Accelerometer measurements to characterize drag profiles in the mesosphere

This project will verify the capabilities of an accelerometer for launch aboard suborbitalvehicles. If our prototype reliably produces data with ample resolution, it can be used to study the mesosphere and the reentry of suborbital vehicles. With partial support from NASA\u27s Low Cost Access to Space Program, we hope to provide drag data on free-falling vehicles in the mesosphere. Our set up consists of a 3-axis accelerometer in a 10 cm CubeSat and a 12 bit data logger at 1024 Hz sampling rate. With zero-g environment data, we apply spectral analysis to find the amplitude of each frequency in our signal. In our testing phase this will be used to characterize noise present in the device while in a rocket test this will tell us how drag on the vehicle affects the rocket\u27s flight. Once we are satisfied with the behavior of the instrument and understand the voltage outputs adequately, we plan to prepare a report to XCOR Aerospace to fly our instrument on the Lynx suborbital space plane

Treatment of signs and symptoms of the common cold using EPs 7630 - results of a meta-analysis

© 2019 The Author(s) The efficacy of Pelargonium sidoides preparation EPs 7630 in the common cold (CC) was assessed by performing meta-analyses of randomized, double-blind, placebo-controlled trials. Mean differences (MD) and risk ratios (RR) with their 95% confidence intervals (CI) were computed. Five trials with a total of 833 patients were included. All trials had a treatment period of ten days with visits at days 3, 5, and 10 after baseline and used a ten-symptom Cold Intensity Score (CIS) as the primary outcome. Significant differences favoring EPs 7630 were observed for total CIS reduction (day 5: MD = -2·30; 95%CI = -4·12,-0·49; day 10: MD = -1·16; 95%CI = -2·22,-0·10), proportion of patients with substantial improvement (day 5: RR = 1·73; day 10: RR = 1·06) and complete remission (day 5: RR = 2·52; day 10: RR = 2·13). Subjects treated with EPs 7630 missed fewer days at work, used less paracetamol and had an improved sleep quality. No serious adverse reactions to EPs 7630 were reported. The results support the efficacy of EPs 7630 in adults with CC

Estimates of vertical eddy diffusivity in the upper mesosphere in the presence of a mesospheric inversion layer

Rayleigh and resonance lidar observations were made during the Turbopause experiment at Poker Flat Research Range, Chatanika Alaska (65° N, 147° W) over a 10 h period on the night of 17–18 February 2009. The lidar observations revealed the presence of a strong mesospheric inversion layer (MIL) at 74 km that formed during the observations and was present for over 6 h. The MIL had a maximum temperature of 251 K, amplitude of 27 ± 7 K, a depth of 3.0 km, and overlying lapse rate of 9.4 ± 0.3 K km−1. The MIL was located at the lower edge of the mesospheric sodium layer. During this coincidence the lower edge of the sodium layer was lowered by 2 km to 74 km and the bottomside scale height of the sodium increased from 1 km to 15 km. The structure of the MIL and sodium are analyzed in terms of vertical diffusive transport. The analysis yields a lower bound for the eddy diffusion coefficient of 430 m2 s−1 and the energy dissipation rate of 2.2 mW kg−1 at 76–77 km. This value of the eddy diffusion coefficient, determined from naturally occurring variations in mesospheric temperatures and the sodium layer, is significantly larger than those reported for mean winter values in the Arctic but similar to individual values reported in regions of convective instability by other techniques

Hard Habits to Break: Investigating Coastal Resource Utilisations and Management Systems in Sulawesi, Indonesia.

