1,677 research outputs found

    Vacuum stability, fixed points, and phases of QED3 at large Nf

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    We consider three-dimensional quantum electrodynamics in the presence of a Chern-Simons term at level k and Nf flavors, in the limit of large Nf and k with k/Nf fixed. We consider either bosonic or fermionic matter fields, with and without quartic terms at criticality: the resulting theories are critical and tricritical bosonic QED3, Gross-Neveu, and fermionic QED3. For all such theories we compute the effective potentials and the beta functions of classically marginal couplings, at the leading order in the large Nf limit and to all orders in k/Nf and in the couplings. We determine the renormalization group fixed points and discuss the quantum stability of the corresponding vacua. While critical bosonic and fermionic QED3 are always stable conformal field theories, we find that tricritical bosonic and Gross-Neveu QED3 exist as stable conformal field theories only for specific values of k/Nf. Finally, we discuss the phase diagrams of these theories as a function of their relevant deformations

    Electromechanical actuators affected by multiple failures: a simulated-annealing-based fault identification algorithm

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    The identification of early evidences on monitored parameters allows preventing incoming faults. Early alerts can avoid rate of the failures and trigger proper out-of-schedule maintenance activities. For this purpose, there are many prognostic approaches. This paper takes into account a primary flight command electromechanical actuator (EMA) with multiple failures originating from progressive wear and proposes a fault detection approach that identifies symptoms of EMA degradation through a simulated annealing (SA) optimization algorithm; in particular, the present work analyses the functioning of this prognostic tool in three different fault configurations and it focuses on the consequences of multiple failures. For this purpose, we developed a test bench and obtained experimental data necessary to validate the results originated from the model. Such comparison demonstrates that this method is affordable and able to detect failures before they occur, thus reducing the occurrence of false alarms or unexpected failures. © 2016, North Atlantic University Union. All rights reserved

    Linear Electromechanical Actuators Affected by Mechanical Backlash: a Fault Identification Method Based on Simulated Annealing Algorithm

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    Several approaches can be employed in prognostics, to detect incipient failures of primary flight command electromechanical actuators (EMA), caused by progressive wear. The development of a prognostic algorithm capable of identifying the precursors of an electromechanical actuator failure is beneficial for the anticipation of the incoming faults: a correct interpretation of the fault degradation pattern, in fact, can trig an early alert of the maintenance crew, who can properly schedule the servomechanism replacement. The research presented in this paper proposes a fault detection / identification technique, based on approaches derived from optimization methods, able to identify symptoms of EMA degradation before the actual exhibition of the anomalous behavior; in particular, the authors’ work analyses the effects due to progressive backlashes acting on the mechanical transmission and evaluates the effectiveness of the proposed approach to correctly identify these faults. An experimental test bench was developed: results show that the method exhibit adequate robustness and a high degree of confidence in the ability to early identify an eventual fault, minimizing the risk of false alarms or not annunciated failures

    Root photosynthesis prevents hypoxia in the epiphytic orchid Phalaenopsis

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    Orchids (Phalaenopsis spp.) growing in tropical and subtropical regions are epiphytes. As such, they grow on trees with the root system utilised to anchor themselves to tree branches. These roots are highly specialised, display a large diameter and are often green, suggesting the ability to carry out photosynthesis. However, the role of photosynthesis in orchid roots is controversial. Orchids that are leafless can photosynthesise in their roots, thus indicating that some orchid roots carry out photosynthesis in a similar manner to leaves. However, the primary site of photosynthesis in orchids are in their leaves, and the roots of epiphytic orchids may mostly conduct internal refixation of respiratory CO2. Besides contributing to the overall carbon metabolism of orchid plants, oxygen produced through root photosynthesis may also be important by alleviating potential root hypoxia. The bulky tissue of most epiphytic orchid roots suggests that oxygen diffusion in these roots can be limited. Here, we demonstrate that the bulky roots of a widely commercially cultivated orchid belonging to the genus Phalaenopsis are hypoxic in the dark. These roots are photosynthetically active and produce oxygen when exposed to light, thus mitigating root hypoxia

    Optical Emission Spectroscopy Diagnostics of Cold Plasmas for Food Sterilization

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    There is a growing need for economical, effective, and safe methods of sterilizing fresh produce. The most common method is a chlorine wash, which is expensive and may introduce carcinogens. High voltage cold atmospheric pressure plasmas are a promising solution that has demonstrated a germicidal effect; however, the responsible chemical mechanisms and reaction pathways are not fully understood. To elucidate this chemistry, we used optical emission spectroscopy to measure the species produced in the plasma generated by a 60 Hz pulsed dielectric barrier discharge in a plastic box containing various fill gases (He, N2, CO2, dry air, or humid air). In addition to estimating chemical species concentrations, we performed preliminary calculations of electronic, vibrational, rotational, and translational temperatures

