1,013 research outputs found
Points of Low Height on Elliptic Curves and Surfaces, I: Elliptic surfaces over P^1 with small d
For each of n=1,2,3 we find the minimal height h^(P) of a nontorsion point P
of an elliptic curve E over C(T) of discriminant degree d=12n (equivalently, of
arithmetic genus n), and exhibit all (E,P) attaining this minimum. The minimal
h^(P) was known to equal 1/30 for n=1 (Oguiso-Shioda) and 11/420 for n=2
(Nishiyama), but the formulas for the general (E,P) were not known, nor was the
fact that these are also the minima for an elliptic curve of discriminant
degree 12n over a function field of any genus. For n=3 both the minimal height
(23/840) and the explicit curves are new. These (E,P) also have the property
that that mP is an integral point (a point of naive height zero) for each
m=1,2,...,M, where M=6,8,9 for n=1,2,3; this, too, is maximal in each of the
three cases.Comment: 15 pages; some lines in the TeX source are commented out with "%" to
meet the 15-page limit for ANTS proceeding
Toxicity of cancer therapy: what the cardiologist needs to know about angiogenesis inhibitors
Clinical outcomes for patients with a wide range of malignancies have improved substantially over the last two decades. Tyrosine kinase inhibitors (TKIs) are potent signalling cascade inhibitors and have been responsible for significant advances in cancer therapy. By inhibiting vascular endothelial growth factor receptor (VEGFR)-mediated tumour blood vessel growth, VEGFR-TKIs have become a mainstay of treatment for a number of solid malignancies. However, the incidence of VEGFR-TKI-associated cardiovascular toxicity is substantial and previously under-recognised. Almost all patients have an acute rise in blood pressure, and the majority develop hypertension. They are associated with the development of left ventricular systolic dysfunction (LVSD), heart failure and myocardial ischaemia and can have effects on myocardial repolarisation. Attention should be given to rigorous baseline assessment of patients prior to commencing VEGFR-TKIs, with careful consideration of baseline cardiovascular risk factors. Baseline blood pressure measurement, ECG and cardiac imaging should be performed routinely. Hypertension management currently follows national guidelines, but there may be a future role forendothelin-1 antagonism in the prevention or treatment of VEGFR-TKI-associated hypertension. VEGFR-TKI-associated LVSD appears to be independent of dose and is reversible. Patients who develop LVSD and heart failure should be managed with conventional heart failure therapies, but the role of prophylactic therapy is yet to be defined. Serial monitoring of left ventricular function and QT interval require better standardisation and coordinated care. Management of these complex patients requires collaborative, cardio-oncology care to allow the true therapeutic potential from cancer treatment while minimising competing cardiovascular effects
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Verified modeling of a low pressure hydrogen plasma generated by electron cyclotron resonance
A self-consistent fluid model has been successfully developed and employed to model an electron cyclotron resonance driven hydrogen plasma at low pressure. This model has enabled key insights to be made on the mutual interaction of microwave propagation, power density, plasma generation, and species transport at conditions where the critical plasma density is exceeded. The model has been verified by two experimental methods. Good agreement with the ion current density and floating potential—as measured by a retarding energy field analyzer—and excellent agreement with the atomic hydrogen density—as measured by two-photon absorption laser induced fluorescence—enables a high level of confidence in the validity of the simulation
On the Relationship between the Uniqueness of the Moonshine Module and Monstrous Moonshine
We consider the relationship between the conjectured uniqueness of the
Moonshine Module, , and Monstrous Moonshine, the genus zero
property of the modular invariance group for each Monster group Thompson
series. We first discuss a family of possible meromorphic orbifold
constructions of based on automorphisms of the Leech
lattice compactified bosonic string. We reproduce the Thompson series for all
51 non-Fricke classes of the Monster group together with a new relationship
between the centralisers of these classes and 51 corresponding Conway group
centralisers (generalising a well-known relationship for 5 such classes).