This research investigates the paradox that many coastal communities in developing countries are resource rich but income poor. Another aspect of this paradox is the belief that local communities possess traditional knowledge that respects nature. This belief contrasts the fact that major tropical coastal ecosystems, namely coral reefs and mangroves, are being destroyed at rapid and increasing rates, in many cases by the people whose livelihoods depend on them. These paradoxical circumstances lead to a central question: if the sustainability of coastal resources is vital for the livelihood of local communities, why are these resources being degraded, often to the point of complete destruction? This study explores the motives and consequences of destructive methods of coastal resource utilisation and examines the potential for sustainable livelihoods based on coastal resources currently under threat from destructive use patterns. The analysis is based on a field study conducted in 2006 and 2008 in eleven sites around the island of Sulawesi, Indonesia. This area is characterised by great biodiversity, including one of the highest marine biodiversities in the Asia-Pacific region. Coral and mangrove ecosystem resource use was found to be driven by different processes and activities; hence the destructive practices impacting both ecosystems were also different. Blast and poison fishing were the most widespread destructive resource use methods found for coral reefs whereas large-scale habitat conversion was responsible for mangrove ecosystem reduction. In the field both resources were found to be under enormous anthropogenic pressures, with published data suggesting that only 5.8% of Indonesian coral reefs are currently in excellent condition and only 38% of mangrove cover remaining in Sulawesi relative to that of 25 years ago. The dynamics of these coastal resources, and of their destruction, are classic examples of the ’tragedy of the commons’. Research findings further indicate that formal institutions tasked with managing these resources have not been able to promote their effective conservation. An array of competing demands and conflicting interests, coupled with inefficient institutional arrangements and under-investment, have rendered inadequate many resource management efforts, including the externally-imposed concepts, allowing destructive patterns of resource utilization to persist. Local communities are disempowered when confronted with (1) the intricate network of destructive-fishing actors targeting coral reefs, or (2) large company-government bureaucracy collusions allowing mangrove conversion. The existence of this collusive network must be considered in any effort to address problems of effective management. Empirical insights suggest that conservation at local level has to face the challenges of market-driven resource extraction at a global scale. Only when a coastal community manages to overcome the dilemma in managing common-pool resource, conservation measures can be implemented and a degree of sustainability attained. Findings from this research have important implications for the discourses on coastal resource policy and research. This research advances the discussions to the area where the core of conflict of interests among stakeholders took place, and yet has rarely been addressed previously. The synthesis from this study provides a strong basis to understand the nature of asymmetric relations amongst the resource stakeholders, and therefore will help in generating effective policies for a fairer coastal resource management regime

On the short-term variability of turbulence and temperature in the winter mesosphere

Four mesosphere–lower thermosphere temperature and turbulence profiles were obtained in situ within  ∼ 30&thinsp;min and over an area of about 100 by 100&thinsp;km during a sounding rocket experiment conducted on 26 January 2015 at Poker Flat Research Range in Alaska. In this paper we examine the spatial and temporal variability of mesospheric turbulence in relationship to the static stability of the background atmosphere. Using active payload attitude control, neutral density fluctuations, a tracer for turbulence, were observed with very little interference from the payload spin motion, and with high precision ( &lt; 0.01 %) at sub-meter resolution. The large-scale vertical temperature structure was very consistent between the four soundings. The mesosphere was almost isothermal, which means more stratified, between 60 and 80&thinsp;km, and again between 88 and 95&thinsp;km. The stratified regions adjoined quasi-adiabatic regions assumed to be well mixed. Additional evidence of vertical transport and convective activity comes from sodium densities and trimethyl aluminum trail development, respectively, which were both observed simultaneously with the in situ measurements. We found considerable kilometer-scale temperature variability with amplitudes of 20&thinsp;K in the stratified region below 80&thinsp;km. Several thin turbulent layers were embedded in this region, differing in width and altitude for each profile. Energy dissipation rates varied between 0.1 and 10&thinsp;mW&thinsp;kg−1, which is typical for the winter mesosphere. Very little turbulence was observed above 82&thinsp;km, consistent with very weak small-scale gravity wave activity in the upper mesosphere during the launch night. On the other hand, above the cold and prominent mesopause at 102&thinsp;km, large temperature excursions of +40 to +70&thinsp;K were observed. Simultaneous wind measurements revealed extreme wind shears near 108&thinsp;km, and combined with the observed temperature gradient, isolated regions of unstable Richardson numbers (0 &lt; Ri &lt; 0.25) were detected in the lower thermosphere. The experiment was launched into a bright auroral arc under moderately disturbed conditions (Kp ∼ 5).</p

Permutation criteria to evaluate multiple clinical endpoints in a proof-of-concept study: lessons from Pre-RELAX-AHF

