47 research outputs found
Adaptive Physically Based Models in Computer Graphics
International audienceOne of the major challenges in physically-based modeling is making simulations efficient. Adaptive models provide an essential solution to these efficiency goals. These models are able to self-adapt in space and time, attempting to provide the best possible compromise between accuracy and speed. This survey reviews the adaptive solutions proposed so far in computer graphics. Models are classified according to the strategy they use for adaptation, from time-stepping and freezing techniques to geometric adaptivity in the form of structured grids, meshes, and particles. Applications range from fluids, through deformable bodies, to articulated solids
Germline selection shapes human mitochondrial DNA diversity.
Approximately 2.4% of the human mitochondrial DNA (mtDNA) genome exhibits common homoplasmic genetic variation. We analyzed 12,975 whole-genome sequences to show that 45.1% of individuals from 1526 mother-offspring pairs harbor a mixed population of mtDNA (heteroplasmy), but the propensity for maternal transmission differs across the mitochondrial genome. Over one generation, we observed selection both for and against variants in specific genomic regions; known variants were more likely to be transmitted than previously unknown variants. However, new heteroplasmies were more likely to match the nuclear genetic ancestry as opposed to the ancestry of the mitochondrial genome on which the mutations occurred, validating our findings in 40,325 individuals. Thus, human mtDNA at the population level is shaped by selective forces within the female germ line under nuclear genetic control, which ensures consistency between the two independent genetic lineages.NIHR, Wellcome Trust, MRC, Genomics Englan
A critical examination of Laski’s political doctrines.
Few living political thinkers are better known than Professor Harold Laski. Educated at Oxford, he came to this continent during world war I and taught first at McGill and afterwards at Harvard. At both universities he promptly got into hot water with the authorities for publicly expressing (to them) objectionable opinions. Receiving an appointment as lecturer at the London School of Economics, Laski returned to England in 1920. A prolific writer, he has built up a solid and enviable reputation for exact scholarship (all who have met or heard Laski testify to his phenomenal memory) brilliant rhetoric and complete sincerity. A forceful and eloquent speaker, he has received this century's most positive accolade of fame - his speeches are reported. Today, the chairman and influential spokesman, he is also sometimes referred to as the one-man brain trust of the British Labour Party.[...