Survivors, College, and the Law: Challenges in Rewriting Campus Sexual Misconduct Policy

In September 2008, two top University of Iowa officials were fired as a result of the university’s mishandling of a 2007 sexual assault case. A review conducted by an external law firm found many significant flaws in the university’s response and its sexual assault policy. Colleges are rewriting their sexual assault policies to include more precise and/or legal definitions of terms such as sexual misconduct, sexual harassment, consent, and incapacitation. This article examines why it is necessary to have inclusive language in sexual misconduct policies and how campus officials are incorporating victim’s bill of rights, responsibilities, and confidential resources, in order to educate students, staff, and faculty. Looking to recently updated sexual misconduct and assault policies deemed “model” as a basis for reference, this article aims to explore the challenges university officials face in rewriting policy

The Impact of Equity Engagement Evaluating the Impact of Shareholder Engagement in Public Equity Investing

Over the last decade, growing numbers of investors have become increasingly concerned with the environmental and social impact of their investments across asset classes. This trend has recently been driven by new waves of "impact investors" proactively seeking measurable social and environmental impact in addition to financial returns, and by "responsible investors" making commitments to engage on environmental, social, and governance (ESG) issues through initiatives such as the United Nations-backed Principles for Responsible Investment (PRI). At the same time, engaged shareholders have had long-standing experience using "the power of the proxy" and their voices as investors to hold companies accountable for the impacts they have on employees, stakeholders, communities, and ecosystems.While investor interest in shareholder engagement has grown, our understanding of the impacts associated with engagement activities remains largely anecdotal.In 2012, an important study on Total Portfolio Activation provided a new conceptual and analytical framework for investors to pursue environmental and social impact across all asset classes commonly found in a diversified investment portfolio. Building upon the insights of Total Portfolio Activation, the Impact of Equity Engagement (IE2) initiative seeks to deepen our understanding of the nature of impact in one specific asset class—public equities— where investors' engagement activities have generated meaningful social and environmental impacts.Given the large social and environmental footprints of publicly traded corporations and the persistently high allocation to public equities in most investor portfolios, public equity investing presents a major opportunity for impact investing. Yet impact investing, as currently practiced, has concentrated primarily on smallscale direct investments in private equity and debt, where many investors perceive that social and environmental impact can be more readily observed than in publicly traded companies where ownership is intermediated, diluted, and diffused through secondary capital markets.Indeed, the nature of impact within public equity investing remains poorly understood and insufficiently documented. Because of this, many investors may be overlooking readily available opportunities for generating impact within their existing investment portfolios.To address these misperceptions and missed opportunities, the IE2 initiative is developing a more rigorous framework for documenting the impact of engagement within the public equity asset class.

Graduate Colleague Mentorship: Meaningful Connections for Emerging Women in Student Affairs

The Vermont Connection, at its core, is about people who invest in people. As aspiring and practicing student affairs educators, we invest in ourselves, in our students, in our colleagues, and in our research—research that frequently centers on the relationships among these groups of people. We invest because we grew from relationships with those who cared enough to do the same for us. We are the product of myriad connections across time and landscapes, knit together in our common experience in the University of Vermont’s Higher Education and Student Affairs (HESA) program. Intentional connection building is the purpose of HESA’s Graduate Colleague (GC) program, where incoming first-year students are matched with second-year students to assist in the transition to Vermont, the University, and HESA. In the following article, five generations of GCs discuss, through the lens of feminist theory, how our special connection informed and shaped each of our academic experiences, professional development, and voice-finding processes

Protein trafficking, ergosterol biosynthesis and membrane physics impact recombinant protein secretion in Pichia pastoris

