Non-equilibrium steady state phases of the interacting Aubry-Andre-Harper model

Here we study the phase diagram of the Aubry-Andre-Harper model in the presence of strong interactions as the strength of the quasiperiodic potential is varied. Previous work has established the existence of many-body localized phase at large potential strength; here, we find a rich phase diagram in the delocalized regime characterized by spin transport and unusual correlations. We calculate the non-equilibrium steady states of a boundary-driven strongly interacting Aubry-Andre-Harper model by employing the time-evolving block decimation algorithm on matrix product density operators. From these steady states, we extract spin transport as a function of system size and quasiperiodic potential strength. This data shows spin transport going from superdiffusive to subdiffusive well before the localization transition; comparing to previous results, we also find that the transport transition is distinct from a transition observed in the speed of operator growth in the model. We also investigate the correlation structure of the steady state and find an unusual oscillation pattern for intermediate values of the potential strength. The unusual spin transport and quantum correlation structure suggest multiple dynamical phases between the much-studied thermal and many-body-localized phases.Comment: 5+2 pages, 7+3 figure

Analytical Study on the Performance Characteristics of a Liquid Injection Refrigeration Cycle.

A residential heat pump faced with reliability problems due to high compressor discharge temperature and lower performance at lower ambient temperatures. Many researchers have been trying to overcome this problem by applying vapor injection techniques. However, the application of the vapor injection cycle caused higher cost due to the increased components such as internal heat exchanger or flash tank. Liquid injection technique has merits of cost and cycle reliability due to refrigerant that discharged from the condenser was expanded and injected directly into the compressor. In this study, a simulation program for a liquid injection heat pump cycle was developed. The performance of the cycle was simulated using a mass and energy balances. The model was validated by comparing the predictions with measured data at various operating conditions. Based on the simulation results, cycle performance characteristics were discussed at various operating and compressor design conditions using the simulation program

植物の栄養分配に関わる輸送体の構造機能解析

学位の種別: 課程博士審査委員会委員 : （主査）東京大学教授 寺島 一郎, 東京大学教授 豊島 近, 東京大学教授 濡木 理, 東京大学教授 伏信 進矢, 東京大学准教授 永田 宏次University of Tokyo(東京大学

植物の栄養分配に関わる輸送体の構造機能解析

学位の種別: 課程博士審査委員会委員 : （主査）東京大学教授 寺島 一郎, 東京大学教授 豊島 近, 東京大学教授 濡木 理, 東京大学教授 伏信 進矢, 東京大学准教授 永田 宏次University of Tokyo(東京大学

Ion transfer mechanisms in Mrp-type antiporters from high resolution cryoEM and molecular dynamics simulations

Multiple resistance and pH adaptation (Mrp) cation/proton antiporters are essential for growth of a variety of halophilic and alkaliphilic bacteria under stress conditions. Mrp-type antiporters are closely related to the membrane domain of respiratory complex I. We determined the structure of the Mrp antiporter from Bacillus pseudofirmus by electron cryo-microscopy at 2.2 angstrom resolution. The structure resolves more than 99% of the sidechains of the seven membrane subunits MrpA to MrpG plus 360 water molecules, including similar to 70 in putative ion translocation pathways. Molecular dynamics simulations based on the high-resolution structure revealed details of the antiport mechanism. We find that switching the position of a histidine residue between three hydrated pathways in the MrpA subunit is critical for proton transfer that drives gated trans-membrane sodium translocation. Several lines of evidence indicate that the same histidine-switch mechanism operates in respiratory complex I.Peer reviewe

Entosis Controls a Developmental Cell Clearance in C. elegans.

Metazoan cell death mechanisms are diverse and include numerous non-apoptotic programs. One program called entosis involves the invasion of live cells into their neighbors and is known to occur in cancers. Here, we identify a developmental function for entosis: to clear the male-specific linker cell in C. elegans. The linker cell leads migration to shape the gonad and is removed to facilitate fusion of the gonad to the cloaca. We find that the linker cell is cleared in a manner involving cell-cell adhesions and cell-autonomous control of uptake through linker cell actin. Linker cell entosis generates a lobe structure that is deposited at the site of gonad-to-cloaca fusion and is removed during mating. Inhibition of lobe scission inhibits linker cell death, demonstrating that the linker cell invades its host while alive. Our findings demonstrate a developmental function for entosis: to eliminate a migrating cell and facilitate gonad-to-cloaca fusion, which is required for fertility

ISLES 2016 and 2017-Benchmarking ischemic stroke lesion outcome prediction based on multispectral MRI

Performance of models highly depend not only on the used algorithm but also the data set it was applied to. This makes the comparison of newly developed tools to previously published approaches difficult. Either researchers need to implement others' algorithms first, to establish an adequate benchmark on their data, or a direct comparison of new and old techniques is infeasible. The Ischemic Stroke Lesion Segmentation (ISLES) challenge, which has ran now consecutively for 3 years, aims to address this problem of comparability. ISLES 2016 and 2017 focused on lesion outcome prediction after ischemic stroke: By providing a uniformly pre-processed data set, researchers from all over the world could apply their algorithm directly. A total of nine teams participated in ISLES 2015, and 15 teams participated in ISLES 2016. Their performance was evaluated in a fair and transparent way to identify the state-of-the-art among all submissions. Top ranked teams almost always employed deep learning tools, which were predominately convolutional neural networks (CNNs). Despite the great efforts, lesion outcome prediction persists challenging. The annotated data set remains publicly available and new approaches can be compared directly via the online evaluation system, serving as a continuing benchmark (www.isles-challenge.org).Fundacao para a Ciencia e Tecnologia (FCT), Portugal (scholarship number PD/BD/113968/2015). FCT with the UID/EEA/04436/2013, by FEDER funds through COMPETE 2020, POCI-01-0145-FEDER-006941. NIH Blueprint for Neuroscience Research (T90DA022759/R90DA023427) and the National Institute of Biomedical Imaging and Bioengineering (NIBIB) of the National Institutes of Health under award number 5T32EB1680. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. PAC-PRECISE-LISBOA-01-0145-FEDER-016394. FEDER-POR Lisboa 2020-Programa Operacional Regional de Lisboa PORTUGAL 2020 and Fundacao para a Ciencia e a Tecnologia. GPU computing resources provided by the MGH and BWH Center for Clinical Data Science Graduate School for Computing in Medicine and Life Sciences funded by Germany's Excellence Initiative [DFG GSC 235/2]. National Research National Research Foundation of Korea (NRF) MSIT, NRF-2016R1C1B1012002, MSIT, No. 2014R1A4A1007895, NRF-2017R1A2B4008956 Swiss National Science Foundation-DACH 320030L_163363

Time-resolved serial femtosecond crystallography reveals early structural changes in channelrhodopsin

X線自由電子レーザーを用いて、光照射によるチャネルロドプシンの構造変化の過程を捉えることに成功. 京都大学プレスリリース. 2021-03-26.Channelrhodopsins (ChRs) are microbial light-gated ion channels utilized in optogenetics to control neural activity with light . Light absorption causes retinal chromophore isomerization and subsequent protein conformational changes visualized as optically distinguished intermediates, coupled with channel opening and closing. However, the detailed molecular events underlying channel gating remain unknown. We performed time-resolved serial femtosecond crystallographic analyses of ChR by using an X-ray free electron laser, which revealed conformational changes following photoactivation. The isomerized retinal adopts a twisted conformation and shifts toward the putative internal proton donor residues, consequently inducing an outward shift of TM3, as well as a local deformation in TM7. These early conformational changes in the pore-forming helices should be the triggers that lead to opening of the ion conducting pore