Understanding bias in relationships between the food environment and diet quality: The Coronary Artery Risk Development in Young Adults (CARDIA) study

Background The relationship between food environment exposures and diet behaviours is unclear, possibly because the majority of studies ignore potential residual confounding. Methods We used 20 years (1985-1986, 1992-1993 2005-2006) of data from the Coronary Artery Risk Development in Young Adults (CARDIA) study across four US cities (Birmingham, Alabama; Chicago, Illinois; Minneapolis, Minnesota; Oakland, California) and instrumental variables (IV) regression to obtain causal estimates of longitudinal associations between the percentage of neighbourhood food outlets (per total food outlets within 1 km network distance of respondent residence) and an a priori diet quality score, with higher scores indicating higher diet quality. To assess the presence and magnitude of bias related to residual confounding, we compared results from causal models (IV regression) to non-causal models, including ordinary least squares regression, which does not account for residual confounding at all and fixed-effects regression, which only controls for time-invariant unmeasured characteristics. Results The mean diet quality score across follow-up was 63.4 (SD=12.7). A 10% increase in fast food restaurants (relative to full-service restaurants) was associated with a lower diet quality score over time using IV regression (β=-1.01, 95% CI -1.99 to -0.04); estimates were attenuated using non-causal models. The percentage of neighbourhood convenience and grocery stores (relative to supermarkets) was not associated with diet quality in any model, but estimates from non-causal models were similarly attenuated compared with causal models. Conclusion Ignoring residual confounding may generate biased estimated effects of neighbourhood food outlets on diet outcomes and may have contributed to weak findings in the food environment literature

Does unmeasured confounding influence associations between the retail food environment and body mass index over time? The Coronary Artery Risk Development in Young Adults (CARDIA) study

Background: Findings in the observational retail food environment and obesity literature are inconsistent, potentially due to a lack of adjustment for residual confounding. Methods: Using data from the CARDIA study (n ¼ 12 174 person-observations; 6 examinations; 1985-2011) across four US cities (Birmingham, AL; Chicago, IL; Minneapolis, MN; Oakland, CA), we used instrumental-variables (IV) regression to obtain causal estimates of the longitudinal associations between the percentage of neighbourhood food stores or restaurants (per total food outlets within 1 km network distance of respondent residence) with body mass index (BMI), adjusting for individual-level socio-demographics, health behaviours, city, year, total food outlets and market-level prices. To determine the presence and extent of bias, we compared the magnitude and direction of results with ordinary least squares (OLS) and random effects (RE) regression, which do not control for residual confounding, and with fixed effects (FE) regression, which does not control for time-varying residual confounding. Results: Relative to neighbourhood supermarkets (which tend to be larger and have healthier options than grocery stores), a higher percentage of grocery stores [mean-¼ 53.4%; standard deviation (SD) ¼ 31.8%] was positively associated with BMI [b ¼ 0.05; 95% confidence interval (CI) ¼ 0.01, 0.10] using IV regression. However, associations were negligible or null using OLS (b ¼ 0.001; 95% CI ¼ 0.01, 0.01), RE (b ¼ 0.003; 95% CI ¼ 0.01, 0.0001) and FE (b ¼ 0.003; 95% CI ¼ 0.01, 0.0002) regression. Neighbourhood convenience stores and fast-food restaurants were not associated with BMI in any model. Conclusions: Longitudinal associations between neighbourhood food outlets and BMI were greater in magnitude using a causal model, suggesting that weak findings in the literature may be due to residual confounding

Cooperative AUV Navigation using a Single Maneuvering Surface Craft

In this paper we describe the experimental implementation of an online algorithm for cooperative localization of submerged autonomous underwater vehicles (AUVs) supported by an autonomous surface craft. Maintaining accurate localization of an AUV is difficult because electronic signals, such as GPS, are highly attenuated by water. The usual solution to the problem is to utilize expensive navigation sensors to slow the rate of dead-reckoning divergence. We investigate an alternative approach that utilizes the position information of a surface vehicle to bound the error and uncertainty of the on-board position estimates of a low-cost AUV. This approach uses the Woods Hole Oceanographic Institution (WHOI) acoustic modem to exchange vehicle location estimates while simultaneously estimating inter-vehicle range. A study of the system observability is presented so as to motivate both the choice of filtering approach and surface vehicle path planning. The first contribution of this paper is to the presentation of an experiment in which an extended Kalman filter (EKF) implementation of the concept ran online on-board an OceanServer Iver2 AUV while supported by an autonomous surface vehicle moving adaptively. The second contribution of this paper is to provide a quantitative performance comparison of three estimators: particle filtering (PF), non-linear least-squares optimization (NLS), and the EKF for a mission using three autonomous surface craft (two operating in the AUV role). Our results indicate that the PF and NLS estimators outperform the EKF, with NLS providing the best performance.United States. Office of Naval Research (Grant N000140711102)United States. Office of Naval Research. Multidisciplinary University Research InitiativeSingapore. National Research FoundationSingapore-MIT Alliance for Research and Technology. Center for Environmental Sensing and Monitorin

