The Role and Value of Chaplains in an Australian Ambulance Service: A Comparative Study of Chaplain and Paramedic Perspectives

Chaplains are embedded in several ambulance services across Australia, however as Australia’s religiosity is currently in decline and questions are being asked about retaining chaplains, little is actually known about their role and value within Ambulance services. The aim of this paper is to present the key findings from interviews with chaplains about their role and value of being ambulance chaplains. These findings are then compared with those of paramedics derived from an earlier phase of this study. Thirteen chaplains participated in semi-structured interviews, and data were analysed using framework analysis. The results indicated that ambulance chaplains provided paramedic-centred emotional and spiritual care through proactively and reactively supporting paramedics in their work. Chaplains saw value in their relational approach which facilitated trust and access, did not seek to ‘fix’ or diagnose but instead offered physical and emotional presence, and promoted supportive conversations. Chaplains and paramedics valued operationally trained and equipped ambulance chaplains who provided a relational, around the clock, ‘frontline’ staff support presence in paramedic workplaces, regardless of the paramedic’s personal religious/spiritual beliefs

Direct syntheses of stereoisomers of 3-fluoro GABA and β-fluoroamine analogues of the calcium receptor (CaR) agonists, cinacalcet, tecalcet, fendilines and NPS R-467

Synthetic routes following a sequential MacMillan organocatalytic asymmetric α-fluorination protocol for aldehydes and then reductive amination, have allowed ready access to bioactive β-fluoroamines. The approach is demonstrated with a short synthesis of (S)-3-fluoro-γ-aminobutyric acid (3F-GABA) and was extended to β-fluoroamine stereoisomers of cinacalcet, tecalcet, fendiline and NPS R-467, all allosteric modulators of the calcium receptor (CaR). Stereoisomers of the fluorinated calcimimetic analogues were then assayed in a CaR receptor assay and a comparison of β-fluoroamine matched pair stereoisomers revealed a binding mode preference to the receptor as deduced from conformations which will be favoured as a consequence of the electrostatic gauche effect.Publisher PDFPeer reviewe

Roles of intraloops-2 and -3 and the proximal C-terminus in signalling pathway selection from the human calcium-sensing receptor

AbstractThe calcium-sensing receptor (CaSR) couples to signalling pathways via intracellular loops 2 and 3, and the C-terminus. However, the requirements for signalling are largely undefined. We investigated the impacts of selected point mutations in iL-2 (F706A) and iL-3 (L797A and E803A), and a truncation of the C-terminus (R866X) on extracellular Ca2+ (Ca2+o)-stimulated phosphatidylinositol-specific phospholipase-C (PI-PLC) and various other signalling responses. CaSR-mediated activation of PI-PLC was markedly attenuated in all four mutants and similar suppressions were observed for Ca2+o-stimulated ERK1/2 phosphorylation. Ca2+o-stimulated intracellular Ca2+ (Ca2+i) mobilization, however, was relatively preserved for the iL-2 and iL-3 mutants and suppression of adenylyl cyclase was unaffected by either E803A or R866X. The CaSR selects for specific signalling pathways via the proximal C-terminus and key residues in iL-2, iL-3

The impact of a low traffic neighbourhood intervention on urban noise measured with low-cost sensors in Oxford, UK

Noise pollution, particularly in urban environments, is often caused by road traffic and is linked to increased risk of a range of adverse health outcomes. In recent years, Low Traffic Neighbourhoods (LTN) have been implemented in a number of UK towns and cities as an intervention to reduce road traffic and improve health and wellbeing among those living in residential areas. In this study, eight low-cost acoustic sensors (AudioMoth) were used to evaluate the effect of a LTN intervention on urban noise in a residential area of Oxford, UK. The acoustic energy and LAeq of the noise is evaluated before and after the introduction of the LTN at locations where traffic filters have been erected, other locations in the LTN, possible displacement locations, and a control location. In addition, source apportionment (anthropogenic or biotic) is undertaken using the Normalised Difference Soundscape Index (NDSI) using the frequency of the measured noise. The results show that in terms of acoustic energy almost all locations experienced a reduction in noise after the introduction of the LTN. In terms of the source apportionment, all locations except for the control location experienced more biotic noise after the introduction of the LTN. The results are also compared to other more traffic focussed locations in Oxford and the soundscape is much more biotic inside the LTN. Overall, the study demonstrates the impact of the LTN on urban noise, and the efficacy of this new sensing and analytical approach for evaluating noise pollution interventions

