Regional circulation patterns of Mediterranean Outflow Water near the Iberian and African continental slopes

The Mediterranean Outflow Water (MOW) is a dense water mass originated in the Strait of Gibraltar. Downstream of the Gulf of Cádiz, the MOW forms a reservoir region west of the Iberian continental slopes at a buoyant depth of approximately 1000&thinsp;m. This region plays a key role as the main centre where the MOW is mixed and distributed into the North Atlantic. The seafloor in this area is characterized by the presence of a complex bathymetry with three abyssal plains separated by mountain chains. Although the topographic features do not reach the surface, they influence ocean flows at intermediate and deep ocean layers, conditioning the distribution and circulation of MOW. The Copernicus Marine Environmental Monitoring Service (CMEMS) Iberian–Biscay–Ireland (IBI) ocean reanalysis is used to provide a detailed view of the circulation and mixing processes of MOW near the Iberian and African continental slopes. This work emphasizes the relevance of the complex bathymetric features defining the circulation processes of MOW in this region. The high resolution of the IBI reanalysis allows us to make a description of the mesoscale features forced by the topography. The temperature, salinity, velocity, transport, and vorticity fields are analysed to understand the circulation patterns of MOW. The high-resolution circulation patterns reveal that Horseshoe Basin and the continental slope near Cape Ghir (a.k.a. Cap Rhir or Cabo de Aguer) are key areas controlling the mixing processes of MOW with the surrounding water masses, mainly North Atlantic Central Water (NACW) and Antarctic Intermediate Water (AAIW). The water mass variability is also analysed by means of composite analysis. Results indicate the existence of a variability in the MOW tongue which retracts and expands westwards in opposition to the movement of the underlying North Atlantic Deep Water.</p

Protection of Sinorhizobium against Host Cysteine-Rich Antimicrobial Peptides Is Critical for Symbiosis

A bacterial membrane protein, BacA, protects Sinorhizobium meliloti against the antimicrobial activity of host peptides, enabling the peptides to induce bacterial persistence rather than bacterial death

Copernicus Marine Service Ocean State Report

This is the final version. Available from Taylor & Francis via the DOI in this record

Copernicus Marine Service ocean state report, issue 4

This is the final version. Available from Taylor & Francis via the DOI in this record. FCT/MCTE

Correction: Socio-economic position as a moderator of cardiometabolic outcomes in patients receiving psychotropic treatment associated with weight gain: results from a prospective 12-month inception cohort study and a large population-based cohort.

Weight gain and metabolic complications are major adverse effects of many psychotropic drugs. We aimed to understand how socio-economic status (SES), defined as the Swiss socio-economic position (SSEP), is associated with cardiometabolic parameters after initiation of psychotropic medications known to induce weight gain. Cardiometabolic parameters were collected in two Swiss cohorts following the prescription of psychotropic medications. The SSEP integrated neighborhood-based income, education, occupation, and housing condition. The results were then validated in an independent replication sample (UKBiobank), using educational attainment (EA) as a proxy for SES. Adult patients with a low SSEP had a higher risk of developing metabolic syndrome over one year versus patients with a high SSEP (Hazard ratio (95% CI) = 3.1 (1.5–6.5), n = 366). During the first 6 months of follow-up, a significant negative association between SSEP and body mass index (BMI), weight change, and waist circumference change was observed (25 ≤ age < 65, n = 526), which was particularly important in adults receiving medications with the highest risk of weight gain, with a BMI difference of 0.86 kg/m(2) between patients with low versus high SSEP (95% CI: 0.03–1.70, n = 99). Eventually, a causal effect of EA on BMI was revealed using Mendelian randomization in the UKBiobank, which was notably strong in high-risk medication users (beta: −0.47 SD EA per 1 SD BMI; 95% CI: −0.46 to −0.27, n = 11,314). An additional aspect of personalized medicine was highlighted, suggesting the patients’ SES represents a significant risk factor. Particular attention should be paid to patients with low SES when initiating high cardiometabolic risk psychotropic medications