Health Literacy of Individuals Living with Parkinson\u27s Disease

In the past two decades, there has been an increased interest in the development of self-management programs for people with chronic diseases. Fundamental to chronic disease management is adequate literacy and health literacy skills. Research on the health literacy skills of individuals managing Parkinson’s disease (PD) is seemingly absent from the research literature. The purpose of this study was to assess the health literacy skills of older adults managing PD and to examine the relationships of functional health literacy, self-efficacy, social support, and empowerment in this population. Using a cross-sectional design, this study surveyed 33 older adults living with PD within southwestern Ontario. Functional health literacy was positively correlated with self-efficacy (r=.13) and empowerment (r=.20) in individuals living with PD. As well, there was an association between functional health literacy and social support. Findings suggest that self-efficacy, social support, and empowerment may affect PD patients’ ability to find, read, understand, and communicate health-related information. Keywords: Parkinson’s disease, functional health literacy, self-efficacy, empowerment, social suppor

Olfactory stimuli associated with the different stages of vertebrate decomposition and their role in the attraction of the blowfly calliphora vomitoria (Diptera: Calliphoridae) to carcasses

Digitised version available at EThOS: British Library Electronic Theses Online Servic

Tv-RIO1 – an atypical protein kinase from the parasitic nematode Trichostrongylus vitrinus

Background: Protein kinases are key enzymes that regulate a wide range of cellular processes, including cell-cycle progression, transcription, DNA replication and metabolic functions. These enzymes catalyse the transfer of phosphates to serine, threonine and tyrosine residues, thus playing functional roles in reversible protein phosphorylation. There are two main groups, namely eukaryotic protein kinases (ePKs) and atypical protein kinases (aPKs); RIO kinases belong to the latter group. While there is some information about RIO kinases and their roles in animals, nothing is known about them in parasites. This is the first study to characterise a RIO1 kinase from any parasite. Results: A full-length cDNA (Tv-rio-1) encoding a RIO1 protein kinase (Tv-RIO1) was isolated from the economically important parasitic nematode Trichostrongylus vitrinus (Order Strongylida). The uninterrupted open reading frame (ORF) of 1476 nucleotides encoded a protein of 491 amino acids, containing the characteristic RIO1 motif LVHADLSEYNTL. Tv-rio-1 was transcribed at the highest level in the third-stage larva (L3), and a higher level in adult females than in males. Comparison with homologues from other organisms showed that protein Tv-RIO1 had significant homology to related proteins from a range of metazoans and plants. Amino acid sequence identity was most pronounced in the ATP-binding motif, active site and metal binding loop. Phylogenetic analyses of selected amino acid sequence data revealed Tv-RIO1 to be most closely related to the proteins in the species of Caenorhabditis. A structural model of Tv-RIO1 was constructed and compared with the published crystal structure of RIO1 of Archaeoglobus fulgidus (Af-Rio1). Conclusion: This study provides the first insights into the RIO1 protein kinases of nematodes, and a foundation for further investigations into the biochemical and functional roles of this molecule in biological processes in parasitic nematodes

Monte Carlo Simulations of Polarimetric and Light Variability from Corotating Interaction Regions in Hot Stellar Winds

We use a 3D Monte Carlo radiative transfer code to study the polarimetric and photometric variability from stationary corotating interaction regions (CIR) in the wind of massive stars. Our CIRs are approximated by Archimedean spirals of higher (or lower) density formed in a spherical wind originating from the star and we also made allowance for a bright gaussian spot at the base of the CIR. Comparing results from our code to previous analytical calculations in the optically thin case, we find differences which we attribute mainly to a better estimation of the total unpolarized flux reaching the observer. In the optically thick case, the differences with the analytical calculations are much larger, as multiple scattering introduces extra complexities including occultation effects. The addition of a gaussian spot does not alter the shape of the polarization curve significantly but does create a small excess in polarization. On the other hand, the effect can be larger on the light curve and can become dominant over the resulting CIR, depending on the spot parameters and density of the wind.Comment: 16 pages, 17 figure

The Relationship between Perceived Social Support and Severity of Body Dysmorphic Disorder Symptoms: The Role of Gender