Niche overlap of mountain hare subspecies and the vulnerability of their ranges to invasion by the European hare; the (bad) luck of the Irish

Niche conservatism is the tendency of related species to retain ancestral tolerances after geographic separation. We used Ecological Niche Modelling and Principal Components Analysis of bioclimatic and habitat variables to describe the extent of the species niche, and degrees of bioclimatic\u2013habitat niche conservatism within the mountain hare (L. timidus) clade. Mountain hare niche space was contrasted with that of the European hare (L. europaeus), to shed light on species interactions in contact zones throughout Europe. All five subspecies of mountain hare had quantifiably distinct niches. Fennoscandian (L.t. sylvaticus, L.t. timidus) and highland (L.t. scoticus, L.t. varronis) subspecies, however, were most similar, exhibiting greatest apparent niche conservatism. They inhabit tundra, boreal forest and uplands, and, hence are presumed most similar to the ancestral form. The Irish hare was distinct, being consistently distinguished from other mountain hares in both 2D and nth dimensional (4D) niche space. The ecological distinctiveness of the Irish hare provides further evidence that it is an Evolutionarily Significant Unit, particularly vulnerable to displacement by introduced European hares with which it competes and hybridises. Projections under global climate change suggest that, by 2070, bioclimatic space for invasive European hares in Ireland will expand (by 79%) but contract for endemic Irish hares (by 75%), further facilitating their replacement. The near complete species replacement of the heath hare (L.t. sylvaticus) in southern Sweden, where the European hare has also been introduced, may suggest a similar fate may be in store for the Irish hare

Environmental enrichment induces optimistic cognitive bias in rats

People’s affective or emotional state can alter their cognitive processing, biasing interpretation of ambiguous stimuli. Those in a more positive state interpret such stimuli in a more optimistic manner than those in a negative state. Recently this research has extended to animals, and has shown that manipulations associated with negative affect cause animals to interpret ambiguous stimuli more pessimistically. We investigated whether exposure to environmental enrichment engenders optimistic responses to ambiguous stimuli. Rats, Rattus norvegicus, were trained on a novel conditional discrimination task whereby they learned the correct response necessary to obtain a food reward given the stimulus present during approach (rough or smooth sandpaper). One stimulus was associated with a higher-value reward than the other. Once the rats were trained, cognitive bias was probed by exploring their responses to an ambiguous stimulus (intermediate grade of sandpaper); a rat was defined as optimistic if it chose the response appropriate to the stimulus associated with the better reward. Animals transferred from unenriched to enriched cages showed more optimistic responses following the change. A control group maintained in unenriched cages showed pessimistic responses throughout. These results demonstrate for the first time that environmental enrichment can induce an optimistic cognitive bias in rats previously housed in standard caging, possibly indicative of a more positive affective state. These results add support to the suggestion that measuring cognitive biases can give an insight into animal emotional states; this has implications for animal welfare and preclinical testing of potential therapeutics for mood disorders

Can video improve grant review quality and lead to more reliable ranking?

Multimedia video is rapidly becoming mainstream, and many studies indicate that it is a more effective communication medium than text. In this project we AIM to test if videos can be used, in place of text-based grant proposals, to improve communication and increase the reliability of grant ranking. We will test if video improves reviewer comprehension (AIM 1), if external reviewer grant scores are more consistent with video (AIM 2), and if mock Australian Research Council (ARC) panels award more consistent scores when grants are presented as videos (AIM 3). This will be the first study to evaluate the use of video in this application. The ARC reviewed over 3500 Discovery Project applications in 2015, awarding 635 Projects. Selecting the “best” projects is extremely challenging. This project will improve the selection process by facilitating the transition from text-based to video-based proposals. The impact could be profound: Improved video communication should streamline the grant preparation and review processes, enable more reliable ranking of applications, and more accurate identification of the “next big innovations”