237 research outputs found
Vers une réforme des pouvoirs de la police en Angleterre
The author discusses certain reforms to the law of police powers which are currently being demanded by the English police. He notes that the English police have long acted under a regime of limited powers. These have proven to be irksome, but they have also conduced to a regime under which the police use the minimum powers possible and rely considerably on public support in the fight against crime. The police however urge that further powers are necessary, notably powers to stop and question persons in public places and to hold arrested persons for interrogation concerning the commission of offences before charging the person or bringing him before a magistrate. These wide powers resemble those of certain other systems, notably France, the practical workings of which are comparatively little known in Britain. They are of doubtful legality in view of the European Convention on Human Rights. The author questions the necessity for and the desirability of such powers. He contends that they are apt to be abused, and that the French experience affords a guide to what might happen. He argues that formal powers are no substitute for public support. He fears that powers to stop and search will cause resentment, and that little countervailing practical benefit will result from them. As regards powers to detain persons before charging, he argues that such procedures will erode existing civil liberties safeguards and that certain proposed safeguards such as limiting the time available to the police for detention will prove ineffectual. There will be little time to inform defence lawyers of the nature of the case at an early stage and magistrates will probably support the police. If detention is to be allowed judicial permission should, as a general rule, be sought in advance from a High Court Judge. Here he advances a model based upon the experience of Cyprus. The author also considers, briefly, the modalities of interrogation. He considers that the suspect must continue to have a right to silence. He must also have the right to the timely assistance of a defence lawyer, a right which presently is too often subverted by the practice. The author considers also that thought should be given to the question whether a suspect should have the right to the assistance of a lawyer during police interrogation. The author concludes that in assessing the nature of and necessity for accretions and additions to police powers, the English should not lose sight of their historic attachment to civil liberties
The Multiple Origin of Blue Straggler Stars: Theory vs. Observations
In this chapter we review the various suggested channels for the formation
and evolution of blue straggler stars (BSSs) in different environments and
their observational predictions. These include mass transfer during binary
stellar evolution - case A/B/C and D (wind Roche-lobe overflow) mass transfer,
stellar collisions during single and binary encounters in dense stellar
cluster, and coupled dynamical and stellar evolution of triple systems. We also
explore the importance of the BSS and binary dynamics in stellar clusters. We
review the various observed properties of BSSs in different environments (halo
and bulge BSSs, BSSs in globular clusters and BSSs in old open clusters), and
compare the current observations with the theoretical predictions for BSS
formation. We try to constrain the likely progenitors and processes that play a
role in the formation of BSSs and their evolution. We find that multiple
channels of BSS formation are likely to take part in producing the observed
BSSs, and we point out the strengths and weaknesses of each the formation
channel in respect to the observational constraints. Finally we point out
directions to further explore the origin of BSS, and highlight eclipsing binary
BSSs as important observational tool.Comment: Chapter 11, in Ecology of Blue Straggler Stars, H.M.J. Boffin, G.
Carraro & G. Beccari (Eds), Astrophysics and Space Science Library, Springe
Facial onset sensory and motor neuronopathy: new cases, cognitive changes and pathophysiology
Purpose of review To improve our clinical understanding of facial onset sensory and motor neuronopathy (FOSMN).
Recent findings We identified 29 new cases and 71 literature cases, resulting in a cohort of 100 patients with FOSMN. During follow-up, cognitive and behavioral changes became apparent in 8 patients, suggesting that changes within the spectrum of frontotemporal dementia (FTD) are a part of the natural history of FOSMN. Another new finding was chorea, seen in 6 cases. Despite reports of autoantibodies, there is no consistent evidence to suggest an autoimmune pathogenesis. Four of 6 autopsies had TAR DNA-binding protein (TDP) 43 pathology. Seven cases had genetic mutations associated with neurodegenerative diseases.
Summary FOSMN is a rare disease with a highly characteristic onset and pattern of disease progression involving initial sensory disturbances, followed by bulbar weakness with a cranial to caudal spread of pathology. Although not conclusive, the balance of evidence suggests that FOSMN is most likely to be a TDP-43 proteinopathy within the amyotrophic lateral sclerosis–FTD spectrum
Critical design considerations for time-to-event endpoints in amyotrophic lateral sclerosis clinical trials
Background: Funding and resources for low prevalent neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) are limited, and optimising their use is vital for efficient drug development. In this study, we review the design assumptions for pivotal ALS clinical trials with time-to-event endpoints and provide optimised settings for future trials.
