Antiproton-deuteron annihilation at low energies

Recent experimental studies of the antiproton-deuteron system at low energies have shown that the imaginary part of the antiproton-deuteron scattering length is smaller than the antiproton-proton one. Two- and three-body systems with strong annihilation are investigated and a mechanism explaining this unexpected relation between the imaginary parts of the scattering lengths is proposed.Comment: 6 pages, 3 figures, to be published in The European Physical Journal

Effects of econometric and activity analysis derived supply curves on Canadian sawmilling industry market forecasts

This study utilizes the Timber Assessment Market Model (TAMM) to examine the differences in Canadian softwood lumber market forecasts arising from econometric versus activity analysis supply curves. A restricted profit function approach is applied to three lumber producing regions using the most recent data available on costs, prices, and output to estimate the econometric supply curve along with factor demands. The corresponding own- and cross-price elasticities along with the elasticities of substitution are estimated and compared to past studies. An activity analysis supply curve is presented utilizing two production technologies. Market forecasts for the period 1996- 2005 are estimated via the TAMM model. A comparison of TAMM solutions for a base case and three exogenous shock scenarios is presented. Similar price and quantity values are obtained in the historic period, while the activity analysis provide a much more volatile reaction to exogenous stimuli

The Background and Outlook of Students Taking Elementary Botany at Iowa Wesleyan College

Does it help a college student taking botany to have had a course in high school biology? Why are you taking botany? That was one of the questions asked a class of forty-two students at Iowa Wesleyan College during their first class meeting of elementary Botany in September of 947. Many indicated that they were taking it to fulfill their eight hour science requirement for graduation, and some of these indicated interest in nature and biology. Twelve out of the forty-two were definitely biology majors or minors

A proteomics approach to the study of bleomycin- induced lung fibrosis

Idiopathic pulmonary fibrosis (IPF) is the most severe lung fibrotic form and very few pharmacological therapies are available at present. Key events in the onset of the disease are the activation of fibroblasts to myofibroblasts and the production and release of extracellular matrix (ECM) and molecular factors. Primary murine lung fibroblasts were isolated and their activation induced by Bleomycin (BLM) treatment. Extracellular Vesicles (EV) were isolated and protein extracted. Released soluble proteins (Secretome) and EV-derived proteins were reduced, alkylated and trypsin digested. A nano-LC-MS/MS SWATHTM approach was used for the proteomics analyses. Specific proteins with a putative role in the transition from physiological to fibrotic conditions, such as several matrix metalloproteinases (MMPs), osteopontin (OPN), chitinase-3-like protein1 (CHI3L1) and CD44 resulted differentially released from BLM-treated fibroblasts as compared with untreated lung fibroblasts. Our results provide further understanding of the pathophysiological features of lung fibrosis, and suggest specific target for pharmacological treatments

Fluid observers and tilting cosmology

We study perfect fluid cosmological models with a constant equation of state parameter $\gamma$ in which there are two naturally defined time-like congruences, a geometrically defined geodesic congruence and a non-geodesic fluid congruence. We establish an appropriate set of boost formulae relating the physical variables, and consequently the observed quantities, in the two frames. We study expanding spatially homogeneous tilted perfect fluid models, with an emphasis on future evolution with extreme tilt. We show that for ultra-radiative equations of state (i.e., $\gamma>4/3$), generically the tilt becomes extreme at late times and the fluid observers will reach infinite expansion within a finite proper time and experience a singularity similar to that of the big rip. In addition, we show that for sub-radiative equations of state (i.e., $\gamma < 4/3$), the tilt can become extreme at late times and give rise to an effective quintessential equation of state. To establish the connection with phantom cosmology and quintessence, we calculate the effective equation of state in the models under consideration and we determine the future asymptotic behaviour of the tilting models in the fluid frame variables using the boost formulae. We also discuss spatially inhomogeneous models and tilting spatially homogeneous models with a cosmological constant

Pathophysiology of aniridia-associated keratopathy: Developmental aspects and unanswered questions

Aniridia, a rare congenital disease, is often characterized by a progressive, pronounced limbal insufficiency and ocular surface pathology termed aniridia-associated keratopathy (AAK). Due to the characteristics of AAK and its bilateral nature, clinical management is challenging and complicated by the multiple coexisting ocular and systemic morbidities in aniridia. Although it is primarily assumed that AAK originates from a congenital limbal stem cell deficiency, in recent years AAK and its pathogenesis has been questioned in the light of new evidence and a refined understanding of ocular development and the biology of limbal stem cells (LSCs) and their niche. Here, by consolidating and comparing the latest clinical and preclinical evidence, we discuss key unanswered questions regarding ocular developmental aspects crucial to AAK. We also highlight hypotheses on the potential role of LSCs and the ocular surface microenvironment in AAK. The insights thus gained lead to a greater appreciation for the role of developmental and cellular processes in the emergence of AAK. They also highlight areas for future research to enable a deeper understanding of aniridia, and thereby the potential to develop new treatments for this rare but blinding ocular surface disease