    Cold Atmospheric Pressure Plasmas for Food Applications

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    Successfully distributing shelf food requires treatment to eliminate microorganisms. Current chemical methods, such as chlorine wash, can alter food quality while only being effective for a limited time. Cold atmospheric pressure plasmas (CAPs) can eradicate the microorganisms responsible for food spoilage and foodborne illness. Optimizing CAP treatments requires understanding the reactive species generated and relating them to eradication efficiency. Recent studies have used optical emission spectroscopy (OES) to determine the species generated in a sealed package that would hold food. In this study,we supplement the OES results with optical absorption spectroscopy (OAS) using the same gases (helium, nitrogen, compressed air, humid air) to elucidate plasma chemistry and temperature. We first reproduce previous results using a new setup while assessing the impact of the package and surrounding box on the plasma spectrum. A UV-Vis light lightsource is emitted through a series of lenses placed next to the plasma. Analysis using SpecAir software allows the identification of absorbed peaks and the calculation of rotational, vibrational, and electron temperatures. Results show that the air plasma produces a primary absorbance peak at a wavelength of ~260 nm, demonstrating the diagnostic capability of this technique . Species generation declined dramatically during the first two minutes of treatment with the effect leveling off thereafter. These findings elucidate reactive species generation within the plasma to optimize CAP systems for microorganism decontamination

    The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology

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    Small fibre neuropathy (SFN), a condition dominated by neuropathic pain, is frequently encountered in clinical practise either as prevalent manifestation of more diffuse neuropathy or distinct nosologic entity. Aetiology of SFN includes pre-diabetes status and immune-mediated diseases, though it remains frequently unknown. Due to their physiologic characteristics, small nerve fibres cannot be investigated by routine electrophysiological tests, making the diagnosis particularly difficult. Quantitative sensory testing (QST) to assess the psychophysical thresholds for cold and warm sensations and skin biopsy with quantification of somatic intraepidermal nerve fibres (IENF) have been used to determine the damage to small nerve fibres. Nevertheless, the diagnostic criteria for SFN have not been defined yet and a ‘gold standard’ for clinical practise and research is not available. We screened 486 patients referred to our institutions and collected 124 patients with sensory neuropathy. Among them, we identified 67 patients with pure SFN using a new diagnostic ‘gold standard’, based on the presence of at least two abnormal results at clinical, QST and skin biopsy examination. The diagnosis of SFN was achieved by abnormal clinical and skin biopsy findings in 43.3% of patients, abnormal skin biopsy and QST findings in 37.3% of patients, abnormal clinical and QST findings in 11.9% of patients, whereas 7.5% patients had abnormal results at all the examinations. Skin biopsy showed a diagnostic efficiency of 88.4%, clinical examination of 54.6% and QST of 46.9%. Receiver operating characteristic curve analysis confirmed the significantly higher performance of skin biopsy comparing with QST. However, we found a significant inverse correlation between IENF density and both cold and warm thresholds at the leg. Clinical examination revealed pinprick and thermal hypoesthesia in about 50% patients, and signs of peripheral vascular autonomic dysfunction in about 70% of patients. Spontaneous pain dominated the clinical picture in most SFN patients. Neuropathic pain intensity was more severe in patients with SFN than in patients with large or mixed fibre neuropathy, but there was no significant correlation with IENF density. The aetiology of SFN was initially unknown in 41.8% of patients and at 2-year follow-up a potential cause could be determined in 25% of them. Over the same period, 13% of SFN patients showed the involvement of large nerve fibres, whereas in 45.6% of them the clinical picture did not change. Spontaneous remission of neuropathic pain occurred in 10.9% of SFN patients, while it worsened in 30.4% of them

    In silico identification of small molecules as new cdc25 inhibitors through the correlation between chemosensitivity and protein expression pattern

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    The cell division cycle 25 (Cdc25) protein family plays a crucial role in controlling cell proliferation, making it an excellent target for cancer therapy. In this work, a set of small molecules were identified as Cdc25 modulators by applying a mixed ligand-structure-based approach and taking advantage of the correlation between the chemosensitivity of selected structures and the protein expression pattern of the proposed target. In the first step of the in silico protocol, a set of molecules acting as Cdc25 inhibitors were identified through a new ligand-based protocol and the evaluation of a large database of molecular structures. Subsequently, induced-fit docking (IFD) studies allowed us to further reduce the number of compounds biologically screened. In vitro antiproliferative and enzymatic inhibition assays on the selected compounds led to the identification of new structurally heterogeneous inhibitors of Cdc25 proteins. Among them, J3955, the most active inhibitor, showed concentration-dependent antiproliferative activity against HepG2 cells, with GI50 in the low micromolar range. When J3955 was tested in cell-cycle perturbation experiments, it caused mitotic failure by G2/M-phase cell-cycle arrest. Finally, Western blotting analysis showed an increment of phosphorylated Cdk1 levels in cells exposed to J3955, indicating its specific influence in cellular pathways involving Cdc25 proteins
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