Educational Background as a Factor of National Welfare Boosting

The article presents the identifying the relationship between the level of education and the level of income in the national economy. As the title implies the article describes the education as a factor of accelerating economic growth: the concept of human capital. Data are given about the educational factor in the economy of developed countries. The article gives the analysis of educational markets in Russia and its impact on the welfare of the population. It is dealt with the state system of higher education in Russia. The main problems of higher education were identified. Recommendations are given for solving the main problems of the higher education system. This article presents such data as indexes of the educational level of the world countries (20 countries), a ranking of countries and territories according to the size of GNI per capita, the relationship between the level of education and the level of income across regions, the relationship between the level of education and socio-economic development of the region (correlation of indicators of socio-economic development of the region and the proportion of people who have vocational education)

Assessment of Students’ Well-Being Condition in Higher Educational Institutions

The article presents the parameters of the welfare of students during their education in a higher school. It is dealt with features of higher education in Russia. Data are given about the surveys regarding students vision of their future well-being. It is formulated the problem of economic security of the University during the work with students. The article deals with conditions for securing economic well-being of the student. We believe that the state of well-being of the student is one of the basic conditions for excellence. Upon reaching the state of personal well-being of the student more conscious approach to the development of the educational process, respectively increase the percentage of mastering the curriculum. Correspondingly, according to the results of such training the student is the most competitive in the labor market. We highlight several factors that determine the state of well-being of the person that may affect the student's study: financial, social, physiological, psychological, emotional

Project Implementation of Corporate Information Systems (ERP and MES) as a Guarantee for Increasing the Operational Efficiency of the Enterprise

This article delves into the intricacies of implementing corporate information systems, such as Enterprise Resource Planning (ERP) and Manufacturing Execution System (MES). It has been established that the implementation of ERP and MES ensures increased operational efficiency of the enterprise by automating various processes. Additionally, the MES system controls multiple production stages, from raw material input to finished product shipment, thereby reducing errors and increasing task execution speed. ERP and MES also facilitate data and information consistency between different departments, providing all levels of management access to the same company information, streamlining the decision-making process. Furthermore, ERP allows for the collection of data on finance, personnel, logistics, and production in one system, making the planning and decision-making process simpler. The MES system can be used to determine task execution time and distribute it among workers based on their skills and abilities. Lastly, ERP and MES enable companies to prioritize tasks, control their execution, automate processes, improve task execution quality and speed, and ensure data and information consistency between different departments. The article discusses the importance of corporate information systems (CIS) in modern companies with a priority of maintaining a competitive position. The key components of such a system are enterprise resource planning (ERP) and manufacturing execution systems (MES), which ensure the integrity, accuracy, and speed of data exchange between all company units. Implementing ERP and MES is a guarantee of increasing the company's operational efficiency in complex production conditions. CIS help companies ensure data and information unity between different departments, enabling quick and efficient decision-making processes.У статті досліджено особливості проєктного впровадження корпоративних інформаційних систем, таких як ERP (Enterprise Resource Planning) та MES (Manufacturing execution system). Встановлено, що впровадження корпоративних інформаційних систем (ERP та MES) є гарантією підвищення операційної ефективності підприємства, оскільки дозволяє автоматизувати багато процесів на підприємстві. З’ясовано, що система MES дозволяє контролювати різні етапи виробництва, починаючи від входу сировини і закінчуючи відвантаженням готової продукції, що знижує кількість помилок та підвищує швидкість виконання завдань. Встановлено, що ERP та MES допомагають забезпечити єдність даних та інформації між різними департаментами, що дозволяє всім рівням управління мати доступ до однакової інформації про діяльність підприємства, тим самим роблячи процес прийняття рішень швидким та ефективним. Визначено, що ERP дозволяє збирати дані про фінанси, кадри, логістику та виробництво в одній системі, що спрощує процес планування та прийняття рішень. Сформульовано, що за допомогою системи MES можна визначити час, необхідний для виконання певного завдання та розподілити його між робітниками відповідно до їхніх навичок та здібностей. Доведено, що ERP та MES дозволяють підприємствам визначати пріоритетність завдань та контролювати їх виконання, допомагають підприємствам автоматизувати процеси, покращувати якість та швидкість виконання завдань, забезпечувати єдність даних та інформації між різними департаментами, та контролювати виконання завдань

Current status of the temperature and humidity regime of the troposphere in the Siberian sector in different circulation periods

The paper studies the long-term dynamics of air temperature and relative humidity anomaly indices in the surface layer and at different levels of the troposphere in Siberia and neighboring regions (European and Far Eastern sectors). As the main cause of the observed variations in climatic parameters we considered circulation factors, which were taken into account using the typification of macrocirculation processes proposed by B.L. Dzerdzeevsky. Seasonal differences were revealed in the distribution of anomaly indices and the area occupied by anomalies of different signs of annual and monthly mean temperature and relative air humidity, which are most pronounced during circulation periods of increased duration of meridional northern processes in the Siberian sector and in the Northern Hemisphere as a whole. The highest rates of change in the temperature regime in the Siberian sector over recent decades have been observed at the level of the isobaric surface AT–700 hPa (3 km), which affects the advective-dynamic factors of surface cyclo- and frontogenesis, as well as the processes of cloud formation and precipitation. In general, an increase in the heat content of the lower and middle troposphere and a decrease in the relative moisture content near the tropopause can be accompanied by an increase in the amount of the potential energy and convective instability energy reserves and can lead to an increase in climate risks in the Siberian sector

