Thermal Properties of Starch from Exotic-by-Adapted Corn (Zea mays L.) Lines Grown in Four Environments

The effect of four growing environments (two at Ames, IA; one at Clinton, IL; and one at Columbia, MO) on the thermal properties of starch from five exotic-by-adapted corn inbred lines (Chis37, Cuba34, Cuba38, Dk8, Dk10) and two control lines (B73 and Mo17) were studied using differential scanning calorimetry (DSC). The variations in thermal properties within environments were similar for the exotic-by-adapted lines and control lines. Missouri was the warmest environment and generally produced starch with the greatest gelatinization onset temperature (ToG), the narrowest range of gelatinization (RG), and the greatest enthalpy of gelatinization (ΔHG). Illinois was the coolest environment and generally resulted in starch with the lowest ToG, widest RG, and lowest ΔHG. These differences were attributed to higher temperatures in Missouri during grain-filling months either increasing the amount of longer branches of amylopectin or perfecting amylopectin crystalline structure. The Ames 1 environment produced starch with thermal properties most similar to those of Illinois, whereas the Ames 2 environment produced starch with thermal properties most similar to those of Missouri. Ames 2, located near a river bottom where temperatures tend to be warmer, likely had temperatures most similar to those found in Missouri during grain filling

Survey of Experiences with Sexual Aggression at Eastern Illinois University

This paper is a report on a survey of sexually aggressive experiences as self-reported by a large sample of undergraduate students attending Eastern Illinois University. The results of the paper were later used to reduce the incidence of sexual violence at the institution

A comparison of sexually assaultive, coercive, and non-aggressive college men

This study compares local prevalance rates of college male sexual aggression with those established nationally, and explores variables that may contribute to the development of sexually aggressive college men. A survey of 1682 (M = 619, W = 983) undergraduate students from a mid-sized university revealed rates similar to those found by a national study. Results of discriminant analysis indicated that sexually aggressive men were likely to have more sexual partners, to have been victims of childhood sexual and / or physical abuse, to have had their first sexual intercourse at an earlier age, and to have engaged in higher levels of voluntary intimacy with women. Results are interpreted in terms of prevailing models of male sexual aggression

A comparison of sexually assaultive, coercive, and non-aggressive college men

This study compares local prevalance rates of college male sexual aggression with those established nationally, and explores variables that may contribute to the development of sexually aggressive college men. A survey of 1682 (M = 619, W = 983) undergraduate students from a mid-sized university revealed rates similar to those found by a national study. Results of discriminant analysis indicated that sexually aggressive men were likely to have more sexual partners, to have been victims of childhood sexual and / or physical abuse, to have had their first sexual intercourse at an earlier age, and to have engaged in higher levels of voluntary intimacy with women. Results are interpreted in terms of prevailing models of male sexual aggression

Current-Induced Entanglement of Nuclear Spins in Quantum Dots

We propose an entanglement mechanism of nuclear spins in quantum dots driven by the electric current accompanied by the spin flip. This situation is relevant to a leakage current in spin-blocked regions where electrons cannot be transported unless their spins are flipped. The current gradually increases the components of larger total spin of nuclei. This correlation among the nuclear spins markedly enhances the spin-flip rate of electrons and hence the leakage current. The enhancement of the current is observable when the residence time of electrons in the quantum dots is shorter than the dephasing time T*_2 of nuclear spins.Comment: 4 pages, 4 figure

Long-term survival in people with transthyretin amyloid cardiomyopathy who took tafamidis: A Plain Language Summary

WHAT IS THIS PLAIN LANGUAGE SUMMARY ABOUT?: This summary presents the results from an ongoing, long-term extension study that followed an earlier study called ATTR-ACT. People who took part in this extension study and ATTR-ACT have a type of heart disease known as transthyretin amyloid cardiomyopathy (ATTR-CM for short), which causes heart failure and death. In ATTR-ACT, people took either a medicine called tafamidis or a placebo (a pill that looks like the study drug but does not contain any active ingredients) for up to 2½ years. So far, in the long-term extension study, people have continued taking tafamidis, or switched from taking a placebo to tafamidis, for another 2½ years. Researchers looked at how many people died in ATTR-ACT and the extension study. The long-term extension study is expected to end in 2027, so these are interim (not final) results. WHAT DID RESEARCHERS FIND OUT?: In the extension study of ATTR-ACT, the risk of dying was lower in people who took tafamidis continuously throughout ATTR-ACT and the extension study than in people who took placebo in ATTR-ACT and switched to tafamidis in the extension study. WHAT DO THE RESULTS MEAN?: Taking tafamidis increases how long people with ATTR-CM live. People with ATTR-CM who take tafamidis early and continuously are more likely to live longer than those who do not. These results highlight the importance of early detection and treatment in people with ATTR-CM. Clinical Trial Registration: NCT01994889 (ClinicalTrials.gov) Clinical Trial Registration: NCT02791230 (ClinicalTrials.gov)

Rapid Screening to Identify Unusual Thermal Starch Traits from Bulked Corn Kernels

Differential scanning calorimetry (DSC) is used routinely to screen for starch thermal properties. In early generations of line development, the established analysis separately evaluates starch extracted from five, single corn kernels. A thermal property trait carried by a recessive gene would appear 25% of the time; thus, if five separate kernels were evaluated, the likelihood of detecting an unusual thermal trait is high. The objective of the current work was to expedite selection by examining five kernels at a time, instead of one, hypothesizing that we would be able to detect different thermal properties in this blend. Corn lines, all from the same genetic background (ExSeed68 or Oh43), with known thermal functions (amylose-extender, dull, sugary-1, sugary-2, and waxy) were blended with normal starch (control) in ratios of 0:5, 1:4, 2:3, 3:2, 4:1, and 5:0, and analyzed with DSC. The values for each ratio within a mutant type were unique (α This article is from Cereal Chemistry, 2004, 81(4); 527-532. Doi: http://dx.doi.org/10.1094/CCHEM.2004.81.4.527.</p

Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group.

Cancer immunotherapy has transformed the treatment of cancer. However, increasing use of immune-based therapies, including the widely used class of agents known as immune checkpoint inhibitors, has exposed a discrete group of immune-related adverse events (irAEs). Many of these are driven by the same immunologic mechanisms responsible for the drugs\u27 therapeutic effects, namely blockade of inhibitory mechanisms that suppress the immune system and protect body tissues from an unconstrained acute or chronic immune response. Skin, gut, endocrine, lung and musculoskeletal irAEs are relatively common, whereas cardiovascular, hematologic, renal, neurologic and ophthalmologic irAEs occur much less frequently. The majority of irAEs are mild to moderate in severity; however, serious and occasionally life-threatening irAEs are reported in the literature, and treatment-related deaths occur in up to 2% of patients, varying by ICI. Immunotherapy-related irAEs typically have a delayed onset and prolonged duration compared to adverse events from chemotherapy, and effective management depends on early recognition and prompt intervention with immune suppression and/or immunomodulatory strategies. There is an urgent need for multidisciplinary guidance reflecting broad-based perspectives on how to recognize, report and manage organ-specific toxicities until evidence-based data are available to inform clinical decision-making. The Society for Immunotherapy of Cancer (SITC) established a multidisciplinary Toxicity Management Working Group, which met for a full-day workshop to develop recommendations to standardize management of irAEs. Here we present their consensus recommendations on managing toxicities associated with immune checkpoint inhibitor therapy