Mathematical Model of Friction Coefficient Determination for Lubricated Surfaces

This article reviews mathematical model for the determination of friction coefficient for lubricated surfaces which operate works at sliding friction pairs in boundary lubrication case. In the particular model an absolutely smooth ball and rough surface contact is viewed taking into account properties of the material, surface roughness parameters, lubricating material kinematic viscosity and density. The model refers to widely spread ball-on-disc type tribometer where ball is in the contacts with plane

The Influence of the Technological Process on the Surface Quality and Tribological Properties of Powder Details

Nowadays the materials made by methods of powder metallurgy are widely used for producing details of the heavy-duty friction pair. Due to high reliability and effective combination of mechanical and tribological properties such materials are usually used in transport industry, for example for gear assemblies of different kinds of automobiles, brake system of high speed trains, aircrafts etc. There are many variations of powder materials, but for friction pairs the iron based antifriction materials, for example Fe-C-Cu, Fe-P, Fe-Cu-Sn, Fe-Cu-Sn-Pb-MoS2, Fe-C-Cu-Ni-Mo and others are successfully used. In recent years, the requirements for antifriction materials are raised highly because of more intensive freight traffic and speed of vehicles. On the other hand, the demand of more inexpensive materials and effective using of natural resources is the issue of the day.The aim of this paper is to offer the new low-cost metal powder material based on Fe-C compound with content of Ni and Mo up to 0.3%. The influence of the parameters of technological process (pressing and sintering) on physical properties (porosity, density), mechanical properties (hardness) as well as on 2D roughness and 3D texture parameters was studied and is presented in this paper as well. The “Taylor Hobson Ltd” 3D measurement system has been used in metrological study. The analysis of the influence of the technological process on the surface roughness parameters is given. The tribological properties (friction coefficient) were evaluated using “ball-on-disk” testing without lubrication. The analysis of achieved results is prove the appropriateness of using of new low-alloy metal powder material on the iron base for producing details of friction pair. One of the possible applications - bushes for braking systems of railway rolling stock. Using offered material allows reducing the product cost in complex with acceptable wear resistance and durability

Tribological and Mechanical Properties of the Nanostructured Superlattice Coatings with Respect to Surface Texture

This research is funded by the Latvian Council of Science, project “Carbon-rich self-healing multifunctional nanostructured smart coatings (NSC) for high-tech applications using high-power confined plasma technology for their deposition”, project No. 2019/1-0385.Ceramic Nanostructured Superlattice Coatings (NSC) have broad applicability to improve the parts’ and assemblies’ tribological and mechanical properties for the needs of the automotive and aerospace industries. Improving the material properties using nanocoatings for such a widely used material as, for example, bearing steel 100Cr6 makes it possible to improve the service life of machine parts. In this paper, the correlation dependence between tribological and mechanical properties of the NSC and its surface texture are considered to determine how much surface texture will affect the tribological performance of the coated workpieces, as well as the measuring and evaluation procedure of the nanocoatings, are presented. Three different NSC described by a general empirical formula {TiMe1Me2-CN/TiAlSi-N}n and based on the modified carbonitride/nitride non-stoichiometric chemical composition were created, and their tribological and mechanical properties measured and analyzed in the context with surface texture. NSC deposited by the advanced PVD (Physical vapor deposition) technique demonstrated significantly higher wear resistance (up to 28 times), reasonably lower friction coefficient (CoF) (up to 4 times), and significantly higher hardness of the coated workpieces (up to 7 times) versus substrate material. A strong correlation between the steady-state dry sliding friction, CoF, and the amplitude and functional surface texture parameters of tribo-track were observed. The first results of the initiated research regarding the correlation analysis of the tribological and mechanical properties, on the one hand, and surface texture, on the other hand, of the NSC are reported here. © 2022 by the authors.Latvian Council of Science project No. 2019/1-0385; Institute of Solid-State Physics, University of Latvia has received funding from the European Union's Horizon 2020 Framework Programme H2020-WIDESPREAD-01-2016-2017-Teaming Phase 2 under grant agreement No. 739508, project CAMART2

Tribological and Micromechanical Properties of the Nanostructured Carbonitride/Nitride Coatings of Transition Metals Alloyed by Hf and Nb