Excellent Response to OnabotulinumtoxinA: Different Definitions, Different Predictors

The identification of patients who can benefit the most from the available preventive treatments is important in chronic migraine. We explored the rate of excellent responders to onabotulinumtoxinA in a multicenter European study and explored the predictors of such response, according to different definitions. A pooled analysis on chronic migraineurs treated with onabotulinumtoxinA and followed-up for, at least, 9 months was performed. Excellent responders were defined either as patients with a ≥75% decrease in monthly headache days (percent-based excellent responders) or as patients with <4 monthly headache days (frequency-based excellent responders). The characteristics of excellent responders at the baseline were compared with the ones of patients with a <30% decrease in monthly headache days. Percent-based excellent responders represented about 10% of the sample, whilst frequency-based excellent responders were about 5% of the sample. Compared with non-responders, percent-based excellent responders had a higher prevalence of medication overuse and a higher excellent response rate even after the 1st and the 2nd injection. Females were less like to be frequency-based excellent responders. Chronic migraine sufferers without medication overuse and of female sex may find fewer benefits with onabotulinumtoxinA. Additionally, the excellent response status is identifiable after the first cycle

Comparison of the protein-coding genomes of three deep-sea, sulfur-oxidising bacteria: “Candidatus Ruthia magnifica”, “Candidatus Vesicomyosocius okutanii” and Thiomicrospira crunogena

Abstract Objective “ Candidatus Ruthia magnifica”, “Candidatus Vesicomyosocius okutanii” and Thiomicrospira crunogena are all sulfur-oxidising bacteria found in deep-sea vent environments. Recent research suggests that the two symbiotic organisms, “Candidatus R. magnifica” and “Candidatus V. okutanii”, may share common ancestry with the autonomously living species T. crunogena. We used comparative genomics to examine the genome-wide protein-coding content of all three species to explore their similarities. In particular, we used the OrthoMCL algorithm to sort proteins into groups of putative orthologs on the basis of sequence similarity. Results The OrthoMCL inflation parameter was tuned using biological criteria. Using the tuned value, OrthoMCL delimited 1070 protein groups. 63.5% of these groups contained one protein from each species. Two groups contained duplicate protein copies from all three species. 123 groups were unique to T. crunogena and ten groups included multiple copies of T. crunogena proteins but only single copies from the other species. “Candidatus R. magnifica” had one unique group, and had multiple copies in one group where the other species had a single copy. There were no groups unique to “Candidatus V. okutanii”, and no groups in which there were multiple “Candidatus V. okutanii” proteins but only single proteins from the other species. Results align with previous suggestions that all three species share a common ancestor. However this is not definitive evidence to make taxonomic conclusions and the possibility of horizontal gene transfer was not investigated. Methodologically, the tuning of the OrthoMCL inflation parameter using biological criteria provides further methods to refine the OrthoMCL procedure

One origin for metallo-β-lactamase activity, or two? An investigation assessing a diverse set of reconstructed ancestral sequences based on a sample of phylogenetic trees

This work was supported by BBSRC (grant BB/F016778/1)Bacteria use metallo-β-lactamase enzymes to hydrolyse lactam rings found in many antibiotics, rendering them ineffective. Metallo-β-lactamase activity is thought to be polyphyletic, having arisen on more than one occasion within a single functionally diverse homologous superfamily. Since discovery of multiple origins of enzymatic activity conferring antibiotic resistance has broad implications for the continued clinical use of antibiotics, we test the hypothesis of polyphyly further; if lactamase function has arisen twice independently, the most recent common ancestor (MRCA) is not expected to possess lactam-hydrolysing activity. Two major problems present themselves. Firstly, even with a perfectly known phylogeny, ancestral sequence reconstruction is error prone. Secondly, the phylogeny is not known, and in fact reconstructing a single, unambiguous phylogeny for the superfamily has proven impossible. To obtain a more statistical view of the strength of evidence for or against MRCA lactamase function, we reconstructed a sample of 98 MRCAs of the metallo-β-lactamases, each based on a different tree in a bootstrap sample of reconstructed phylogenies. InterPro sequence signatures and homology modelling were then used to assess our sample of MRCAs for lactamase functionality. Only 5 % of these models conform to our criteria for metallo-β-lactamase functionality, suggesting that the ancestor was unlikely to have been a metallo-β-lactamase. On the other hand, given that ancestral proteins may have had metallo-β-lactamase functionality with variation in sequence and structural properties compared with extant enzymes, our criteria are conservative, estimating a lower bound of evidence for metallo-β-lactamase functionality but not an upper bound.Publisher PDFPeer reviewe