Membrane fluidity and temperature sensing are coupled via circuitry comprised of Ole1, Rsp5, and Hsf1 in Candida albicans

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Surviving the heat of the moment : a fungal pathogens perspective

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Posttranslational modifications of proteins in the pathobiology of medically relevant fungi

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Energy efficient engine: Turbine intermediate case and low-pressure turbine component test hardware detailed design report

A four stage, low pressure turbine component has been designed to power the fan and low pressure compressor system in the Energy Efficient Engine. Designs for a turbine intermediate case and an exit guide vane assembly also have been established. The components incorporate numerous technology features to enhance efficiency, durability, and performance retention. These designs reflect a positive step towards improving engine fuel efficiency on a component level. The aerodynamic and thermal/mechanical designs of the intermediate case and low pressure turbine components are presented and described. An overview of the predicted performance of the various component designs is given

Material Flow Analysis: Outcome Focus (MFA:OF) for Elucidating the Role of Infrastructure in the Development of a Liveable City

Engineered infrastructures (i.e., utilities, transport & digital) underpin modern society. Delivering services via these is especially challenging in cities where differing infrastructures form a web of interdependencies. There must be a step change in how infrastructures deliver services to cities, if those cities are to be liveable in the future (i.e., provide for citizen wellbeing, produce less CO2 & ensure the security of the resources they use). Material Flow Analysis (MFA) is a useful methodology for understanding how infrastructures transfer resources to, within and from cities and contribute to the city’s metabolism. Liveable Cities, a five-year research programme was established to identify & test radical engineering interventions leading to liveable cities of the future. In this paper, the authors propose an outcome-focussed variation on the MFA methodology (MFA: OF), evidenced through work on the resource flows of Birmingham, UK. These flows include water, energy, food & carbon-intensive materials (e.g., steel, paper, glass), as well as their associated waste. The contribution MFA: OF makes to elucidating the interactions & interdependencies between the flows is highlighted and suggestions are made for how it can contribute to the (radical) rethinking of the engineered infrastructure associated with such flow

Dear Wife : the Civil War letters of Chester K. Leach

Occasional paper (University of Vermont. Center for Research on Vermont) ; no. 20

A polyphonic acoustic vortex and its complementary chords

Using an annular phased array of eight loudspeakers, we generate sound beams that simultaneously contain phase singularities at a number of different frequencies. These frequencies correspond to different musical notes and the singularities can be set to overlap along the beam axis, creating a polyphonic acoustic vortex. Perturbing the drive amplitudes of the speakers means that the singularities no longer overlap, each note being nulled at a slightly different lateral position, where the volume of the other notes is now nonzero. The remaining notes form a tri-note chord. We contrast this acoustic phenomenon to the optical case where the perturbation of a white light vortex leads to a spectral spatial distribution

Modelling the regulation of thermal adaptation in Candida albicans, a major fungal pathogen of humans

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