possibly, a -nuclear state. The peak is correlated with a
coming from decay in flight, selected by setting momenta
larger than 275 MeV/. The could be produced, together with a 500
MeV/ proton, by the capture of a in a deuteron-cluster substructure of
the Li nucleus. The capture rate for such a reaction is (1.62\pm
0.23_{stat} ^{+0.71}_{-0.44}(sys))%/K^-_{stop}, in agreement with the existing
observations on He targets and with the hypothesis that the Li nucleus
can be interpreted as a cluster.Comment: 21 pages, 10 figures. Accepted for publication in NP
Molecular Landscape and Association with Crohn Disease of Poorly Cohesive Carcinomas of the Nonampullary Small Bowel
Objectives: Poorly cohesive carcinomas (PCCs) are neoplasms defined by a predominantly dyshesive growth pattern with single cell or cord-like stromal infiltration. The -distinctive clinicopathologic and prognostic features of small bowel PCCs (SB-PCCs) in comparison with conventional-type small intestinal adenocarcinomas have only recently been characterized. However, as SB-PCCs' genetic profile is still unknown, we aimed to analyze the molecular landscape of SB-PCCs. Methods: A next-generation sequencing analysis through Trusight Oncology 500 on a series of 15 nonampullary SB-PCCs was performed. Results: The most frequently found gene alterations were TP53 (53%) and RHOA (13%) mutations and KRAS amplification (13%), whereas KRAS, BRAF, and PIK3CA mutations were not identified. Most SB-PCCs (80%) were associated with Crohn disease, including both RHOA-mutated SB-PCCs, which featured a non-SRC-type histology, and showed a peculiar appendiceal-type, low-grade goblet cell adenocarcinoma (GCA)-like component. Rarely, SB-PCCs showed high microsatellite instability, mutations in IDH1 and ERBB2 genes, or FGFR2 amplification (one case each), which are established or promising therapeutic targets in such aggressive cancers. Conclusions: SB-PCCs may harbor RHOA mutations, which are reminiscent of the diffuse subtype of gastric cancers or appendiceal GCAs, while KRAS and PIK3CA mutations, commonly involved in colorectal and small bowel adenocarcinomas, are not typical of such cancers
A study of the etapipi channel produced in central pp interactions at 450 GeV/c
The reaction pp -> pf (eta pi pi) ps has been studied at 450 GeV/c. There is
clear evidence for an a2(1320)pi decay mode of the eta2(1645) and eta2(1870).
In addition, there is evidence for an a0(980)pi$ decay mode of both resonances
and an f2(1270)eta decay mode of the eta2(1870). No evidence is found for a JPC
= 2++ a2(1320)pi wave.Comment: 15 pages, Latex, 4 Figures Branching ratio a2pi /f2 eta correcte
Proton spectra from Non-Mesonic Weak Decay of p-shell Lambda-Hypernuclei and evidence for the two-nucleon induced process
New spectra from the FINUDA experiment of the Non Mesonic Weak Decay (NMWD)
proton kinetic energy for 9(Lambda)Be, 11(Lambda)B, 12(Lambda)C, 13(Lambda)C,
15 (Lambda)N and 16(Lambda)O are presented and discussed along with the
published data on 5(Lambda)He and 7(Lambda)Li. Exploiting the large mass number
range and the low energy threshold (15 MeV) for the proton detection of FINUDA,
an evaluation of both Final State Interactions (FSI) and the two nucleon
induced NMWD contributions to the decay process has been done. Based on this
evaluation, a linear dependence of FSI on the hypernuclear mass number A is
found and for the two nucleon stimulated decay rate the experimental value of
Gamma2/Gammap=0.43+-0.25 is determined for the first time. A value for the two
nucleon stimulated decay rate to the total decay rate
Gamma2/GammaNMWD=0.24+-0.10 is also extracted.Comment: 11 pages and 2 figure
A study of the centrally produced baryon-antibaryon systems in pp interactions at 450 GeV/c
A study of the centrally produced ppbar, ppbarpi, ppbarpipi and lambda lambda
channels has been performed in pp collisions using an incident beam momentum of
450 GeV/c. No significant new structures are observed in the mass spectra,
however, important new information on the production dynamics is obtained. A
systematic study of the production properties of these systems has been
performed and it is found that these systems are not produced dominantly by
double Pomeron exchange.Comment: 13 pages, Latex, 4 Figure
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