IL1B-CGTC haplotype is associated with colorectal cancer in admixed individuals with increased African ancestry

Single-nucleotide polymorphisms (SNPs) in cytokine genes can affect gene expression and thereby modulate inflammation and carcinogenesis. However, the data on the association between SNPs in the interleukin 1 beta gene (IL1B) and colorectal cancer (CRC) are conflicting. We found an association between a 4-SNP haplotype block of the IL1B (-3737C/-1464G/-511T/-31C) and CRC risk, and this association was exclusively observed in individuals with a higher proportion of African ancestry, such as individuals from the Coastal Colombian region (odds ratio, OR 2.06; 95% CI 1.31–3.25; p < 0.01). Moreover, a significant interaction between this CRC risk haplotype and local African ancestry dosage was identified in locus 2q14 (p = 0.03). We conclude that Colombian individuals with high African ancestry proportions at locus 2q14 harbour more IL1B-CGTC copies and are consequently at an increased risk of CRC. This haplotype has been previously found to increase the IL1B promoter activity and is the most frequent haplotype in African Americans. Despite of limitations in the number of samples and the lack of functional analysis to examine the effect of these haplotypes on CRC cell lines, our results suggest that inflammation and ethnicity play a major role in the modulation of CRC risk

10Be exposure age constraints on the Late Weichselian ice-sheet geometry and dynamics in inter-ice-stream areas, western Svalbard

The Late Weichselian ice sheet of western Svalbard was characterized by ice streams and inter-ice-stream areas. To reconstruct its geometry and dynamics we investigated the glacial geology of two areas on the island of Prins Karls Forland and the Mitrahalvøya peninsula. Cosmogenic 10Be surface exposure dating of glacial erratics and bedrock was used to constrain past ice thickness, providing minimum estimates in both areas. Contrary to previous studies, we found that Prins Karls Forland experienced a westward ice flux from Spitsbergen. Ice thickness reached >470 m a.s.l., and warm-based conditions occurred periodically. Local deglaciation took place between 16 and 13 ka. At Mitrahalvøya, glacier ice draining the Krossfjorden basin reached >300 m a.s.l., and local deglaciation occurred at c. 13 ka. We propose the following succession of events for the last deglaciation. After the maximum glacier extent, ice streams in the cross-shelf troughs and fjords retreated, tributary ice streams formed in Forlandsundet and Krossfjorden, and, finally, local ice caps were isolated over both Prins Karls Forland and Mitrahalvøya and their adjacent shelves

Episodic Neoglacial snowline descent and glacier expansion on Svalbard reconstructed from the ¹⁴C ages of ice-entombed plants

The response of the Northern Hemisphere cryosphere to the monotonic decline in summer insolation and variable radiative forcing during the Holocene has been one of irregular expansion culminating in the Little Ice Age, when most glaciers attained their maximum late Holocene dimensions. Although periods of intervening still-stand or ice-retreat can be reconstructed by direct dating of ice-recessional features, defining times of Neoglacial ice growth has been limited to indirect proxies preserved in distal archives. Here we report 45 precise radiocarbon dates on in situ plants emerging from beneath receding glaciers on Svalbard that directly date the onset of snowline descent and glacier expansion, entombing the plants. Persistent snowline lowering occurred between 4.0 and 3.4 ka, but with little additional persistent lowering until early in the first millennium AD. Populations of individual 14C calendar age results and their aggregate calendar age probabilities define discrete episodes of vegetation kill and snowline lowering 240–340 AD, 410–540 AD and 670–750 AD, each with a lower snowline than the preceding episode, followed by additional snowline lowering between 1000 and 1220 AD, and between 1300 and 1450 AD. Snowline changes after 1450 AD, including the maximum ice extent of the Little Ice Age are not resolved by our collections, although snowlines remained lower than their 1450 AD level until the onset of modern warming. A time-distance diagram derived from a 250-m-long transect of dated ice-killed plants documents ice-margin advances ~750, ~1100 and after ~1500 AD, concordant with distributed vegetation kill ages seen in the aggregate data set, supporting our central thesis that vegetation kill ages provide direct evidence of snowline lowering and cryospheric expansion. The mid- to late-Holocene history of snowline lowering on Svalbard is similar to ELA reconstructions of Norwegian and Svalbard cirque glaciers, and consistent with a cryospheric response to the secular decline of regional summertime insolation and stepped changes in nearby surface ocean environments. The widespread exposure of entombed plants dating from the first millennium AD suggests that Svalbard's average summer temperatures of the past century now exceed those of any century since at least 700 AD, including medieval times

Frequent long-distance plant colonization in the changing Arctic

Times Cited: 2International audienceThe ability of species to track their ecological niche after climate change is a major source of uncertainty in predicting their future distribution. By analyzing DNA fingerprinting ( amplified fragment-length polymorphism) of nine plant species, we show that long-distance colonization of a remote arctic archipelago, Svalbard, has occurred repeatedly and from several source regions. Propagules are likely carried by wind and drifting sea ice. The genetic effect of restricted colonization was strongly correlated with the temperature requirements of the species, indicating that establishment limits distribution more than dispersal. Thus, it may be appropriate to assume unlimited dispersal when predicting long-term range shifts in the Arctic