125 research outputs found

    The economic development of small countries : problems, strategies and policies

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    The number of studies dealing with economic problems of small countries is growing. They have contributed to our general knowledge on the economics of these societies. Nevertheless, there is no clear evidence that a successful economic policy will be following from this knowledge. This, of course, is not unusual in matters of science. First of all, the exploration of an economic problem is one thing; the solution of problems is another thing altogether. And indeed, the economic problems of small countries, especially of the very small ones, seem so grave that one could seriously question any pretention of being able to solve these. We could emphasize the lack of development possibilities and point at the long list of impediments, at political and social structures which hamper development and which are quite difficult to change, if at all. All of these arguments could be substantiated. They have in fact been substantiated for a number of very small countries, where a virtual absence of resources or diseconomies of small scale seem to deprive their inhabitants of rather basic facilities (5, p.90]. But, for the sake of our argument, let us assume another reason why, so far, development successes in very small economies have not been realized, and let us point to the limited ability of science to propose effective measures to solve real world problems. Our argument is not a philosophical one. We, therefore, neglect the reasoning that solutions to problems almost always create new problems. Our argument is of a more theoretical nature. We simply feel that the ability of science to suggest policies is sometimes rather limited, precisely because of the limitations in our scientific way of dealing with reality. And, since some of these limitations, hampering our insights into the economic life of very small economies, seem to follow from the conception of science itself - since, so to speak, some of these limitations are self-imposed - we propose to look at the economic structures of very small economies in a different way. We have toyed with the idea to illustrate our largely theoretical exercise with a case study on Malta, but, our Institute being a very small economy itself, with limited resources, we had to confine ourselves to mere illustrations. For this and other reasons, our remarks should be seen as no more than a brief exploratory note on a large problem. Clearly, our approach does not pretend to render all other possible (scientific) approaches on formulating an economic policy obsolete or unjustified.peer-reviewe

    Homozygous whole body Cbs knockout in adult mice features minimal pathology during ageing despite severe homocysteinemia

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    Deficiencies in Cystathionine-β-synthase (CBS) lead to hyperhomocysteinemia (HHCy), which is considered a risk factor for cardiovascular, bone and neurological disease. Moreover, CBS is important for the production of cysteine, hydrogen sulfide (H2 S) and glutathione. Studying the biological role of CBS in adult mice has been severely hampered by embryological disturbances and perinatal mortality. To overcome these issues and assess the effects of whole-body CBS deficiency in adult mice, we engineered and characterized a Cre-inducible Cbs knockout model during ageing. No perinatal mortality occurred before Cbs-/- induction at 10 weeks of age. Mice were followed until 90 weeks of age and ablation of Cbs was confirmed in liver and kidney but not in brain. Severe HHCy was observed in Cbs-/- (289 ± 58 µM) but not in Cbs+/- or control mice (<10 µM). Cbs-/- showed impaired growth, facial alopecia, endothelial dysfunction in absence of increased mortality, and signs of liver or kidney damage. CBS expression in skin localized to sebaceous glands and epidermis, suggesting local effects of Cbs-/- on alopecia. Cbs-/- showed increased markers of oxidative stress and senescence but expression of other H2 S producing enzymes (CSE and 3-MST) was not affected. CBS deficiency severely impaired H2 S production capacity in liver, but not in brain or kidney. In summary, Cbs-/- mice presented a mild phenotype without mortality despite severe HHCy. The findings demonstrate that HHCy is not directly linked to development of end organ damage

    Is the water footprint an appropriate tool for forestry and forest products: The Fennoscandian case

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    The water footprint by the Water Footprint Network (WF) is an ambitious tool for measuring human appropriation and promoting sustainable use of fresh water. Using recent case studies and examples from water-abundant Fennoscandia, we consider whether it is an appropriate tool for evaluating the water use of forestry and forest-based products. We show that aggregating catchment level water consumption over a product life cycle does not consider fresh water as a renewable resource and is inconsistent with the principles of the hydrologic cycle. Currently, the WF assumes that all evapotranspiration (ET) from forests is a human appropriation of water although ET from managed forests in Fennoscandia is indistinguishable from that of unmanaged forests. We suggest that ET should not be included in the water footprint of rain-fed forestry and forest-based products. Tools for sustainable water management should always contextualize water use and water impacts with local water availability and environmental sensitivity
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