Background: The increasing availability of 'omics' databases provide important platforms for yeast engineering strategies since they offer a lot of information on the physiology of the cells under diverse growth conditions, including environmental stresses. Notably, only a few of these approaches have considered a performance under recombinant protein production conditions. Recently, we have identified a beneficial effect of low oxygen availability on the expression of a human Fab fragment in Pichia pastoris. Transcriptional analysis and data mining allowed for the selection of potential targets for strain improvement. A first selection of these candidates has been evaluated as recombinant protein secretion enhancers. Results: Based on previous transcriptomics analyses, we selected 8 genes for co-expression in the P. pastoris strain already secreting a recombinant Fab fragment. Notably, WSC4 (which is involved in trafficking through the ER) has been identified as a novel potential target gene for strain improvement, with up to a 1.2-fold increase of product yield in shake flask cultures. A further transcriptomics-based strategy to modify the yeast secretion system was focused on the ergosterol pathway, an aerobic process strongly affected by oxygen depletion. By specifically partially inhibiting ergosterol synthesis with the antifungal agent fluconazole (inhibiting Erg11p), we tried to mimic the hypoxic conditions, in which the cellular ergosterol content was significantly decreased. This strategy led to an improved Fab yield (2-fold) without impairing cellular growth. Since ergosterol shortage provokes alterations in the plasma membrane composition, an important role of this cellular structure in protein secretion is suggested. This hypothesis was additionally supported by the fact that the addition of non-ionic surfactants also enhanced Fab secretion. Conclusions: The current study presents a systems biotechnology-based strategy for the engineering of the industrially important yeast P. pastoris combining the use of host specific DNA microarray technologies and physiological studies under well defined environmental conditions. Such studies allowed for the identification of novel targets related with protein trafficking and ergosterol biosynthesis for improved recombinant protein production. Nevertheless, further studies will be required to elucidate the precise mechanisms whereby membrane biogenesis and composition impact on protein secretion in P. pastoris

Deep crustal anatexis, magma mixing, and the generation of epizonal plutons in the Southern Rocky Mountains, Colorado

The Never Summer Mountains in north-central Colorado, USA, are cored by two Oligocene, epizonal granitic plutons originally emplaced in the shallow levels of a short-lived (~1 m.y.), small-volume continental magmatic system. The younger Mt. Cumulus stock (28.015 ± 0.012 Ma) is a syenogranite equivalent compositionally to topaz rhyolites. A comparison to the chemical and isotopic composition of crustal xenoliths entrained in nearby Devonian kimberlites demonstrates that the silicic melts parental to the stock were likely derived from anatexis of local Paleoproterozoic, garnet-absent, mafic lower continental crust. In contrast, the older Mt. Richthofen stock is compositionally heterogeneous and ranges from monzodiorite to monzogranite. Major and trace element abundances and Sr, Nd and Pb isotopic ratios in this stock vary regularly with increasing whole rock wt% SiO2. These data suggest that the Mt. Richthofen stock was constructed from mixed mafic and felsic magmas, the former corresponding to lithosphere-derived basaltic magmas similar isotopically to mafic enclaves entrained in the eastern portions of the stock and the latter corresponding to less differentiated versions of the silicic melts parental to the Mt. Cumulus stock. Zircon U–Pb geochronology further reveals that the Mt. Richthofen stock was incrementally emplaced over a time interval from at least 28.975 ± 0.020 to 28.742 ± 0.053 Ma. Magma mixing could have occurred either in situ in the upper crust during basaltic underplating and remelting of an antecedent, incrementally emplaced, silicic intrusive body, or at depth in the lower crust prior to periodic magma ascent and emplacement in the shallow crust. Overall, the two stocks demonstrate that magmatism associated with the Never Summer igneous complex was fundamentally bimodal in composition. Highly silicic anatectic melts of the mafic lower crust and basaltic, mantle-derived magmas were the primary melts in the magma system, with mixing of the two producing intermediate composition magmas such as those from which Mt. Richthofen stock was constructed.National Science Foundation (U.S.) (Grant EAR-0931839

Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity.

Kinesin force generation involves ATP-induced docking of the neck linker (NL) along the motor core. However, the roles of the proposed steps of NL docking, cover-neck bundle (CNB) and asparagine latch (N-latch) formation, during force generation are unclear. Furthermore, the necessity of NL docking for transport of membrane-bound cargo in cells has not been tested. We generated kinesin-1 motors impaired in CNB and/or N-latch formation based on molecular dynamics simulations. The mutant motors displayed reduced force output and inability to stall in optical trap assays but exhibited increased speeds, run lengths, and landing rates under unloaded conditions. NL docking thus enhances force production but at a cost to speed and processivity. In cells, teams of mutant motors were hindered in their ability to drive transport of Golgi elements (high-load cargo) but not peroxisomes (low-load cargo). These results demonstrate that the NL serves as a mechanical element for kinesin-1 transport under physiological conditions

Characteristics of Lightning Within Electrified Snowfall Events Using Total Lightning Measurements

No abstract availabl