The barriers and facilitators influencing the sustainability of hospital-based interventions: a systematic review

Acknowledgements University of Stirling for providing financial support for open access costs Funding This review was funded by the Chief Scientist Office, grant number GCA/17/26. JC, PC and EAD are employed by the Nursing, Midwifery and Allied Health Professions Research Unit, which is funded by the Chief Scientist Office in Scotland.Peer reviewedPublisher PD

Histone H1 Subtypes Differentially Modulate Chromatin Condensation without Preventing ATP-Dependent Remodeling by SWI/SNF or NURF

Although ubiquitously present in chromatin, the function of the linker histone subtypes is partly unknown and contradictory studies on their properties have been published. To explore whether the various H1 subtypes have a differential role in the organization and dynamics of chromatin we have incorporated all of the somatic human H1 subtypes into minichromosomes and compared their influence on nucleosome spacing, chromatin compaction and ATP-dependent remodeling. H1 subtypes exhibit different affinities for chromatin and different abilities to promote chromatin condensation, as studied with the Atomic Force Microscope. According to this criterion, H1 subtypes can be classified as weak condensers (H1.1 and H1.2), intermediate condensers (H1.3) and strong condensers (H1.0, H1.4, H1.5 and H1x). The variable C-terminal domain is required for nucleosome spacing by H1.4 and is likely responsible for the chromatin condensation properties of the various subtypes, as shown using chimeras between H1.4 and H1.2. In contrast to previous reports with isolated nucleosomes or linear nucleosomal arrays, linker histones at a ratio of one per nucleosome do not preclude remodeling of minichromosomes by yeast SWI/SNF or Drosophila NURF. We hypothesize that the linker histone subtypes are differential organizers of chromatin, rather than general repressors

A quantification of discharge readiness after outpatient anaesthesia: patients’ vs nurses’ assesment

Objectives: Criteria for discharge after outpatient surgery do not take into consideration the patients’ assessment of discharge readiness. Our aim was to compare discharge readiness as determined by nurses with that determined by patients against the modified Aldrete score as a benchmark.Design and setting: In this prospective study, a single observer followed 194 outpatients in the PACU. A modified Aldrete score was assigned and further assessments were made at 15-min intervals in parallel with those made by nursing staff. Nurses and patients were blinded to each other’s assessments . Discharge readiness was quantified according to three different approaches: 1) time to reach a modified Aldrete score of >9, 2) time to discharge readiness according to the patient’s own evaluation and, 3) time to discharge readiness according to nursing assessments.Results: All three times were significantly different from each other. a) Time to achieve a modified Aldrete score >9 was 8.3+7.6 min, b) Time the patient felt discharge ready was 45.3+39.5 min, c) Time the patient was actually discharged by nurses was 86.8+45.8 min. Conclusions: Nursing staff tend to keep patients an additional 41.5 + 36.6 min in the PACU compared to the patients’ own evaluation. Significant cost saving could be potentially realised if outpatients who achieve a modified Aldrete score >9 are allowed some freedom in the determination of their own discharge readiness

Imazalil residue loading and green mould control on citrus fruit as affected by formulation, solution pH and exposure time in aqueous dip treatments

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