OBJECTIVE: Whether social support is associated with severity of body dysmorphic symptoms is unknown. To address this gap in the literature, the present study aims to examine the association between three domains of perceived social support (i.e., family, friends, and significant others) and severity of body dysmorphic disorder symptoms. METHOD: Participants (N = 400) with symptoms consistent with diagnosis of body dysmorphic disorder completed measures of symptomatology and social support via the internet. RESULTS: More perceived social support from friends and significant others was associated with less severe body dysmorphic disorder symptoms for males, and more perceived social support from family and friends was associated with less severe body dysmorphic disorder symptoms among females. Additionally, gender moderated the association between perceived social support from significant others and symptom severity, such that perceived social support from a significant other was significantly negatively associated with body dysmorphic symptom severity in males, but not females. CONCLUSION: The present study implicates social support as an important area of future body dysmorphic disorder research

Clinicians' Understanding of Preferences and Values of People with Hematological Malignancies at the End of Life: Concurrent Surveys

Background: People with hematological malignancies can deteriorate rapidly to a terminal event and have variable levels of engagement when transitioning to palliative and end-of-life care. Objectives: To describe end-of-life care values and preferences of people with hematological malignancies and explore whether these align with hematology clinicians' perceptions. Design: Two matched anonymous quantitative cross-sectional surveys explored: (1) patients' values and preferences around manner and timing of discussions regarding life expectancy and prognosis, involvement in decision making, and concurrent integration of palliative care with active treatment; and (2) clinicians' perceptions of their patients' values and preferences in relation to prognostic information. Settings/Participants: Concurrent online national surveys of people with hematological malignancies known to the Leukemia Foundation of Australia, and clinicians in Australia with membership to the Hematology Society of Australia and New Zealand. Results: Five hundred nine (38% response rate) patients (median age 64 [min 20, max 89, interquartile range 56-70]) and 272 clinicians (21% response rate) responded to the survey. If their health was deteriorating, most patients wanted honest prognostic and life expectancy information (87%); welcomed involvement in decision making (94%); felt they would be comfortable talking to the treating team about the possibility of death (86%); and would be comfortable seeing someone from a specialist palliative care team (74%). Clinicians generally underestimated most of these responses. Conclusion: Although our findings indicate that most people believe they would be comfortable discussing prognosis, life expectancy, and wishes at the end of life, clinicians were largely unaware of their preferences. This highlights the need to embed values clarification in routine care for each patient and family.</p

The Truth Comes From Us: Supporting Workers with Developmental Disabilities

Employment professionals play a powerful role in the pursuit of true inclusion. This paper by self-advocates outlines key steps on how allies can move people with developmental disabilities out of poverty and into the heart of our communities

Person-Centered Practice as Anchor and Beacon: Pandemic Wisdom from the NCAPPS Community

Objective: This article summarizes the individual, systemic, and collective challenges and opportunities presented by the COVID-19 pandemic, based on 16 videos solicited by the National Center on Advancing Person-Centered Practices and Systems (NCAPPS) and submitted by NCAPPS collaborators during the first six months of the pandemic. Method: Informed by participatory action approaches and content analysis, we describe common themes in a series of 16 videos solicited by NCAPPS from subject matter experts with professional and lived experience of disability and human services systems. Results: The team organized the findings to identify both specific factors within each of the levels and the complex interplay between each of the factors at four levels: (1) individual disabled people and their/our spouses, family, and friends; (2) person-centered strategies; (3) system, services, and providers; and (4) society. Discussion: Practices such as person-centered planning, peer support, and self-direction enable us to respond to and cope with the traumas caused by the pandemic. Systems-level themes reveal clear opportunities for abandoning outdated practices and rebuilding the service system in a more person-centered manner. Commentators argued that a society that strives for collective responsibility and well-being and leaves no one behind will generate the interdependence necessary to weather disasters like the COVID-19 pandemic. Conclusion: Person-centered practices are both an anchor for weathering the pandemic and a beacon for rebuilding lives, service systems, and communities

Revue d'histoire du Bas-Saint-Laurent, vol. 14 (2)

Éditorial -- Enseignement -- Archéologie -- Mont Commis ou Mont Camille? -- Joachim Vautour, pêcheur résidant à Rimouski au XVIIIe siècle -- Les guerres du bois -- L'incorporation de Trois-Pistoles a donné lieu à une série de conflits (1916-1924) -- Chroniques rimouskoises -- Histoire orale -- Patrimoine -- Archives -- Des livres à lire! -- Photos ancienne