This research was funded by the Latvian Council of Science, project “Carbon-rich self-healing multifunctional nanostructured smart coatings (NSC) for high-tech applications using high-power confined plasma technology for their deposition”, project No. 2019/1-0385.In this article, the fabrication, characterization, tribological performance, and micromechanical properties of nanostructured smart coatings (NSC) based on the multilayered alternating carbonitride/nitride bilayer {TiMe-CN/TiAlSi-N}n system are discussed. The symbol “Me” denotes refractory metals Hf or Nb, and the index “n” shows the number of superlattice periods. The NSC samples were deposited onto bearing steel (100Cr6) substrates using a reactive high-power physical vapor deposition (PVD) technique that can be scaled up for industrial use. The deposited multilayered NSC contained crystalline nanometer-scale TiMe-CN/TiAlSi-N nanoparticles strengthened by Hf or Nb additives, which increased surface microhardness up to 3000 HV. The measured steady-state friction coefficient (CoF) was within the 0.2–0.4 range, and a specific wear rate lower than 2 × 10−6 mm3/Nm was observed in the dry friction regime. The impact of NSC substrate hardness and NSC coating thickness on microhardness measurement values was investigated. A thicker coating provided a higher integrated (coating + substrate) microhardness value at a lower indentation test force (<0.3 N). As the indentation test force increased, the obtained microhardness values decreased faster for the coatings deposited on a softer substrate. The surface roughness impact on wear properties for specific NSC coatings was observed. --//-- This is an open-access article Leitans, A.; Jansons, E.; Lungevics, J.; Kundzins, K.; Boiko, I.; Kanders, U.; Kovalenko, V.; Linins, O. Tribological and Micromechanical Properties of the Nanostructured Carbonitride/Nitride Coatings of Transition Metals Alloyed by Hf and Nb. Coatings 2023, 13, 552. https://doi.org/10.3390/coatings13030552 published under the CC BY 4.0 licence.This research was funded by the Latvian Council of Science, project “Carbon-rich self-healing multifunctional nanostructured smart coatings (NSC) for high-tech applications using high-power confined plasma technology for their deposition”, project No. 2019/1-0385. The Institute of Solid State Physics, University of Latvia at the Center of Excellence has received funding from the European Union’s Horizon 2020 Framework Programme H2020-WIDESPREAD-01-2016-2017-TeamingPhase2 under grant agreement No. 739508, project CAMART2

3H-1,2-benzoxathiepine 2,2-dioxides: a new class of isoform-selective carbonic anhydrase inhibitors

A new chemotype with carbonic anhydrase (CA, EC 4.2.1.1) inhibitory action has been discovered, the homo-sulfocoumarins (3H-1,2-benzoxathiepine 2,2-dioxides) which have been designed considering the (sulfo)coumarins as lead molecules. An original synthetic strategy of a panel of such derivatives led to compounds with a unique inhibitory profile and very high selectivity for the inhibition of the tumour associated (CA IX/XII) over the cytosolic (CA I/II) isoforms. Although the CA inhibition mechanism with these new compounds is unknown for the moment, we hypothesize that it may be similar to that of the sulfocoumarins, i.e. hydrolysis to the corresponding sulfonic acids which thereafter anchor to the zinc-coordinated water molecule within the enzyme active site

Extending the Inhibition Profiles of Coumarin-Based Compounds Against Human Carbonic Anhydrases: Synthesis, Biological, and In Silico Evaluation

Carbonic anhydrases (CAs, EC 4.2.1.1) catalyze the fundamental reaction of CO2 hydration in all living organisms and are actively involved in the regulation of a plethora of pathological and physiological conditions. A set of new coumarin/ dihydrocoumarin derivatives was here synthesized, characterized, and tested as human CA inhibitors. Their inhibitory activity was evaluated against the cytosolic human isoforms hCA I and II and the transmembrane hCA IX and hCA XII. Two compounds showed potent inhibitory activity against hCA IX, being more active or equipotent with the reference drug acetazolamide. Computational procedures were used to investigate the binding mode of this class of compounds within the active site of hCA IX and XII that are validated as anti-tumor targets

Isoform-Selective Enzyme Inhibitors by Exploring Pocket Size According to the Lock-and-Key Principle

In the design of high-affinity and enzyme isoform-selective inhibitors, we applied an approach of augmenting the substituents attached to the benzenesulfonamide scaffold in three ways, namely, substitutions at the 3,5- or 2,4,6-positions or expansion of the condensed ring system. The increased size of the substituents determined the spatial limitations of the active sites of the 12 catalytically active human carbonic anhydrase (CA) isoforms until no binding was observed because of the inability of the compounds to fit in the active site. This approach led to the discovery of high-affinity and high-selectivity compounds for the anticancer target CA IX and antiobesity target CA VB. The x-ray crystallographic structures of compounds bound to CA IX showed the positions of the bound compounds, whereas computational modeling confirmed that steric clashes prevent the binding of these compounds to other isoforms and thus avoid undesired side effects. Such an approach, based on the Lock-and-Key principle, could be used for the development of enzyme-specific drug candidate compounds

Efficient Expression and Crystallization System of Cancer-Associated Carbonic Anhydrase Isoform IX

Human carbonic anhydrase IX (CA IX) is overexpressed in a number of solid tumors and is considered to be a marker for cellular hypoxia that it is not produced in most normal tissues. CA IX contributes to the acidification of the extracellular matrix, which, in turn, favors tumor growth and metastasis. Therefore, CA IX is considered to be a promising anti-cancer drug target. However, the ability to specifically target CA IX is challenging due to the fact that the human genome encodes 15 different carbonic anhydrase isoforms that have a high degree of homology. Furthermore, structure-based drug design of CA IX inhibitors so far has been largely unsuccessful due to technical difficulties regarding the expression and crystallization of the enzyme. Currently, only one baculovirus-produced CA IX structure in complex with a nonspecific CA inhibitor, acetazolamide, is available in Protein Data Bank. We have developed an efficient system for the production of the catalytic domain of CA IX in methylotrophic yeast Pichia pastoris. The produced protein can be easily crystallized in the presence of inhibitors, as we have demonstrated for several 2-thiophene-sulfonamide compounds. We have also observed significant differences in the binding mode of chemically identical compounds to CA IX and CA II, which can be further exploited in the design of CA IX-specific inhibitor