Rotation in NGC 2264: a study based on CoRoT photometric observations

Rotation is one of the key stellar parameters which undergo substantial evolution during the stellar lifetime, in particular during the early stages. Stellar rotational periods can be determined on the basis of the periodic modulation of starlight produced by non-uniformities on the surface of the stars, due to manifestation of stellar activity. We present the results of an extensive search for rotational periods among NGC 2264 cluster members, based on photometric monitoring using the CoRoT satellite, with a particular attention to the distribution of classical and weak-line T-Tauri stars. NGC 2264 is one of the nearest and best studied star forming region in the solar neighbourhood, with an estimated age of 3 Myr, and is the object of a recent simultaneous multiband campaign including a new CoRoT observation with the aim to assess the physical origin of the observed variability. We find that the rotational distributions of classical and weak-line T-Tauri star are different, suggesting a difference in the rotational properties of accreting and non-accreting stars.Comment: 15 pages, 10 figure

Stellar masks and bisector's shape for M-type stars observed in the GAPS Programme with HARPS-N at TNG

The HARPS/HARPS-N Data Reduction Software (DRS) relies on the cross-correlation between the observed spectra and a suitable stellar mask to compute a cross-correlation function (CCF) to be used both for the radial velocity (RV) computation and as an indicator of stellar lines asymmetry, induced for example by the stellar activity. Unfortunately the M2 mask currently used by the HARPS/HARPS-N DRS for M-type stars results in heavily distorted CCFs. We created several new stellar masks in order to decrease the errors in the RVs and to improve the reliability of the activity indicators as the bisector's span. We obtained very good results with a stellar mask created from the theoretical line list provided by the VALD3 database for an early M-type star (T$_{\mathrm{eff}}$=3500~K and $\log{g}=4.5$). The CCF's shape and relative activity indicators improved and the RV time-series allowed us to recover known exoplanets with periods and amplitudes compatible with the results obtained with HARPS-TERRA.Comment: 13 pages, 8 figures Accepted for publication in Experimental Astronom

Geometry Diagnostics of a Stellar Flare from Fluorescent X-rays

We present evidence of Fe fluorescent emission in the Chandra HETGS spectrum of the single G-type giant HR 9024 during a large flare. In analogy to solar X-ray observations, we interpret the observed Fe K$\alpha$ line as being produced by illumination of the photosphere by ionizing coronal X-rays, in which case, for a given Fe photospheric abundance, its intensity depends on the height of the X-ray source. The HETGS observations, together with 3D Monte Carlo calculations to model the fluorescence emission, are used to obtain a direct geometric constraint on the scale height of the flaring coronal plasma. We compute the Fe fluorescent emission induced by the emission of a single flaring coronal loop which well reproduces the observed X-ray temporal and spectral properties according to a detailed hydrodynamic modeling. The predicted Fe fluorescent emission is in good agreement with the observed value within observational uncertainties, pointing to a scale height $\lesssim 0.3$\rstar. Comparison of the HR 9024 flare with that recently observed on II Peg by Swift indicates the latter is consistent with excitation by X-ray photoionization.Comment: accepted for publication on the Astrophysical Journal Letter

Kepler-21b: A Rocky Planet Around a V = 8.25 Magnitude Star

HD 179070, aka Kepler-21, is a V = 8.25 F6IV star and the brightest exoplanet host discovered by Kepler. An early detailed analysis by Howell et al. (2012) of the first thirteen months (Q0 - Q5) of Kepler light curves revealed transits of a planetary companion, Kepler-21b, with a radius of about 1.60 ± 0.04 R⊕ and an orbital period of about 2.7857 days. However, they could not determine the mass of the planet from the initial radial velocity observations with Keck-HIRES, and were only able to impose a 2σ upper limit of 10 M⊕. Here we present results from the analysis of 82 new radial velocity observations of this system obtained with HARPS-N, together with the existing 14 HIRES data points. We detect the Doppler signal of Kepler-21b with a radial velocity semi-amplitude K = 2.00 ± 0.65 m s-1, which corresponds to a planetary mass of 5.1 ± 1.7 M⊕. We also measure an improved radius for the planet of 1.639 +0.019/-0.015 R⊕, in agreement with the radius reported by Howell et al. (2012). We conclude that Kepler-21b, with a density of 6.4 ± 2.1 g cm-3, belongs to the population of small, ≤6 M⊕ planets with iron and magnesium silicate interiors, which have lost the majority of their envelope volatiles via stellar winds or gravitational escape. The RV analysis presented in this paper serves as example of the type of analysis that will be necessary to confirm the masses of TESS small planet candidates.PostprintPeer reviewe

