Sensitivity study of dynamics variability for mild-carbon steel structures affected by corrosion

Background: Corrosion propagation mainly occurs due to environmental conditions and to the absence of adequate maintenance. The corrosion propagation affects the structural performances of slender and thin structures, in particular in the case of structure very sensitive to the wind action and its dynamical phenomena, because commonly they are designed with a precise optimization of the stiffness/mass ratio. The static and dynamic wind action represent an immediate safety hazard in the case of structural stiffness and mass reduction due to the corrosion depth. Objective: This paper discusses the dynamics behavior variability due to the corrosion depth propagation for two significant examples of slender and thin structure (i.e. tower and truss roof). Methods: The structures assumed as case of study are made of mild carbon. The corrosion depth variability was estimated based on literature references. The structural natural frequencies and modal shapes are assumed as significant magnitudes to discuss the effect of the corrosion on the structural elements. Results: Results have shown that the corrosion depth gives a significant reduction of frequencies and modification of modal shapes. Conclusion: Results have shown that the corrosion depth affect the structural behavior long before a structural collapse. It suggests that a monitoring must be done to estimate the structure reliability for the Serviceability limit state under Characteristic design loads

Robustness assessment approaches for steel framed structures under catastrophic events

The current study deals with the robustness assessment methods of steel framed buildings under catastrophic events. Two steel framed buildings, designed according to old and new seismic Italian codes, have been herein analysed, by considering the uncertainties of both the material strength and the applied loads, through two investigation methods. First, within the methodologies used for robustness assessment under seismic loads, a deterministic method, framed within the Performance Based Seismic Design (PBSD), has been applied. Later on, the robustness of studied structures under different column-removed conditions, related to different catastrophic events (blast, impact, fire and so on), has been assessed by means of two forcebased analysis techniques (a literature approach and a more advanced procedure) in order to estimate their resistance against progressive collapse. The application of the two methods has allowed to calculate the robustness index of examined structures, by taking into account the influence of both the catenary effect phenomenon and different beam-to-column joints, with the final aim to show their behavioural difference in terms of robustness

The Influence of the Aspect Ratio on the Lateral Response of the Sheathed Cold Formed Steel Walls

The influence of the aspect ratio on the lateral response of cold formed steel walls is analyzed by three design methodologies. In particular the prediction provided by the AISI Lateral Design, that is at the moment the main document for the design of CFS buildings under horizontal loads, is compared with the results obtained by applying the principles of mechanics and with those provided by non-linear finite element models. This paper presents and discusses in terms of strength and stiffness the validity of the different design methodologies in case of non-conventional wall aspect ratios comparing the numerical results with available experimental data

An optimization-based rigid block modeling approach to seismic assessment of dry-joint masonry structures subjected to settlements

A rigid block modeling approach is presented for rocking dynamics and nonlinear static analysis of dry-joint masonry structures subjected to settlements and earthquake excitations. For the different types of analysis, a unified optimization-based formulation is adopted, which is equivalent to the system governing the static and dynamic structural response. Sequential solution procedures are used for time integration and for pushover analysis which take into account the effects of large displacements under the combined action of support movements and lateral loads. No-tension elastic contacts with finite shear strength are considered at block in-terfaces for time-history analysis and to obtain the elastic branch of pushover curves in nonlinear static analysis. A unilateral rigid contact behavior is also considered to obtain the descending post-peak branch of pushover curves corresponding to the activation of the rigid-body rocking motion, according to displacement-based assessment methods of failure mechanisms adopted in the standards. Comparisons with numerical models and experimental tests on a rocking block and on a buttressed arch are presented to show the accuracy of the developed approach. Simple tests on dry-joint tuff panels on the tilting table were also carried out to show the effects of imposed movements at support on the response to lateral loads. Finally, an application is presented to a full-scale triumphal arch subjected to the combined action of support movements and earthquake excitation to discuss, on the basis of the developed model, the effects of settlement-induced damage on seismic performance. The numerical analyses showed that the lateral force, the displacement capacity and the rocking response can be significantly affected by support movements, pointing out the relevance of the current building condition in the seismic safety assessment.- The financial support of the research project DPC-ReLUIS 2022-2024: Work Package 5 "Integrated and low-impact strengthening interventions" funded by the Civil Protection Department IT (Grant no. 897-01/04/2022) is acknowledged. The authors are grateful to Prof. Chiara Calderini from the University of Genova for providing data from the experimental tests on the arch-pillars system investigated in the manuscript. The authors are also grateful to Mr. Domenico Imperatrice from the Department of Structures for Engineering and Architecture for his assistance and support throughout the experimental investigation on the wall panels subjected to support movement and lateral loads

Human cytomegalovirus-induced host protein citrullination is crucial for viral replication

Citrullination is the conversion of arginine-to-citrulline by protein arginine deiminases (PADs), whose dysregulation is implicated in the pathogenesis of various types of cancers and autoimmune diseases. Consistent with the ability of human cytomegalovirus (HCMV) to induce post-translational modifications of cellular proteins to gain a survival advantage, we show that HCMV infection of primary human fibroblasts triggers PAD-mediated citrullination of several host proteins, and that this activity promotes viral fitness. Citrullinome analysis reveals significant changes in deimination levels of both cellular and viral proteins, with interferon (IFN)-inducible protein IFIT1 being among the most heavily deiminated one. As genetic depletion of IFIT1 strongly enhances HCMV growth, and in vitro IFIT1 citrullination impairs its ability to bind to 5\u27-ppp-RNA, we propose that viral-induced IFIT1 citrullination is a mechanism of HCMV evasion from host antiviral resistance. Overall, our findings point to a crucial role of citrullination in subverting cellular responses to viral infection