Clinically relevant endpoints cannot be routinely targeted with reasonable power in a small study. Hence, proof-of-concept studies are often powered to a primary surrogate endpoint. However, in acute heart failure (AHF) effects on surrogates have not translated into clinical benefit in confirmatory studies. Although observing an effect on one of many endpoints due to chance is likely, observing concurrent positive trends across several outcomes by chance is usually unlikely. Pre-RELAX-AHF, which compared 4 relaxin doses with placebo in AHF, has shown favourable trends versus placebo (one-sided P <0.10) on six of nine clinical endpoints in the 30 mu g/kg/day group. To illustrate evaluation of multiple, correlated clinical endpoints for evidence of efficacy and for dose selection, a permutation method was applied retrospectively. By randomly re-assigning the treatment group to the actual data for each of the 229 subjects, 20,000 permutation samples were constructed. The permutation P value for at least six favourable trends among nine endpoints in any dose groups was 0.0073 (99.9% CI 0.0053-0.0093). This is higher than would be expected if the endpoints were uncorrelated (0.00026), but much lower than the probability of observing one of nine comparisons significant at the traditional two-sided P <0.05 (0.74). Thus, the result was unlikely due to correlated endpoints or to chance. Examining consistency of effect across multiple clinical endpoints in a proof-of-concept study may identify efficacious therapies and enable dose selection for confirmatory trials. The merit of the approach described requires confirmation through prospective application in designing future studies

Hunt for new phenomena using large jet multiplicities and missing transverse momentum with ATLAS in 4.7 fb−1 of s√=7TeV proton-proton collisions

Results are presented of a search for new particles decaying to large numbers of jets in association with missing transverse momentum, using 4.7 fb−1 of pp collision data at s√=7TeV collected by the ATLAS experiment at the Large Hadron Collider in 2011. The event selection requires missing transverse momentum, no isolated electrons or muons, and from ≥6 to ≥9 jets. No evidence is found for physics beyond the Standard Model. The results are interpreted in the context of a MSUGRA/CMSSM supersymmetric model, where, for large universal scalar mass m 0, gluino masses smaller than 840 GeV are excluded at the 95% confidence level, extending previously published limits. Within a simplified model containing only a gluino octet and a neutralino, gluino masses smaller than 870 GeV are similarly excluded for neutralino masses below 100 GeV

Measurements of Higgs boson production and couplings in diboson final states with the ATLAS detector at the LHC

Measurements are presented of production properties and couplings of the recently discovered Higgs boson using the decays into boson pairs, H →γ γ, H → Z Z∗ →4l and H →W W∗ →lνlν. The results are based on the complete pp collision data sample recorded by the ATLAS experiment at the CERN Large Hadron Collider at centre-of-mass energies of √s = 7 TeV and √s = 8 TeV, corresponding to an integrated luminosity of about 25 fb−1. Evidence for Higgs boson production through vector-boson fusion is reported. Results of combined fits probing Higgs boson couplings to fermions and bosons, as well as anomalous contributions to loop-induced production and decay modes, are presented. All measurements are consistent with expectations for the Standard Model Higgs boson

Standalone vertex finding in the ATLAS muon spectrometer

A dedicated reconstruction algorithm to find decay vertices in the ATLAS muon spectrometer is presented. The algorithm searches the region just upstream of or inside the muon spectrometer volume for multi-particle vertices that originate from the decay of particles with long decay paths. The performance of the algorithm is evaluated using both a sample of simulated Higgs boson events, in which the Higgs boson decays to long-lived neutral particles that in turn decay to bbar b final states, and pp collision data at √s = 7 TeV collected with the ATLAS detector at the LHC during 2011

Single hadron response measurement and calorimeter jet energy scale uncertainty with the ATLAS detector at the LHC

The uncertainty on the calorimeter energy response to jets of particles is derived for the ATLAS experiment at the Large Hadron Collider (LHC). First, the calorimeter response to single isolated charged hadrons is measured and compared to the Monte Carlo simulation using proton-proton collisions at centre-of-mass energies of sqrt(s) = 900 GeV and 7 TeV collected during 2009 and 2010. Then, using the decay of K_s and Lambda particles, the calorimeter response to specific types of particles (positively and negatively charged pions, protons, and anti-protons) is measured and compared to the Monte Carlo predictions. Finally, the jet energy scale uncertainty is determined by propagating the response uncertainty for single charged and neutral particles to jets. The response uncertainty is 2-5% for central isolated hadrons and 1-3% for the final calorimeter jet energy scale.Comment: 24 pages plus author list (36 pages total), 23 figures, 1 table, submitted to European Physical Journal