Determination of recrystallisation phenomenon in type 316 stainless steel VIM-VAR ingots during cogging operations

This study is focused on understanding the effects of key process parameters on the onset of recrystallisation of coarse, elongated, and dendritic grains of the as-cast microstructure during ingot-to-billet conversion, consisting of successive cogging, upsetting, and reheating operations, in type 316 austenitic stainless steel. The microstructural characteristics of the initial as-cast ingot (e.g., size, orientation and morphology of grains), and the complex thermo-mechanical path have significant impact on recrystallisation behaviours, which make the existing material models inefficient of precise microstructure prediction. These investigations aim at exploring the recrystallisation mechanisms and their dependency on the forging process parameters. Cogging trails were conducted on VIM-VAR stainless steel ingots and microstructural observations were made to identify the recrystallisation mechanisms. Finite element simulations coupled with constitutive material models were developed in parallel, to enable microstructurally informed prediction of the cogging process. Thus, static and discontinuous dynamic recrystallisations occur in succession after reaching a threshold level of deformation during cogging. Grain growth occurred in the statically recrystallised grains during reheating. The importance of the reheating and the associated static recrystallisation on the efficiency of the billet conversion process in terms of grain refinement is thus highlighted

SPHERE IRDIS and IFS astrometric strategy and calibration

We present the current results of the astrometric characterization of the VLT planet finder SPHERE over 2 years of on-sky operations. We first describe the criteria for the selection of the astrometric fields used for calibrating the science data: binaries, multiple systems, and stellar clusters. The analysis includes measurements of the pixel scale and the position angle with respect to the North for both near-infrared subsystems, the camera IRDIS and the integral field spectrometer IFS, as well as the distortion for the IRDIS camera. The IRDIS distortion is shown to be dominated by an anamorphism of 0.60+/-0.02% between the horizontal and vertical directions of the detector, i.e. 6 mas at 1". The anamorphism is produced by the cylindrical mirrors in the common path structure hence common to all three SPHERE science subsystems (IRDIS, IFS, and ZIMPOL), except for the relative orientation of their field of view. The current estimates of the pixel scale and North angle for IRDIS are 12.255+/-0.009 milliarcseconds/pixel for H2 coronagraphic images and -1.75+/-0.08 deg. Analyses of the IFS data indicate a pixel scale of 7.46+/-0.02 milliarcseconds/pixel and a North angle of -102.18+/-0.13 deg. We finally discuss plans for providing astrometric calibration to the SPHERE users outside the instrument consortium.Comment: 12 pages, 6 figures, 3 table

Recombination in the Open-Ended Value Landscape of Digital Innovation

Digital innovation introduces a new open-ended value landscape to anyone seeking to generate or capture new value. To understand this landscape, we distinguish between design recombination and use recombination, explore how they play out together, and redirect the attention from products and services toward digital resources. Digital resources serve as building-blocks in digital innovation, and they hold the potential to simultaneously be part of multiple value paths, offered through design recombination and assembled through use recombination. Building on this perspective, we offer the value spaces framework as a tool for better understanding value creation and capture in digital innovation. We illustrate the framework and offer the early contours of a research agenda for information systems researchers

Maternal Exposure to Nitrogen Dioxide, Intake of Methyl Nutrients, and Congenital Heart Defects in Offspring

Nutrients that regulate methylation processes may modify susceptibility to the effects of air pollutants. Data from the National Birth Defects Prevention Study (United States, 1997-2006) were used to estimate associations between maternal exposure to nitrogen dioxide (NO2), dietary intake of methyl nutrients, and the odds of congenital heart defects in offspring. NO2 concentrations, a marker of traffic-related air pollution, averaged across postconception weeks 2-8, were assigned to 6,160 nondiabetic mothers of cases and controls using inverse distance-squared weighting of air monitors within 50 km of maternal residences. Intakes of choline, folate, methionine, and vitamins B6 and B12 were assessed using a food frequency questionnaire. Hierarchical regression models, which accounted for similarities across defects, were constructed, and relative excess risks due to interaction were calculated. Relative to women with the lowest NO2 exposure and high methionine intake, women with the highest NO2 exposure and lowest methionine intake had the greatest odds of offspring with a perimembranous ventricular septal defect (odds ratio = 3.23, 95% confidence interval: 1.74, 6.01; relative excess risk due to interaction = 2.15, 95% confidence interval: 0.39, 3.92). Considerable departure from additivity was not observed for other defects. These results provide modest evidence of interaction between nutrition and NO2 exposure during pregnancy

