Interrogating Systems That Cause Disparities: Testing the Social-Ecological Model in Low- Versus High-Density African American Communities

This study utilized the four-level social-ecological model to provide a better understanding of the disparities in health-related outcomes in high- and low-density African American (AA) communities. The current research sought to understand the relationships between mental and physical health, social-economic factors, and physical environment within this community. The goal of this study was to understand the relationship between these indicators of health, to better inform health-care strategies. The results highlight the significant difference between high- and low-density AA communities and socio-economic factors, physical environment, poor physical days, and poor mental health days. Implications for behavioral health providers are explored

Slaves, Soldiers, Citizens: African American Artifacts of the Civil War Era

Based on the exhibit Slaves, Soldiers, Citizens: African American Artifacts of the Civil War Era, this book provides the full experience of the exhibit, which was on display in Special Collections at Musselman Library November 2012- December 2013. It also includes several student essays based on specific artifacts that were part of the exhibit. Table of Contents: Introduction Angelo Scarlato, Lauren Roedner ’13 & Scott Hancock Slave Collars & Runaways: Punishment for Rebellious Slaves Jordan Cinderich ’14 Chancery Sale Poster & Auctioneer’s Coin: The Lucrative Business of Slavery Tricia Runzel ’13 Isaac J. Winters: An African American Soldier from Pennsylvania Who Fought at Petersburg Avery Lentz ’14 Basil Biggs: A Prominent African American in Gettysburg after the Battle Lauren Roedner ’13 Linton Ingram: A Former Slave Who Became a Notable African American Educator in Georgia Brian Johnson & Lincoln Fitch ’14 Uncle Tom’s Cabin Theatre Poster: Racism in Post-Emancipation Entertainment Michelle Seabrook ’13 Essay Bibliographies Grand Army of the Republic Exhibit Inventory Acknowledgmentshttps://cupola.gettysburg.edu/libexhibits/1001/thumbnail.jp

Structural Heat Intercept, Insulation and Vibration Evaluation Rig (SHIIVER)

The Structural Heat Intercept, Insulation, and Vibration Evaluation Rig (SHIIVER) is a large scale cryogenic fluid management (CFM) test bed designed to scale CFM technologies for inclusion on large, in-space stages. A part of the evolvable Cryogenics (eCryo) project, SHIIVER is a technology development task that is supportive of future exploration propulsion needs. Technologies developed under the eCryo Project will play a critical role in enabling increasingly longer duration in-space missions beyond Low Earth Orbit (LEO)

High Fidelity Collision Probabilities Estimated Using Brute Force Monte Carlo Simulations

The NASA Conjunction Assessment Risk Analysis team has implemented new software to estimate the probability of collision (P (sub c)) for Earth-orbiting satellites. The algorithm employs a brute force Monte Carlo (BFMC) method which differs from most other methods because it uses orbital states and covariances propagated from their orbit determination epoch times using the full set of Astrodynamics Support Workstation higher order theory models, including the High Accuracy Satellite Drag Model. This paper de-scribes the BFMC algorithm, presents comparisons of BFMC P (sub c) estimates to those calculated using other methods, and discusses the implications for conjunction risk assessment

Comparative outcomes between COVID-19 and influenza patients placed on veno-venous extracorporeal membrane oxygenation for severe ARDS

Background ECMO is an established supportive adjunct for patients with severe, refractory ARDS from viral pneumonia. However, the exact role and timing of ECMO for COVID-19 patients remains unclear. Methods We conducted a retrospective comparison of the first 32 patients with COVID-19-associated ARDS to the last 28 patients with influenza-associated ARDS placed on V-V ECMO. We compared patient factors between the two cohorts and used survival analysis to compare the hazard of mortality over sixty days post-cannulation.Results COVID-19 patients were older (mean 47.8 vs. 41.2 years, p = 0.033), had more ventilator days before cannulation (mean 4.5 vs. 1.5 days, p < 0.001). Crude in-hospital mortality was significantly higher in the COVID-19 cohort at 65.6% (n = 21/32) versus 36.3% (n = 11/28, p = 0.041). The adjusted hazard ratio over sixty days for COVID-19 patients was 2.81 (95% CI 1.07, 7.35) after adjusting for age, race, ECMO-associated organ failure, and Charlson Comorbidity Index. Conclusion ECMO has a role in severe ARDS associated with COVID-19 but providers should carefully weigh patient factors when utilizing this scarce resource in favor of influenza pneumonia

A Genome-Wide Screen Identifies Genes That Affect Somatic Homolog Pairing in Drosophila

