Boris Bastian and colleagues present a refined morphological classification of primary melanomas that can be used to improve existing melanoma classifications by defining genetically homogeneous subgroups

Bastian, Boris C

Bauer, Juergen

Fridlyand, Jane

Garbe, Claus

Lasithiotakis, Konstantin

Pinkel, Daniel

Viros, Amaya

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PLoS Medicine

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A new American Joint Committee on Cancer staging system for cutaneous melanoma.

A unifying concept of malignant melanoma: biologic aspects.

Activating BRAF and N-Ras mutations in sporadic primary melanomas: an inverse association with allelic loss on chromosome 9.

Bagging predictors.

BRAF and NRAS mutations are frequent in nodular melanoma but are not associated with tumor cell proliferation or patient survival.

BRAF mutations in metastatic melanoma: a possible association with clinical outcome. Clin Cancer Res 9: 3362–3368. PLoS Medicine | www.plosmedicine.org

Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization.

Classiﬁcation and regresssion trees.

Classiﬁcation of cutaneous malignant melanoma: a reassessment of histopathologic criteria for the distinction of different types.

Classiﬁcation of melanocytic tumors by DNA copy number changes.

Clinical signiﬁcance of BRAF mutations in metastatic melanoma.

Determinants of BRAF mutations in primary melanomas.

Distinct clinical and pathological features are associated with the BRAF (T1799A(V600E)) mutation in primary melanoma.

Distinct sets of genetic alterations in melanoma.

Gene ampliﬁcations characterize acral melanoma and permit the detection of occult tumor cells in the surrounding skin.

High frequency of BRAF mutations in nevi.

Improvement of overall survival of patients with cutaneous melanoma in Germany, 1976–2001: which factors contributed?

Incidence of BRAF oncogene mutation and clinical relevance for primary cutaneous melanomas.

Integrative genomic analyses identify MITF as a lineage survival oncogene ampliﬁed in malignant melanoma.

Interobserver reproducibility of ulceration assessment in primary cutaneous melanomas.

Lessons from tumor progression: the invasive radial growth phase of melanoma is common, incapable of metastasis, and indolent.

MC1R germline variants confer risk for BRAF-mutant melanoma.

Melanocytic nevi, solar keratoses, and divergent pathways to cutaneous melanoma.

Nodular melanoma is not a distinct entity. Arch Dermatol 139: 387; author reply 387–388.

NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression.

NRAS and BRAF mutations in melanoma tumours in relation to clinical characteristics: a study based on mutation screening by pyrosequencing.

Random forests.

Sarasin A

Somatic activation of KIT in distinct subtypes of melanoma.

Sun exposure and mortality from melanoma.

The classiﬁcation of malignant melanoma and its histologic reporting.

The classiﬁcation of malignant melanoma, its histological reporting and registration: a revision of the 1972 Sydney classiﬁcation.

The clinical diagnosis of malignant melanoma.

The histogenesis and biological behaviour of pimary human malignant melanoma.

The measurement of observer agreement for categorical data.

Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma.

Improving Melanoma Classification by Integrating Genetic and Morphologic Features