The pattern of growth hormone secretion during the menstrual cycle in normal and depressed women

Objective Major depression is associated to altered hypothalamic pituitary function. Stress is linked to elevated cortisol as well as menstrual cycle disturbance; however, there is no known relationship between depression and menstrual cycle disruption. The aim of this study was to investigate changes of growth hormone (GH) secretion during the menstrual cycle in normal and depressed women. Design Case-control study. Patients and methods Nineteen women affected with depression and 24 normal controls were included. The two groups had comparable body mass index (BMI), and age (29·4 ±9·8 vs. 28·6 ± 9·7 years). Nine depressed and 10 controls were studied in the follicular phase, while 10 depressed and 14 controls were studied in the luteal phase of the cycle. GH was sampled every 10 min for 24 h, and the data were analysed by the cluster pulse detection method. Results There was no difference in 24-h mean GH concentrations between depressed and control subjects (P =0·93), even after accounting for menstrual cycle phase (P = 0·38). GH pulse frequency was higher during the follicular phase of the cycle (P =0·032), and nocturnal GH was higher in the follicular phase of the cycle (P =0·05, and after adjusting for 24-h GH, P= 0·0138) regardless of whether thesubjects were depressed or healthy. Conclusions In studies of GH secretion in women with or without depression, it is necessary to control for the phase of menstrual cycle.NIMH MH 50030 NICHD K12HD01438Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/49486/2/KasaVubuYoung.pd

Children’s space in a city undergoing densification : A study of open space per child on preschools in the urban locality of Umeå

This study aims to describe and analyze changes over time in the degree of relative crowding in preschools within the urban area of a medium-sized city in the northern part of Sweden – and does so by examining the size of the available open space per child. Further, this work explores the spatial variation of open space dimensioning in relation to the urban center in order to decide whether shrinking of children’s open space should be considered to be limited to the major metropolitan areas of Sweden. With the basis in an assumption of increasing competition over land as a consequence of neoliberal governance and densification as strategies to promote urban growth, it’s hypothesized from recent literature that these ambitions increasingly risk confining children’s right to adequate areas of open space for outdoor play. Using a combination of quantitative approaches of analysis, with the use of regression analysis the study concluded that the coefficient of the independent variable Building age is positive, and therefore matches the expected direction. However, no statistically significant linear relationship was observed even with the use of relevant variables – highlighting a complex relationship surrounding the understanding and prediction of land use in general and urban open space in particular. A comparison of mean values using grouping based on both the aspect of time and centrality found that preschools built after 1998 generally contains 0,85 m2 larger open space per child than those built before 1987, whereas preschools within the urban center had 6,18 m2 larger open space per child than those located in more peripheral locations. When controlling for the share of preschools that undercuts and exceeds the recommendations related to dimensioning of open space communicated by the Swedish National Board of Housing, Building and Planning, units within the city center was found to meet these recommendations to a greater extent. Preschools built after 1998 seem to be more prevalent among units that undercuts the said recommendations. The results call for further research within this field of study in order to determine whether or not children’s shrinking open space can be limited to be a phenomenon encompassing solely major metropolitan areas.

Fourier Domain Optical Coherence Microscopy with Extended Depth of Field

Fourier Domain Optical Coherence Tomography (FDOCT) is a high speed biomedical imaging modality which extracts the sample structure in depth. The axial resolution is given by the coherence length of the employed light source. The lateral resolution on the other hand is determined by the numerical aperture (NA) of the objective. The parallel detection of the depth information has the drawback of loosing transverse resolution along the optical axis, limiting the depth of field (DOF) and the use of FDOCT in the field of microscopy. The principle idea to overcome this problem is to illuminate the sample with a cylindrically symmetric interference pattern. Such Bessel beam illumination creates a laterally highly confined needle extending several 100μm along the optical axis in depth