A chemical survey of exoplanets with ARIEL

Thousands of exoplanets have now been discovered with a huge range of masses, sizes and orbits: from rocky Earth-like planets to large gas giants grazing the surface of their host star. However, the essential nature of these exoplanets remains largely mysterious: there is no known, discernible pattern linking the presence, size, or orbital parameters of a planet to the nature of its parent star. We have little idea whether the chemistry of a planet is linked to its formation environment, or whether the type of host star drives the physics and chemistry of the planet’s birth, and evolution. ARIEL was conceived to observe a large number (~1000) of transiting planets for statistical understanding, including gas giants, Neptunes, super-Earths and Earth-size planets around a range of host star types using transit spectroscopy in the 1.25–7.8 μm spectral range and multiple narrow-band photometry in the optical. ARIEL will focus on warm and hot planets to take advantage of their well-mixed atmospheres which should show minimal condensation and sequestration of high-Z materials compared to their colder Solar System siblings. Said warm and hot atmospheres are expected to be more representative of the planetary bulk composition. Observations of these warm/hot exoplanets, and in particular of their elemental composition (especially C, O, N, S, Si), will allow the understanding of the early stages of planetary and atmospheric formation during the nebular phase and the following few million years. ARIEL will thus provide a representative picture of the chemical nature of the exoplanets and relate this directly to the type and chemical environment of the host star. ARIEL is designed as a dedicated survey mission for combined-light spectroscopy, capable of observing a large and well-defined planet sample within its 4-year mission lifetime. Transit, eclipse and phase-curve spectroscopy methods, whereby the signal from the star and planet are differentiated using knowledge of the planetary ephemerides, allow us to measure atmospheric signals from the planet at levels of 10–100 part per million (ppm) relative to the star and, given the bright nature of targets, also allows more sophisticated techniques, such as eclipse mapping, to give a deeper insight into the nature of the atmosphere. These types of observations require a stable payload and satellite platform with broad, instantaneous wavelength coverage to detect many molecular species, probe the thermal structure, identify clouds and monitor the stellar activity. The wavelength range proposed covers all the expected major atmospheric gases from e.g. H2O, CO2, CH4 NH3, HCN, H2S through to the more exotic metallic compounds, such as TiO, VO, and condensed species. Simulations of ARIEL performance in conducting exoplanet surveys have been performed – using conservative estimates of mission performance and a full model of all significant noise sources in the measurement – using a list of potential ARIEL targets that incorporates the latest available exoplanet statistics. The conclusion at the end of the Phase A study, is that ARIEL – in line with the stated mission objectives – will be able to observe about 1000 exoplanets depending on the details of the adopted survey strategy, thus confirming the feasibility of the main science objectives.Peer reviewedFinal Published versio

Hsa-mir183/EGR1-mediated regulation of E2F1 is required for CML stem/progenitor cell survival

Chronic myeloid leukemia (CML) stem/progenitor cells (SPC) express a transcriptional program characteristic of proliferation, yet can achieve and maintain quiescence. Understanding the mechanisms by which leukemic SPC maintain quiescence will help to clarify how they persist during long-term targeted treatment. We have identified a novel BCR-ABL1 protein kinase dependent pathway mediated by the up-regulation of hsa-mir183, the down-regulation of its direct target EGR1 and, as a consequence, up-regulation of E2F1. We show here that inhibition of hsa-mir183 reduced proliferation and impaired colony formation of CML SPC. Downstream of this, inhibition of E2F1 also reduced proliferation of CML SPC, leading to p53-mediated apoptosis. In addition, we demonstrate that E2F1 plays a pivotal role in regulating CML SPC proliferation status. Thus, for the first time, we highlight the mechanism of hsa-mir183/EGR1-mediated E2F1 regulation and demonstrate this axis as a novel, critical factor for CML SPC survival, offering new insights into leukemic stem cell eradication

HADES RV Programme with HARPS-N at TNG. XIII. A sub-Neptune around the M dwarf GJ 720 A