In Drosophila and other Dipterans, homologous chromosomes are in close contact in virtually all nuclei, a phenomenon known as somatic homolog pairing. Although homolog pairing has been recognized for over a century, relatively little is known about its regulation. We performed a genome-wide RNAi-based screen that monitored the X-specific localization of the male-specific lethal (MSL) complex, and we identified 59 candidate genes whose knockdown via RNAi causes a change in the pattern of MSL staining that is consistent with a disruption of X-chromosomal homolog pairing. Using DNA fluorescent in situ hybridization (FISH), we confirmed that knockdown of 17 of these genes has a dramatic effect on pairing of the 359 bp repeat at the base of the X. Furthermore, dsRNAs targeting Pr-set7, which encodes an H4K20 methyltransferase, cause a modest disruption in somatic homolog pairing. Consistent with our results in cultured cells, a classical mutation in one of the strongest candidate genes, pebble (pbl), causes a decrease in somatic homolog pairing in developing embryos. Interestingly, many of the genes identified by our screen have known roles in diverse cell-cycle events, suggesting an important link between somatic homolog pairing and the choreography of chromosomes during the cell cycle

Extravascular fibrinogen in the white matter of Alzheimer's disease and normal aged brains : implications for fibrinogen as a biomarker for Alzheimer's disease

The research was supported by the Alzheimer’s Society (grant numbers AS-PG-2013-011 and AS-JF-18-01). Tissue for this study was provided by the Newcastle Brain Tissue Resource, which is funded in part by a grant from the UK Medical Research Council (G0400074) and by Brains for Dementia research, a joint venture between Alzheimer’s Society and Alzheimer’s Research UK.The blood‐brain barrier (BBB) regulates cerebrovascular permeability and leakage of blood‐derived fibrinogen has been associated with cerebral arteriolosclerosis small vessel disease (SVD) and subsequent white matter lesions (WML). Furthermore, BBB‐dysfunction is associated with the pathogenesis of Alzheimer's disease (AD) with the presence of CSF plasma proteins suggested to be a potential biomarker of AD. We aimed to determine if extravascular fibrinogen in the white matter was associated with the development of AD hallmark pathologies, i.e., hyperphosphorylated tau (HPτ) and amyloid‐β (Aβ), SVD, cerebral amyloid angiopathy (CAA) and measures of white matter damage. Using human post‐mortem brains, parietal tissue from 20 AD and 22 non‐demented controls was quantitatively assessed for HPτ, Aβ, white matter damage severity, axonal density, demyelination and the burden of extravascular fibrinogen in both WML and normal appearing white matter (NAWM). SVD severity was determined by calculating sclerotic indices. WML‐ and NAWM fibrinogen burden was not significantly different between AD and controls nor was it associated with the burden of HPτ or Aβ pathology, or any measures of white matter damage. Increasing severity of SVD was associated with and a predictor (both p < 0.05) of both higher WML‐ and NAWM fibrinogen burden (both P<0.05) in controls only. In cases with minimal SVD NAWM fibrinogen burden was significantly higher in the AD cases (p<0.05). BBB dysfunction was present in both non‐demented and AD brains and was not associated with the burden of AD‐associated cortical pathologies. BBB dysfunction was strongly associated with SVD but only in the non‐demented controls. In cases with minimal SVD, BBB dysfunction was significantly worse in AD cases possibly indicating the influence of CAA. In conclusions, extravascular fibrinogen is not associated with AD hallmark pathologies but indicates SVD, suggesting that the presence of fibrinogen in the CSF is not a surrogate marker for AD pathology.PostprintPeer reviewe

Understanding Occupational Injury and Substance Use Issues among Workers in the Shellfish and Lobster Industries

In 2022, American lobster (Homarus americanus) and softshell clam (Mya arenaria) harvests contributed $283 million to Downeast Maine’s economy, employing thousands of harvesters. Harvesting is grueling work. Pain from work-related injuries precedes most opioid deaths, and workers in fisheries are disproportionately at risk. Harvesters are typically self-employed and often uninsured or underinsured, complicating access to care. Prior studies have focused on injury risk or drug use among harvesters without revealing how injury, pain and substance use intertwine with cultural, social and regulatory factors. This study examined the socio-ecologically embedded injury/ pain/ substance use process with surveys of harvesters (n=106) and healthcare providers and advocates (n=31) followed by interviews of harvesters (n=13) and providers (n=8). We found that harvesters are extremely prone to injury from myriad causes. Shellfish harvesters were more injury-prone and socially vulnerable than lobster harvesters. Deferral of care, problems with healthcare access, age, lack of cultural competency among healthcare providers, and challenges with financial stability were linked to poor outcomes. Interviewees shared many anecdotes of addiction and overdose stemming from injury. Self-medication with substances other than opioids was also prevalent, indicating widespread pain-related challenges. Participants reported family disruption and incarceration related to substance use disorder, and common comorbidities included hepatitis-C, HIV and organ failure. Consultation with community partners yielded recommendations to support health and keep Maine\u27s fisheries afloat, including community-embedded healthcare services, fisheries policy arrangements that reduce injury risk and incentivize health, financial education for managing boom and bust cycles, and expanded insurance programs