IMPLEMENTATION OF TAGUCHI APPROACH FOR PTIMIZATION OF ABRASIVE WATER JET MACHINING PROCESS PARAMETERS

In this paper, Taguchi method is applied to find optimum process parameter for Abrasive water jet machining (AWJM). Abrasive water jet machining is a non–traditional process of removal of material by impact erosion of high pressure, high velocity of water and entrained high velocity of grit abrasives on a work piece. Experimental investigation were conducted to assess the influence of abrasive water jet machining (AWJM) process parameters on MRR and surface Roughness (Ra) of aluminium. The approach was based on Taguchi’s method and analysis of variance (ANOVA) to optimize the AWJM process parameter for effective machining and to predict the optimal choice for each AWJM parameter such as pressure, standoff distance, Abrasive flow rate and Traverse rate. For each combination of orthogonal array we have conducted three experiments and with the help of ANOVA it is found that these parameters have a significant influence on machining characteristics such as metal removal rate (MRR) and surface roughness (SR). The analysis of the Taguchi method reveals that, in general the standoff distance significantly affects the MRR while, Abrasive flow rate affects the surface Roughness. Experiments are carried out using (L9) orthogonal array by varying pressure, st

A Review of Particle Swarm Optimization: Feature Selection, Classification and Hybridizations

Particle swarm optimization (PSO) is a recently grown, popular, evolutionary and conceptually simple but efficient algorithm which belongs to swarm intelligence category. This paper outlines basic concepts and reviews PSO based techniques with their applications to classification and feature selection along with some of the hybridized applications of PSO with similar other techniques. DOI: 10.17762/ijritcc2321-8169.16041

Bromo-butyl Rubber for Face Piece of a Respiratory Mask

Respiratory mask contains a number of components made of materials like rubber, plastics, and metals. Out of all the components, face piece is the main component exposed to the external environment. This study aims to evaluate degradation of bromo-butyl rubber. The experiments were carried out for thermal exposure, swelling study, saline exposure, etc. It is observed that the elongation at break was increased by 10 per cent when these were exposed to 100 oC. However, the tensile strength has been observed to decrease by 50 per cent when exposed to 55 oC. It is decreased to around 63 per cent when exposed to 80 oC and 100 oC. The morphological appearance of unaged sample was intact. Only samples at 120 oC aged for 48 h appeared to have developed minor cracks of <0.01 µm. There were no significant changes observed when the samples were exposed to saline (3 % NaCl) and artificial sweat solution.Defence Science Journal, 2009, 59(5), pp.505-511, DOI:http://dx.doi.org/10.14429/dsj.59.155

Mechanical Testing of Hybrid LM30 Metal Matrix Composite Fabricated through Stir Casting Route

Metal Matrix Composites (MMCs) are one of the strongest contenders for the application that demands excellentmechanical and physical properties. Aluminium Metal Matrix Composites (Al MMCs) are reinforced materials with improvedmechanical and physical properties as compared to the base material. Composite material made through the stir casting processpossesses higher elastic modulus, wear resistance, strength, and fatigue resistance. In the present research work, LM30 alloy ischosen as a matrix material and is reinforced with Zircon Dioxide (ZrO2), Rice Husk Ash (RHA), and Tungsten Carbide (W.C.).A stir casting setup is used to fabricate the three different composites. Composite A, Composite B, and Composite C have thecomposition of (LM30/5%WC/5%ZrO2/10%RSH), (LM30/10%WC/5%ZrO2/5RSH), (LM30/5%WC/10%ZrO2-/5% RHA),respectively. Further, mechanical testing, which includes tensile, compressive, hardness, and Charpy impact tests, has beenconducted. It has been found that Composite B possesses the highest hardness, maximum tensile, and compressive strengthamong all three composite materials

Additive Manufacturing: The Significant role in Biomedical and Aerospace applications

Additive Manufacturing (AM) is an innovative approach to manufacturing, which has proved itself way too efficient and opening a new era for complex designs and lattice structures. AM is a bottom-up manufacturing process that builds parts by stacking one layer over another. It is often called 3D printing which directly prints the object via material addition instead of subtraction in conventional manufacturing methods. It has shown a tangible approach to mass customization and unhindered options to create a complex design part. It has proved itself in many industries like the biomedical industry, aerospace industry, manufacturing firms, and academic research purposes. This article has reviewed the advancement of AM in the aerospace and biomedical industry. 3D printing technology has been incorporated in the biomedical industry to produce customized design features and implants for specific applications and performance. Implants effect like corrosion and carcinogenic properties have been discussed in the human body. This paper also discussed the design flexibility of AM with the topological study of a specific part to reduce the weight for system efficiency in the aerospace industry.

