Investigation of the SH3BP2 Gene Mutation in Cherubism

Cherubism is a rare developmental lesion of the jaw that is generally inherited as an autosomal dominant trait. Recent studies have revealed point mutations in the SH3BP2 gene in cherubism patients. In this study, we examined a 6-year-old Korean boy and his family. We found a Pro418Arg mutation in the SH3BP2 gene of the patient and his mother. A father and his 30-month-old younger brother had no mutations. Immunohistochemically, the multinucleated giant cells proved positive for CD68 and tartrate-resistant acid phosphatase (TRAP). Numerous spindle-shaped stromal cells expressed a ligand for receptor activator of nuclear factor kB (RANKL), but not in multinucleated giant cells. These results provide evidence that RANKL plays a critical role in the differentiation of osteoclast precursor cells to multinucleated giant cells in cherubism. Additionally, genetic analysis may be a useful method for differentiation of cherubism.</p

Highly efficient source for frequency-entangled photon pairs generated in a 3rd order periodically poled MgO-doped stoichiometric LiTaO3 crystal

We present a highly efficient source for discrete frequency-entangled photon pairs based on spontaneous parametric down-conversion using 3rd order type-0 quasi-phase matching in a periodically poled MgO-doped stoichiometric LiTaO3 crystal pumped by a 355.66 nm laser. Correlated two-photon states were generated with automatic conservation of energy and momentum in two given spatial modes. These states have a wide spectral range, even under small variations in crystal temperature, which consequently results in higher discreteness. Frequency entanglement was confirmed by measuring two-photon quantum interference fringes without any spectral filtering.Comment: 4 pages, 4 figures, to be published in Optics Letter

Worst-case User Analysis in Poisson Voronoi Cells

In this letter, we focus on the performance of a worst-case mobile user (MU) in the downlink cellular network. We derive the coverage probability and the spectral efficiency of the worst-case MU using stochastic geometry. Through analytical and numerical results, we draw out interesting insights that the coverage probability and the spectral efficiency of the worst-case MU decrease down to 23% and 19% of those of a typical MU, respectively. By applying a coordinated scheduling (CS) scheme, we also investigate how much the performance of the worst-case MU is improved.Comment: Accepted, IEEE Communications Letter

Test Platform Development of Vessel???s Power Management System Using Hardware- in-the-Loop-Simulation Technique

A PMS (Power Management System) controls vessel&apos;s power systems to improve the system efficiency and to protect a blackout condition. The PMS should be developed with considering the type and the capacity of the vessel???s power system. It is necessary to test the PMS functions developed for vessel???s safe operations under various sailing situations. Therefore, the function tests in cooperation with practical power systems are required in the PMS development. In this paper, a hardware-in-the-loop (HIL) simulator is developed for the purposes of the PMS function tests. The HIL simulator can be more cost-effective, more time-saved, easier to reproduce, and safer beyond the normal operating range than conventional off-line simulators, especially at early stages in development processes or during fault tests. Vessel&apos;s power system model is developed by using a MATLAB/SIMULINK software and by communicating between an OPAL-RT???s OP5600 simulator. The PMS uses a Modbus communication protocol implemented using LabVIEW software. Representative tests of the PMS functions are performed to verify the validity of the proposed HIL-based test platform

High energy-charged cell factory for heterologous protein synthesis

Overexpression of gluconeogenic phosphoenolpyruvate carboxykinase (PCK) under glycolytic conditions enables Escherichia coli to maintain a greater intracellular ATP concentration and, consequently, to up-regulate genes for amino acid and nucleotide biosynthesis. To investigate the effect of a high intracellular ATP concentration on heterologous protein synthesis, we studied the expression of a foreign gene product, enhanced green fluorescence protein (eGFP), under control of the T7 promoter in E. coli BL21(DE3) strain overexpressing PCK. This strain was able to maintain twice as much intracellular ATP and to express two times more foreign protein than the control strain. These results indicate that a high energy-charged cell can be beneficial as a protein-synthesizing cell factory. The potential uses of such a cell factory are discussed