Common mouse models of tauopathy reflect early but not late human disease

BACKGROUND: Mouse models that overexpress human mutant Tau (P301S and P301L) are commonly used in preclinical studies of Alzheimer’s Disease (AD) and while several drugs showed therapeutic effects in these mice, they were ineffective in humans. This leads to the question to which extent the murine models reflect human Tau pathology on the molecular level. METHODS: We isolated insoluble, aggregated Tau species from two common AD mouse models during different stages of disease and characterized the modification landscape of the aggregated Tau using targeted and untargeted mass spectrometry-based proteomics. The results were compared to human AD and to human patients that suffered from early onset dementia and that carry the P301L Tau mutation. RESULTS: Both mouse models accumulate insoluble Tau species during disease. The Tau aggregation is driven by progressive phosphorylation within the proline rich domain and the C-terminus of the protein. This is reflective of early disease stages of human AD and of the pathology of dementia patients carrying the P301L Tau mutation. However, Tau ubiquitination and acetylation, which are important to late-stage human AD are not represented in the mouse models. CONCLUSION: AD mouse models that overexpress human Tau using risk mutations are a suitable tool for testing drug candidates that aim to intervene in the early formation of insoluble Tau species promoted by increased phosphorylation of Tau. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13024-023-00601-y

The B-Star Exoplanet Abundance Study: a co-moving 16-25 Mjup companion to the young binary system HIP 79098

Wide low-mass substellar companions are known to be very rare among low-mass stars, but appear to become increasingly common with increasing stellar mass. However, B-type stars, which are the most massive stars within ~150 pc of the Sun, have not yet been examined to the same extent as AFGKM-type stars in that regard. In order to address this issue, we launched the ongoing B-star Exoplanet Abundance Study (BEAST) to examine the frequency and properties of planets, brown dwarfs, and disks around B-type stars in the Scorpius-Centaurus (Sco-Cen) association; we also analyzed archival data of B-type stars in Sco-Cen. During this process, we identified a candidate substellar companion to the B9-type spectroscopic binary HIP 79098 AB, which we refer to as HIP 79098 (AB)b. The candidate had been previously reported in the literature, but was classified as a background contaminant on the basis of its peculiar colors. Here we demonstrate that the colors of HIP 79098 (AB)b are consistent with several recently discovered young and low-mass brown dwarfs, including other companions to stars in Sco-Cen. Furthermore, we show unambiguous common proper motion over a 15-year baseline, robustly identifying HIP 79098 (AB)b as a bona fide substellar circumbinary companion at a 345+/-6 AU projected separation to the B9-type stellar pair. With a model-dependent mass of 16-25 Mjup yielding a mass ratio of <1%, HIP 79098 (AB)b joins a growing number of substellar companions with planet-like mass ratios around massive stars. Our observations underline the importance of common proper motion analysis in the identification of physical companionship, and imply that additional companions could potentially remain hidden in the archives of purely photometric surveys.Comment: 9 pages, 6 figures, accepted for publication in A&

BEAST detection of a brown dwarf and a low-mass stellar companion around the young bright B star HIP 81208

Recent observations from B-star Exoplanet Abundance Study (BEAST) have illustrated the existence of sub-stellar companions around very massive stars. In this paper, we present the detection of two lower mass companions to a relatively nearby ($148.7^{+1.5}_{-1.3}$ pc), young ($17^{+3}_{-4}$ Myr), bright (V=$6.632\pm0.006$ mag), $2.58\pm0.06~ M_{\odot}$ B9V star HIP 81208 residing in the Sco-Cen association, using the Spectro-Polarimetric High-contrast Exoplanet REsearch (SPHERE) instrument at the Very Large Telescope (VLT) in Chile. Analysis of the photometry obtained gives mass estimates of $67^{+6}_{-7}~M_J$ for the inner companion and $0.135^{+0.010}_{-0.013}~M_{\odot}$ for the outer companion, indicating the former to be most likely a brown dwarf and the latter to be a low-mass star. The system is compact but unusual, as the orbital planes of the two companions are likely close to orthogonal. The preliminary orbital solutions we derived for the system indicate that the star and the two companions are likely in a Kozai resonance, rendering the system dynamically very interesting for future studies.Comment: 18 pages, 14 figures, 5 tables Accepted for publication in the 10. Planets and planetary systems section of A&

Towards defining reference materials for extracellular vesicle size, concentration, refractive index and epitope abundance

Accurate characterization of extracellular vesicles (EVs) is critical to explore their diagnostic and therapeutic applications. As the EV research field has developed, so too have the techniques used to characterize them. The development of reference materials is required for the standardization of these techniques. This work, initiated from the ISEV 2017 Biomarker Workshop in Birmingham, UK, and with further discussion during the ISEV 2019 Standardization Workshop in Ghent, Belgium, sets out to elucidate which reference materials are required and which are currently available to standardize commonly used analysis platforms for characterizing EV size, concentration, refractive index, and epitope expression. Due to their predominant use, a particular focus is placed on the optical methods nanoparticle tracking analysis and flow cytometry.Comment: 30 pages, 6 figures, 2 table