817 research outputs found

    Application of the collocation method using hermite cubic splines to nonlinear transient one-dimensional heat-conduction problems

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    This report addresses the application of the collocation method using hermite cubic splines to nonlinear transient one-dimensional heat conduction problems

    The substance of cultural evolution: Culturally framed systems of social organization

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    Models of cultural evolution need to address not only the organizational aspects of human societies, but also the complexity and structure of cultural idea systems that frame their systems of organization. These cultural idea systems determine a framework within which behaviors take place and provide mutually understood meanings for behavior from the perspective of both agent and recipient that are critical for the coherence of human systems of social organization

    Schwinger, Pegg and Barnett approaches and a relationship between angular and Cartesian quantum descriptions II: Phase Spaces

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    Following the discussion -- in state space language -- presented in a preceding paper, we work on the passage from the phase space description of a degree of freedom described by a finite number of states (without classical counterpart) to one described by an infinite (and continuously labeled) number of states. With that it is possible to relate an original Schwinger idea to the Pegg and Barnett approach to the phase problem. In phase space language, this discussion shows that one can obtain the Weyl-Wigner formalism, for both Cartesian {\em and} angular coordinates, as limiting elements of the discrete phase space formalism.Comment: Subm. to J. Phys A: Math and Gen. 7 pages, sequel of quant-ph/0108031 (which is to appear on J.Phys A: Math and Gen

    Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet

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    Vascular calcification is common in chronic kidney disease, where cardiovascular mortality remains the leading cause of death. Patients with kidney disease are often prescribed vitamin D receptor agonists (VDRAs) that confer a survival benefit, but the underlying mechanisms remain unclear. Here we tested two VDRAs in a mouse chronic kidney disease model where dietary phosphate loading induced aortic medial calcification. Mice were given intraperitoneal calcitriol or paricalcitol three times per week for 3 weeks. These treatments were associated with half of the aortic calcification compared to no therapy, and there was no difference between the two agents. In the setting of a high-phosphate diet, serum parathyroid hormone and calcium levels were not significantly altered by treatment. VDRA therapy was associated with increased serum and urine klotho levels, increased phosphaturia, correction of hyperphosphatemia, and lowering of serum fibroblast growth factor-23. There was no effect on elastin remodeling or inflammation; however, the expression of the anticalcification factor, osteopontin, in aortic medial cells was increased. Paricalcitol upregulated osteopontin secretion from mouse vascular smooth muscle cells in culture. Thus, klotho and osteopontin were upregulated by VDRA therapy in chronic kidney disease, independent of changes in serum parathyroid hormone and calcium

    The limit of N=(2,2) superconformal minimal models

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    The limit of families of two-dimensional conformal field theories has recently attracted attention in the context of AdS/CFT dualities. In our work we analyse the limit of N=(2,2) superconformal minimal models when the central charge approaches c=3. The limiting theory is a non-rational N=(2,2) superconformal theory, in which there is a continuum of chiral primary fields. We determine the spectrum of the theory, the three-point functions on the sphere, and the disc one-point functions.Comment: 37 pages, 3 figures; v2: minor corrections in section 5.3, version to be published in JHE
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