Additive manufacturing: The significant role in biomedical and aerospace applications

330-342Additive Manufacturing (AM) is an innovative approach to manufacturing, which has proved itself way too efficient and opening a new era for complex designs and lattice structures. AM is a bottom-up manufacturing process that builds parts by stacking one layer over another. It is often called 3D printing which directly prints the object via material addition instead of subtraction in conventional manufacturing methods. It has shown a tangible approach to mass customization and unhindered options to create a complex design part. It has proved itself in many industries like the biomedical industry, aerospace industry, manufacturing firms, and academic research purposes. This article has reviewed the advancement of AM in the aerospace and biomedical industry. 3D printing technology has been incorporated in the biomedical industry to produce customized design features and implants for specific applications and performance. Implants effect like corrosion and carcinogenic properties have been discussed in the human body. This paper also discussed the design flexibility of AM with the topological study of a specific part to reduce the weight for system efficiency in the aerospace industry

First-in-man application of a novel therapeutic cancer vaccine formulation with the capacity to induce multi-functional T cell responses in ovarian, breast and prostate cancer patients

BACKGROUND: DepoVax(TM) is a novel non-emulsion depot-forming vaccine platform with the capacity to significantly enhance the immunogenicity of peptide cancer antigens. Naturally processed HLA-A2 restricted peptides presented by breast, ovarian and prostate cancer cells were used as antigens to create a therapeutic cancer vaccine, DPX-0907. METHODS: A phase I clinical study was designed to examine the safety and immune activating potential of DPX-0907 in advanced stage breast, ovarian and prostate cancer patients. A total of 23 late stage cancer patients were recruited and were divided into two dose/volume cohorts in a three immunization protocol. RESULTS: DPX-0907 was shown to be safe with injection site reactions being the most commonly reported adverse event. All breast cancer patients (3/3), most of ovarian (5/6) and one third of prostate (3/9) cancer patients exhibited detectable immune responses, resulting in a 61% immunological response rate. Immune responses were generally observed in patients with better disease control after their last prior treatment. Antigen-specific responses were detected in 73% of immune responders (44% of evaluable patients) after the first vaccination. In 83% of immune responders (50% of evaluable patients), peptide-specific T cell responses were detected at ≥2 time points post vaccination with 64% of the responders (39% of evaluable patients) showing evidence of immune persistence. Immune monitoring also demonstrated the generation of antigen-specific T cell memory with the ability to secrete multiple Type 1 cytokines. CONCLUSIONS: The novel DepoVax formulation promotes multifunctional effector memory responses to peptide-based tumor associated antigens. The data supports the capacity of DPX-0907 to elicit Type-1 biased immune responses, warranting further clinical development of the vaccine. This study underscores the importance of applying vaccines in clinical settings in which patients are more likely to be immune competent. TRIAL REGISTRATION: ClinicalTrials.gov NCT0109584

Payment and Settlement System in India

The lecture is about the payment system in India, which is an important element of the financial sector infrastructure. The lecture also shows the evolution and objectives of the Indian payment system – as a public good, various milestones crossed by us in the past few decades, the major initiatives that the RBI has taken to upgrade and modernise the payment system in India to benchmark it with the best in the world, and the various technological developments that can be leveraged to further deepen the penetration of the payment system services in the country to promote greater financial inclusion. [Special Address delivered by Shri V Leeladhar, Deputy Governor, Reserve Bank of India at the Conclave on Indian Banking – Vision 2010, organised by the Indian Banks’ Association, Mumbai].settlement, history, clearing house regulations, retail, banking, electronic, RBI, system, payment, technological, devlopments, RBI, India, financial sector, infrastructure, inclusion, services, settlement,