Serum C-peptide level as a predictor of atherosclerosis and cardiovascular disease in type 2 diabetes mellitus

Objective: To assess the correlation of serum C-peptide level to carotid intima media thickness (a surrogate marker of atherosclerosis) and risk of developing cardiovascular disease (CVD) in type 2 diabetes patients as determined by United Kingdom Prospective Diabetes Study (UKPDS) risk engine. Materials and Methods: About 101 cases of diabetes mellitus (DM) type 2 (diagnosed according to American Diabetes Association 2007 criteria) were subjected to detail clinical examination and laboratory investigations. The intima media thickness of both carotid arteries (CIMT) was measured for each patient with color Doppler. The risk of CVD was calculated using UKPDS risk engine. Observations: Age of subjects, glycated hemoglobin (HbA1c), body mass index (BMI), levels of systolic blood pressure (SBP), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-DL (LDL), homocysteine, CIMT, and the 10 years CVD risk according to the UKPDS were significantly different across the C-peptide quartiles (P for trend <0.05). Significant positive correlations of C-peptide levels were found with age of subjects, duration of DM, BMI, fasting plasma glucose, HbA1c, SBP, TC, TG, LDL, and homocysteine. Significant negative correlation of C-peptide levels was observed with HDL. C-peptide levels had significant positive correlation with CIMT (atherosclerosis) and 10 years CVD risk (future CVD) by UKPDS risk engine. Conclusions: Serum C-peptide level seems to be significantly related to the development of atherosclerosis and future CVD in type 2 DM. It may be used as a predictor of subclinical atherosclerosis and CVD in these patients

ISSN 2347-954X (Print) Metabolic Syndrome and Sub Clinical Atherosclerosis: Influence of HIV Status and HAART

Abstract: The aim was to detect and compare metabolic syndrome and sub clinical atherosclerosis in HIV patients on ART/ not on ART and normal populatio

7th International Conference on Recent Advances in Mathematical Sciences and its Applications-2024: Abstract Book

This book presents the abstracts of the selected contributions to the 7th International Conference on Recent Advances in Mathematical Sciences and its Applications (RAMSA 2024), held on 29 February- 02 March 2024, by the Department of Mathematics, Jaypee Institute of Information Technology, Noida, India. RAMSA 2024 aims to assemble esteemed mathematicians, scientists, engineers, researchers from industry, and scholars, facilitating a platform for the exchange of ideas and discussions on recent advancements across various areas of mathematics. RAMSA-2024 provides an opportunity to delve into research findings and breakthroughs in mathematics, sciences, and engineering. This conference serves as a forum to address practical challenges encountered in different application domains and explore potential solutions. Conference Title: 7th International Conference on Recent Advances in Mathematical Sciences and its ApplicationsConference Acronym: RAMSA-2024Conference Date: 29 Feb-02 March 2024Conference Venue: Hybrid Mode (JIIT Noida &amp; Online)Conference Organizer: Department of Mathematics, Jaypee Institute of Information Technology, Noida, Indi