Context. The high number of super-Earth and Earth-like planets in the habitable zone detected around M-dwarf stars in recent years has revealed these stellar objects to be the key to planetary radial velocity (RV) searches. Aims: Using the HARPS-N spectrograph within The HArps-n red Dwarf Exoplanet Survey (HADES) we have reached the precision needed to detect small planets with a few Earth masses using the spectroscopic radial velocity technique. HADES is mainly focused on the M-dwarf population of the northern hemisphere. Methods: We obtained 138 HARPS-N RV measurements between 2013 May and 2020 September of GJ 720 A, classified as an M0.5 V star located at a distance of 15.56 pc. To characterize the stellar variability and to distinguish the periodic variation due to the Keplerian signals from those related to stellar activity, the HARPS-N spectroscopic activity indicators and the simultaneous photometric observations with the APACHE and EXORAP transit surveys were analyzed. We also took advantage of TESS, MEarth, and SuperWASP photometric surveys. The combined analysis of HARPS-N RVs and activity indicators let us address the nature of the periodic signals. The final model and the orbital planetary parameters were obtained by simultaneously fitting the stellar variability and the Keplerian signal using a Gaussian process regression and following a Bayesian criterion. Results: The HARPS-N RV periodic signals around 40 days and 100 days have counterparts at the same frequencies in HARPS-N activity indicators and photometric light curves. We thus attribute these periodicities to stellar activity; the first period is likely associated with the stellar rotation. GJ 720 A shows the most significant signal at 19.466 ± 0.005 days with no counterparts in any stellar activity indices. We hence ascribe this RV signal, having a semi-amplitude of 4.72 ± 0.27 m s−1, to the presence of a sub-Neptune mass planet. The planet GJ 720 Ab has a minimum mass of 13.64 ± 0.79 M⊕, it is in circular orbit at 0.119 ± 0.002 AU from its parent star, and lies inside the inner boundary of the habitable zone around its parent star. Based on observations collected at the Italian Telescopio Nazionale Galileo (TNG), operated on the island of La Palma by the Fundación Galileo Galilei of the INAF (Istituto Nazionale di Astrofisica) at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias, in the framework of the HArps-n red Dwarf Exoplanet Survey (HADES)

TOI-4010: A System of Three Large Short-Period Planets With a Massive Long-Period Companion

We report the confirmation of three exoplanets transiting TOI-4010 (TIC-352682207), a metal-rich K dwarf observed by TESS in Sectors 24, 25, 52, and 58. We confirm these planets with HARPS-N radial velocity observations and measure their masses with 8 - 12% precision. TOI-4010 b is a sub-Neptune ($P = 1.3$ days, $R_{p} = 3.02_{-0.08}^{+0.08}~R_{\oplus}$, $M_{p} = 11.00_{-1.27}^{+1.29}~M_{\oplus}$) in the hot Neptune desert, and is one of the few such planets with known companions. Meanwhile, TOI-4010 c ($P = 5.4$ days, $R_{p} = 5.93_{-0.12}^{+0.11}~R_{\oplus}$, $M_{p} = 20.31_{-2.11}^{+2.13}~M_{\oplus}$) and TOI-4010 d ($P = 14.7$ days, $R_{p} = 6.18_{-0.14}^{+0.15}~R_{\oplus}$, $M_{p} = 38.15_{-3.22}^{+3.27}~M_{\oplus}$) are similarly-sized sub-Saturns on short-period orbits. Radial velocity observations also reveal a super-Jupiter-mass companion called TOI-4010 e in a long-period, eccentric orbit ($P \sim 762$ days and $e \sim 0.26$ based on available observations). TOI-4010 is one of the few systems with multiple short-period sub-Saturns to be discovered so far.Comment: 26 pages, 16 figures, published in A

Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells

e Glasgow and Manchester Experimental Cancer Medicine Centres (ECMC), which are funded by CR-UK and the Chief Scientist’s Office (Scotland). We acknowledge the funders who have contributed to this work: MRC stratified medicine infrastructure award (A.D.W.), CR-UK C11074/A11008 (F.P., L.E.M.H., T.L.H., A.D.W.); LLR08071 (S.A.A., E.C.); LLR11017 (M.C.); SCD/04 (M.C.); LLR13035 (S.A.A., K.D., A.D.W., and A.P.); LLR14005 (M.T.S., D.V.); KKL690 (L.E.P.); KKL698 (P.B.); LLR08004 (A.D.W., A.P. and A.J.W.); MRC CiC (M.E.D.); The Howat Foundation (FACS support); Friends of Paul O’Gorman (K.D. and FACS support); ELF 67954 (S.A.A.); BSH start up fund (S.A.A.); MR/K014854/1 (K.D.)