Comparison and Implementation of a Rigid and a Flexible Multibody Planetary Gearbox Model

We propose algorithms for developing (1) a rigid (constrained) and (2) a flexible planetary gearbox model. The two methods are compared against each other and advantages/disadvantages of each method are discussed. The rigid model (1) has gear tooth reaction forces expressed by Lagrange multipliers. The flexible approach (2) is being compared with the gear tooth forces from the rigid approach, first without damping and second the influence of damping is examined. Variable stiffness as a function of base circle arc length is implemented in the flexible approach such that it handles the realistic switch between one and two gear teeth in mesh. The final results are from modelling the planetary gearbox in a 500 kW wind turbine which we also described in Jørgensen et.al (2013)

Observation of low-lying resonances in the quasicontinuum of 195,196Pt and enhanced astrophysical reaction rates

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Chronology of Dune Development in the White River Badlands, Northern Great Plains, USA

Aeolian dune field chronologies provide important information on drought history on the Great Plains. The White River Badlands (WRB) dunes are located approximately 60 km north of the Nebraska Sand Hills (NSH), in the western section of the northern Great Plains. Clifftop dunes, sand sheets, and stabilized northwest-southeast trending parabolic dunes are found on upland mesas and buttes, locally called tables. The result of this study is a dune stabilization history determined from samples collected from stratigraphic exposures and dune crests. Thirty-seven OSL ages, from this and previous investigations, show three periods of dune activity: 1) ∼21,000 years ago to 12,000 years ago (a), 2) ∼9 to 6 ka, and 3) post-700 a. Stratigraphic exposures and low-relief dune forms preserve evidence of late Pleistocene and middle Holocene dune development, while high-relief dune crests preserve evidence of late Holocene dune development. Results of 12 OSL ages from the most recent dune activation event indicate that Medieval Climate Anomaly (MCA) droughts and Little Ice Age (LIA) droughts caused dune reactivation on the tables. Dune reactivation was accompanied by other drought-driven geomorphological responses in the WRB, including fluvial incision of the prairie and formation of sod tables. Regional significance of the MCA and LIA droughts is supported by similarities in the aeolian chronologies of the NSH at 700–600 a and some western Great Plains dune fields at 420–210 a. Aerial photographs of the WRB show little activity during the Dust Bowl droughts of the 1930s

Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology

Publisher Copyright: © 2022, The Author(s).Back pain is a common and debilitating disorder with largely unknown underlying biology. Here we report a genome-wide association study of back pain using diagnoses assigned in clinical practice; dorsalgia (119,100 cases, 909,847 controls) and intervertebral disc disorder (IDD) (58,854 cases, 922,958 controls). We identify 41 variants at 33 loci. The most significant association (ORIDD = 0.92, P = 1.6 × 10−39; ORdorsalgia = 0.92, P = 7.2 × 10−15) is with a 3’UTR variant (rs1871452-T) in CHST3, encoding a sulfotransferase enzyme expressed in intervertebral discs. The largest effects on IDD are conferred by rare (MAF = 0.07 − 0.32%) loss-of-function (LoF) variants in SLC13A1, encoding a sodium-sulfate co-transporter (LoF burden OR = 1.44, P = 3.1 × 10−11); variants that also associate with reduced serum sulfate. Genes implicated by this study are involved in cartilage and bone biology, as well as neurological and inflammatory processes.Peer reviewe

Establishing tephrostratigraphic frameworks to aid the study of abrupt climatic and glacial transitions: a case study of the Last Glacial-Interglacial Transition in the British Isles (c. 16-8 ka BP)

Distally dispersed tephra layers have become an important tool in the investigation of palaeoenvironmental and archaeological records across the globe. They offer possibilities for the synchronisation and improved chronological control in those records to which they can be traced and hence contribute to an improved understanding of the pattern and timing of environmental and archaeological change during periods of rapid climatic adjustment. However, their use as robust isochronous markers for synchronising records is frequently compromised by uncertainties relating to stratigraphical context, precise chronology and chemical composition. Here we collate and review the tephrostratigraphical information dating to the Last Glacial-Interglacial Transition (LGIT; c. 16-8 ka BP) in the British Isles based on published and unpublished records obtained from 54 sites. Based on details of their stratigraphic position, chronology and chemical composition, we propose that 26 individual eruption events may be represented in this collective record which spans the LGIT. The great majority of these eruptives can be traced in origin to Iceland, but we also report on the recent discoveries of ultra-distal tephra from the North American Cascades range, including for the first time the Mount St Helens J Tephra at a site in southern Ireland. These particular ultra-distal discoveries have resulted from a reinterpretation of older data, demonstrating the potential importance of ‘unknown’ analyses in older tephra datasets. The outcome of this review is a comprehensive but provisional tephrostratigraphic framework for the LGIT in the British Isles, which helps to focus future research on parts of the scheme that are in need of further development or testing. The results, therefore, make an important contribution to the wider European tephrostratigraphic framework, while adding new discoveries of transcontinental isochronous tephra markers