Compassion as a practical and evolved ethic for conservation

© The Author(s) 2015. Published by Oxford University Press on behalf of the American Institute of Biological Sciences. The ethical position underpinning decisionmaking is an important concern for conservation biologists when setting priorities for interventions. The recent debate on how best to protect nature has centered on contrasting intrinsic and aesthetic values against utilitarian and economic values, driven by an inevitable global rise in conservation conflicts. These discussions have primarily been targeted at species and ecosystems for success, without explicitly expressing concern for the intrinsic value and welfare of individual animals. In part, this is because animal welfare has historically been thought of as an impediment to conservation. However, practical implementations of conservation that provide good welfare outcomes for individuals are no longer conceptually challenging; they have become reality. This reality, included under the auspices of "compassionate conservation," reflects an evolved ethic for sharing space with nature and is a major step forward for conservation

Social science in a water observing system

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95008/1/wrcr12336.pd

Adenovirus-5-Vectored P. falciparum Vaccine Expressing CSP and AMA1. Part B: Safety, Immunogenicity and Protective Efficacy of the CSP Component

Background: A protective malaria vaccine will likely need to elicit both cell-mediated and antibody responses. As adenovirus vaccine vectors induce both these responses in humans, a Phase 1/2a clinical trial was conducted to evaluate the efficacy of an adenovirus serotype 5-vectored malaria vaccine against sporozoite challenge.\ud \ud Methodology/Principal Findings: NMRC-MV-Ad-PfC is an adenovirus vector encoding the Plasmodium falciparum 3D7 circumsporozoite protein (CSP). It is one component of a two-component vaccine NMRC-M3V-Ad-PfCA consisting of one adenovector encoding CSP and one encoding apical membrane antigen-1 (AMA1) that was evaluated for safety and immunogenicity in an earlier study (see companion paper, Sedegah et al). Fourteen Ad5 seropositive or negative adults received two doses of NMRC-MV-Ad-PfC sixteen weeks apart, at 1x1010 particle units per dose. The vaccine was safe and well tolerated. All volunteers developed positive ELISpot responses by 28 days after the first immunization (geometric mean 272 spot forming cells/million[sfc/m]) that declined during the following 16 weeks and increased after the second dose to levels that in most cases were less than the initial peak (geometric mean 119 sfc/m). CD8+ predominated over CD4+ responses, as in the first clinical trial. Antibody responses were poor and like ELISpot responses increased after the second immunization but did not exceed the initial peak. Pre-existing neutralizing antibodies (NAb) to Ad5 did not affect the immunogenicity of the first dose, but the fold increase in NAb induced by the first dose was significantly associated with poorer antibody responses after the second dose, while ELISpot responses remained unaffected. When challenged by the bite of P. falciparum-infected mosquitoes, two of 11 volunteers showed a delay in the time to patency compared to infectivity controls, but no volunteers were sterilely protected.\ud \ud Significance: The NMRC-MV-Ad-PfC vaccine expressing CSP was safe and well tolerated given as two doses, but did not provide sterile protection

The logic of informality: Pattern and process in a São Paulo favela

Informality is thought of as a spontaneous, uncontrolled response to the mass urbanization rapidly sweeping the globe. Much of the new housing stock in the developing world is being provided for by the informal sector. Rather than treat this as an unplanned, liminal spatial practice, we should instead seek to better theorize and describe its socio-spatial logic. We propose that informal settlements do exhibit a complex logic that is grounded in practice, which we refer to as a logic of enactment. We develop a set of propositions for characterizing these logics, building on a Bourdieusian framework, and test these in Guapira II, a favela in São Paulo. Informal logic, as manifested in informal settlements, is seen to exhibit the characteristics of sociopoiesis and contextuality, constituting a complex rationality. The nature of design in the informal is a relational one

Optimizing the layout and design of branched pipeline water distribution systems

Branched distribution systems are found in a large number of situations, including rural irrigation, reclaimed water distribution, and effluent disposal. Much research has been developed around optimizing pipeline design assuming a predetermined geographical layout of the distribution system. There has been less work done, however, on the problem of optimizing the configuration of the network itself, which is a particularly crucial issue in lower-income areas where the need for cost-effective irrigation systems is greatest. Generally, engineers develop the basic layout through experience and sheer intuition. In this paper, a method is developed for determining an optimal layout for a branched distribution system given only the spatial distribution of potential customers and their respective demands. The technique utilizes a mixed integer linear programming (MILP) algorithm to optimize an empirically derived objective function. The method is tailored for practical application and allows the decision maker to simultaneously solve for the optimal customer/user base and pipeline layout. The method is illustrated with a simple example. © Springer Science + Business Media, Inc. 2006.link_to_subscribed_fulltex