Methods: We extracted design settings from 13 completed placebo-controlled trials. Optimal assumptions were estimated using parametric survival models in individual participant data (n=4991). Designs were compared in terms of sample size, trial duration, drug use and costs.
Results: Previous trials overestimated the hazard rate by 18.9% (95% CI 3.4% to 34.5%, p=0.021). The median expected HR was 0.56 (range 0.33–0.66). Additionally, we found evidence for an increasing mean hazard rate over time (Weibull shape parameter of 2.03, 95% CI 1.93 to 2.15, p<0.001), which affects the design and planning of future clinical trials. Incorporating accrual time and assuming an increasing hazard rate at the design stage reduced sample size by 33.2% (95% CI 27.9 to 39.4), trial duration by 17.4% (95% CI 11.6 to 23.3), drug use by 14.3% (95% CI 9.6 to 19.0) and follow-up costs by 21.2% (95% CI 15.6 to 26.8).
Conclusions: Implementing distributional knowledge and incorporating accrual at the design stage could achieve large gains in the efficiency of ALS clinical trials with time-to-event endpoints. We provide an open-source platform that helps investigators to make more accurate sample size calculations and optimise the use of their available resources
Blue Straggler Stars in Globular Clusters: a powerful tool to probe the internal dynamical evolution of stellar systems
This chapter presents an overview of the main observational results obtained
to date about Blue Straggler Stars (BSSs) in Galactic Globular Clusters (GCs).
The BSS specific frequency, radial distribution, chemical composition and
rotational properties are presented and discussed in the framework of using
this stellar population as probe of GC internal dynamics. In particular, the
shape of the BSS radial distribution has been found to be a powerful tracer of
the dynamical age of stellar systems, thus allowing the definition of the first
empirical "dynamical clock".Comment: Chapter 5, in Ecology of Blue Straggler Stars, H.M.J. Boffin, G.
Carraro & G. Beccari (Eds), Astrophysics and Space Science Library, Springe
The Blue Stragglers of the Old Open Cluster NGC 188
The old (7 Gyr) open cluster NGC 188 has yielded a wealth of astrophysical
insight into its rich blue straggler population. Specifically, the NGC 188 blue
stragglers are characterized by: A binary frequency of 80% for orbital periods
less than days;Typical orbital periods around 1000 days;Typical
secondary star masses of 0.5 M; At least some white dwarf companion
stars; Modestly rapid rotation; A bimodal radial spatial distribution;
Dynamical masses greater than standard stellar evolution masses (based on
short-period binaries); Under-luminosity for dynamical masses (short-period
binaries). Extensive -body modeling of NGC 188 with empirical initial
conditions reproduces the properties of the cluster, and in particular the
main-sequence solar-type binary population. The current models also reproduce
well the binary orbital properties of the blue stragglers, but fall well short
of producing the observed number of blue stragglers. This deficit could be
resolved by reducing the frequency of common-envelope evolution during Roche
lobe overflow. Both the observations and the -body models strongly indicate
that the long-period blue-straggler binaries - which dominate the NGC 188 blue
straggler population - are formed by asymptotic-giant (primarily) and red-giant
mass transfer onto main sequence stars. The models suggest that the few
non-velocity-variable blue stragglers formed from mergers or collisions.
Several remarkable short-period double-lined binaries point to the importance
of subsequent dynamical exchange encounters, and provide at least one example
of a likely collisional origin for a blue straggler.Comment: Chapter 3, in Ecology of Blue Straggler Stars, H.M.J. Boffin, G.
Carraro & G. Beccari (Eds), Astrophysics and Space Science Library, Springe
Work-Unit Absenteeism: Effects of Satisfaction, Commitment, Labor Market Conditions, and Time
Prior research is limited in explaining absenteeism at the unit level and over time. We developed and tested a model of unit-level absenteeism using five waves of data collected over six years from 115 work units in a large state agency. Unit-level job satisfaction, organizational commitment, and local unemployment were modeled as time-varying predictors of absenteeism. Shared satisfaction and commitment interacted in predicting absenteeism but were not related to the rate of change in absenteeism over time. Unit-level satisfaction and commitment were more strongly related to absenteeism when units were located in areas with plentiful job alternatives
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