Assuming that is unique, we then consider meromorphic
orbifoldings of and show that Monstrous Moonshine holds if
and only if the only meromorphic orbifoldings of give
itself or the Leech theory. This constraint on the
meromorphic orbifoldings of therefore relates Monstrous
Moonshine to the uniqueness of in a new way.Comment: 53 pages, PlainTex, DIAS-STP-93-0
Efficient pairing computation with theta functions
The original publication is available at www.springerlink.comInternational audienceIn this paper, we present a new approach based on theta functions to compute Weil and Tate pairings. A benefit of our method, which does not rely on the classical Miller's algorithm, is its generality since it extends to all abelian varieties the classical Weil and Tate pairing formulas. In the case of dimension and abelian varieties our algorithms lead to implementations which are efficient and naturally deterministic. We also introduce symmetric Weil and Tate pairings on Kummer varieties and explain how to compute them efficiently. We exhibit a nice algorithmic compatibility between some algebraic groups quotiented by the action of the automorphism , where the -action can be computed efficiently with a Montgomery ladder type algorithm
Feasibility of Electrified Propulsion for Ultra-Efficient Commercial Aircraft Final Report
MIT, Aurora Flight Sciences, and USC have collaborated to assess the feasibility of electric, hybridelectric, and turbo-electric propulsion for ultra-efficient commercial transportation. The work has drawn on the team expertise in disciplines related to aircraft design, propulsion-airframe integration, electric machines and systems, engineering system design, and optimization. A parametric trade space analysis has been carried out to assess vehicle performance across a range of transport missions and propulsion architectures to establish how electrified propulsion systems scale. An optimization approach to vehicle conceptual design modeling was taken to enable rapid multidisciplinary design space exploration and sensitivity analysis. The results of the analysis indicate vehicle aero-propulsive integration benefits enabled by electrification are required to offset the increased weight and loss associated with the electric system and achieve enhanced performance; the report describes the conceptual configurations than can offer such enhancements. The main contribution of the present work is the definition of electric vehicle design attributes for potential efficiency improvements at different scales. Based on these results, key areas for future research are identified, and extensions to the trade space analysis suitable for higher fidelity electrified commercial aircraft design and analysis have been developed
Single gluino production in the R-parity lepton number violating MSSM at the LHC
We examine the -violating signal of single gluino production
associated with a charged lepton or neutrino at the large hadron collider
(LHC), in the model of R-parity relaxed supersymmetric model. If the parameters
in the supersymmetric interactions are not too small, and the
mass of gluino is considered in the range from several GeV (as the Lightest
Supersymmetric Particle) to 800 GeV, the cross section of the single gluino
production via Drell-Yan processes can be in the order of
femto barn, and that via gluon fusion in the order of femto
barn. If the gluino decay can be well detected in the CERN LHC, this process
provides a prospective way to probe supersymmetry and violation.Comment: LaTex, 22 pages, 5 EPS file
Models for Enhanced Absorption in Inhomogeneous Superconductors
We discuss the low-frequency absorption arising from quenched inhomogeneity
in the superfluid density rho_s of a model superconductor. Such inhomogeneities
may arise in a high-T_c superconductor from a wide variety of sources,
including quenched random disorder and static charge density waves such as
stripes. Using standard classical methods for treating randomly inhomogeneous
media, we show that both mechanisms produce additional absorption at finite
frequencies. For a two-fluid model with weak mean-square fluctuations <(d
rho_s)^2 > in rho_s and a frequency-independent quasiparticle conductivity, the
extra absorption has oscillator strength proportional to the quantity <(d
rho_s)^2>/rho_s, as observed in some experiments. Similar behavior is found in
a two-fluid model with anticorrelated fluctuations in the superfluid and normal
fluid densities. The extra absorption typically occurs as a Lorentzian centered
at zero frequency. We present simple model calculations for this extra
absorption under conditions of both weak and strong fluctuations. The relation
between our results and other model calculations is briefly discussed
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