Search for Randall-Sundrum excitations of gravitons decaying into two photons for CMS at LHC

The CMS detector discovery potential to the resonant production of massive Kaluza - Klein excitations expected in Randall-Sundrum model is studied. Full simulation and reconstruction are used to study diphoton decay of Randall-Sundrum gravitons. For an integrated luminosity of 30 fb^-1 diphoton decay of Randall-Sundrum graviton can be discovered at 5 sigma level for masses up to 1.61~tevsucqua in case of weak coupling between graviton excitations and Standard model particles (c=0.01). Heavier resonances can be detected for larger coupling constant (c=0.1), with mass reach of 3.95~tevsucqua

Reilhac

Date de l'opération : 1990 (FP) ; 1988 (SU) Inventeur(s) : Lemaire Claude ; Séronie-Vivien Marie-Roger En 1988, suite à des travaux clandestins, Claude Lemaire effectua un sauvetage dans cette nouvelle cavité du causse de Gramat. Le tamisage et l'évacuation d'une énorme quantité de déblais lui permirent de récupérer un abondant mobilier lithique et osseux et de décrire une première succession stratigraphique. Devant l'intérêt du gisement, Jean Clottes a proposé à Marie-Roger Séronie-Vivien d'..

Reilhac – Grotte du Sanglier

Date de l'opération : 1990 (FP) ; 1988 (SU) Inventeur(s) : Lemaire Claude ; Séronie-Vivien Marie-Roger En 1988, suite à des travaux clandestins, Claude Lemaire effectua un sauvetage dans cette nouvelle cavité du causse de Gramat. Le tamisage et l'évacuation d'une énorme quantité de déblais lui permirent de récupérer un abondant mobilier lithique et osseux et de décrire une première succession stratigraphique. Devant l'intérêt du gisement, Jean Clottes a proposé à Marie-Roger Séronie-Vivien d'..

Deuteron Production in alpha-Nucleus Collisions from 200 to 800 MeV per Nucleon

peer reviewe

Identification of Hypoxia-Regulated Proteins Using MALDI-Mass Spectrometry Imaging Combined with Quantitative Proteomics

Hypoxia is present in most solid tumors and is clinically correlated with increased metastasis and poor patient survival. While studies have demonstrated the role of hypoxia and hypoxia-regulated proteins in cancer progression, no attempts have been made to identify hypoxia-regulated proteins using quantitative proteomics combined with MALDI-mass spectrometry imaging (MALDI-MSI). Here we present a comprehensive hypoxic proteome study and are the first to investigate changes in situ using tumor samples. In vitro quantitative mass spectrometry analysis of the hypoxic proteome was performed on breast cancer cells using stable isotope labeling with amino acids in cell culture (SILAC). MS analyses were performed on laser-capture microdissected samples isolated from normoxic and hypoxic regions from tumors derived from the same cells used in vitro. MALDI-MSI was used in combination to investigate hypoxia-regulated protein localization within tumor sections. Here we identified more than 100 proteins, both novel and previously reported, that were associated with hypoxia. Several proteins were localized in hypoxic regions, as identified by MALDI-MSI. Visualization and data extrapolation methods for the in vitro SILAC data were also developed, and computational mapping of MALDI-MSI data to IHC results was applied for data validation. The results and limitations of the methodologies described are discussed. 2014 American Chemical Societ

Excitation of the Delta (1232)-Resonance in Proton-Nucleus Collisions

peer reviewe

Energy Resolution Performance of the CMS Electromagnetic Calorimeter

The energy resolution performance of the CMS lead tungstate crystal electromagnetic calorimeter is presented. Measurements were made with an electron beam using a fully equipped supermodule of the calorimeter barrel. Results are given both for electrons incident on the centre of crystals and for electrons distributed uniformly over the calorimeter surface. The electron energy is reconstructed in matrices of 3 times 3 or 5 times 5 crystals centred on the crystal containing the maximum energy. Corrections for variations in the shower containment are applied in the case of uniform incidence. The resolution measured is consistent with the design goals

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Search with the CMS detector for Randall-Sundrum excitations of gravitons decaying into electron pairs

The sensitivity of the CMS experiment to the resonant production of massive Kaluza-Klein excitations of gravitons, expected in the framework of the Randall-Sundrum model, is studied. Full simulation and reconstruction are used to investigate this production followed by graviton decay to an e+e- pair. For a Randall-Sundrum model with coupling parameter c=0.01, the graviton excitations have weak couplings to Standard Model particles. For an integrated luminosity of 100 fb-1, resonances can be discovered at the 5sigma level for masses up to 1.8 TeV/c2. Heavier resonances are accessible for larger value of the c parameter, with a mass reach of 3.8 TeV/c2 for c=0.1